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Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients.

Jouan L, Chatel-Chaix L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Bilodeau M, Grandvaux N, Lamarre D

Institut de Recherche en Immunologie et en Cancérologie (IRIC), Université de Montréal, Québec, Canada H3T 1J4.

Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effectors' response when ectopically expressed in human hepatocytes by cleaving antiviral adaptor CARDIF. However, whether HCV mediates evasion of innate immunity in patients with chronic infection remains unclear.

J. Hepatol. 2012;56(1):70-7.

Pubmed ID: 21835140

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