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Bigger Isn't Always Better: Cell Size and the Spindle Assembly Checkpoint.

Gerhold AR, Labbé JC, Maddox PS

Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada. Electronic address:

Variation in the activity of the spindle assembly checkpoint has been observed in different cell types, yet the reason for this variability remains poorly understood. Reporting in Developmental Cell, Galli and Morgan (2016) show that checkpoint activity increases during development as cell size, and the cytoplasm-to-kinetochore ratio, decreases.

Dev. Cell 2016;36(3):244-6.

Pubmed ID: 26859348

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