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Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.

Grosset AA, Labrie M, Gagné D, Vladoiu MC, Gaboury L, Doucet N, St-Pierre Y

INRS-Institut Armand-Frappier, 531 Blv, des Prairies, Laval, Quebec H7V 1B7, Canada.

Resistance to apoptosis induced by anti-cancer drugs is a major obstacle for the treatment of aggressive forms of breast cancer. Galectin-7 (gal-7) was recently shown to be specifically expressed in basal-like but not in luminal subtypes of human breast cancer.

BMC Cancer 2014;14:801.

Pubmed ID: 25367122

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