Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.
Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada.
Injection of CD8 T cells primed against immunodominant minor histocompatibility antigens (MiHA) such as H7(a) can eradicate leukemia and solid tumors. To understand why MiHA-targeted T cells have such a potent antitumor effect it is essential to evaluate their in vivo behavior. In the present work, we therefore addressed two specific questions: what is the proliferative dynamics of H7(a)-specifc T cells in tumors, and do H7(a)-specific T cells persist long-term after adoptive transfer?
PLoS ONE 2009;4(1):e4116.
Pubmed ID: 19127288