Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.
CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, 900 rue Saint-Denis, Montréal, Qc H2X 0A9, Canada.
IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular studies have provided the rational for a key implication of IKKε in breast cancer cells proliferation and invasiveness through the phosphorylation of several substrates.
BMC Cancer 2017;17(1):356.
Pubmed ID: 28532474