Nucleosomal composition at the centromere: a numbers game.
Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, H3T1J4, QC, Canada.
The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes.
Chromosome Res. 2013;21(1):27-36.
Pubmed ID: 23328870