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Structure, assembly and reading of centromeric chromatin.

Maddox PS, Corbett KD, Desai A

Institute for Research in Immunology and Cancer (IRIC), Dept of Pathology and Cell Biology, Université de Montréal, Montréal, QC H3C 3J7, Canada.

Centromeres are epigenetically defined chromatin domains marked by the presence of the histone H3 variant CENP-A. Here we review recent structural and biochemical work on CENP-A, and advances in understanding the mechanisms that propagate and read centromeric chromatin domains.

Curr. Opin. Genet. Dev. 2012;22(2):139-47.

Pubmed ID: 22178421

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