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Kinetochore dynamics: how protein dynamics affect chromosome segregation.

Dorn JF, Maddox PS

Institute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, P.O. Box 6128, Station Centre-Ville, Montréal, QC, H3C 3J7, Canada.

Protein dynamics generate adaptive cellular architecture. This concept is exemplified by kinetochores, organelles that orchestrate chromosome segregation during mitosis. In this review, we will focus on protein dynamics at kinetochores and discuss how these dynamics impact chromosome motility during mitosis.

Curr. Opin. Cell Biol. 2012;24(1):57-63.

Pubmed ID: 22209729

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