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Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.

Der Sarkissian S, Cailhier JF, Borie M, Stevens LM, Gaboury L, Mansour S, Hamet P, Noiseux N

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada; Department of Surgery, Université de Montréal, Montreal, Quebec, Canada.

Celastrol, a triterpene from plants, has been used in traditional oriental medicine to treat various diseases. Here, we investigated the cardioprotective effects of celastrol against ischaemia.

Br. J. Pharmacol. 2014;171(23):5265-79.

Pubmed ID: 25041185

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