Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers M

Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.

[Figure: see text].

Sci Adv 2021;7(44):eabi5797.

Pubmed ID: 34705497