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Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast.

Wilhelm BT, Marguerat S, Aligianni S, Codlin S, Watt S, Bähler J

Department of Genetics, Evolution and Environment and UCL Cancer Institute, University College London, London WC1E 6BT, UK. brian.wilhelm@umontreal.ca

The generation of mature mRNAs involves interconnected processes, including transcription by RNA polymerase II (Pol II), modification of histones, and processing of pre-mRNAs through capping, intron splicing, and polyadenylation. These processes are thought to be integrated, both spatially and temporally, but it is unclear how these connections manifest at a global level with respect to chromatin patterns and transcription kinetics. We sought to clarify the relationships between chromatin, transcription and splicing using multiple genome-wide approaches in fission yeast.

Genome Biol. 2011;12(8):R82.

Pubmed ID: 21859475

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