Sonic Hedgehog factor Gli1: As good as resistant.

Zahreddine HA, Culjkovic-Kraljacic B, Borden KL

Institute for Research in Immunology and Cancer; University of Montreal ; Montreal, QC Canada.

Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug metabolism enzymes, specifically the UGT1A family.

Mol Cell Oncol 2015;2(1):e961827.

Pubmed ID: 27308395