β-Blockers have differential effects on the murine asthma phenotype.

Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P, Bond RA

Department of Integrative and Biology Pharmacology, University of Texas Health Science Center, Houston, TX, USA.

Our previous studies have shown the β2 -adrenoceptor and its endogenous ligand, adrenaline, are required for development of the asthma phenotype in murine asthma models. Chronic administration of some, but not other, β-blockers attenuated the asthma phenotype and led us to hypothesize that biased signalling was the basis of their differential effects, experimentally and clinically.

Br. J. Pharmacol. 2015;172(20):4833-46.

Pubmed ID: 26211486