Tissue targeting in cancer: eIF4E's tale.
Institute of Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec, Canada. firstname.lastname@example.org
The eukaryotic translation initiation factor eIF4E is elevated in many human cancers. Tissue-specific targeting of eIF4E activity in ovarian cancer cells is achieved in cell culture and in mice by fusing a peptide corresponding to the eIF4E inhibitor, the eIF4E binding protein 1 (BP1), to an agonist of the gonadotropin receptor.
Clin. Cancer Res. 2009;15(13):4254-5.
Pubmed ID: 19509132