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Nucleosomal composition at the centromere: a numbers game.

Padeganeh A, De Rop V, Maddox PS

Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, H3T1J4, QC, Canada.

The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes.

Chromosome Res. 2013;21(1):27-36.

Pubmed ID: 23328870

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