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Roles for MSI2 and PROX1 in hematopoietic stem cell activity.

Hope KJ, Sauvageau G

Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, Quebec, Canada.

The MSI2 and PROX1 proteins are increasingly recognized for their critical roles in the biology of primitive hematopoietic cells and for their potential contributions to leukemic pathogenesis. Here we summarize the studies that have shed light on the hematopoietic-specific roles of MSI2 and PROX1 and give an overview of the molecular mechanisms underlying their function.

Curr. Opin. Hematol. 2011;18(4):203-7.

Pubmed ID: 21577104

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