Publications

Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.



New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans.Merali S, Wang Z, Frost C, Callejo M, Hedrick M, Hui L, Meadows Shropshire S, Xu K, Bouvier M, DeSouza MM, Yang JPlatelets 2022-10-03;33(7):969-978.

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner PScience 2022-09-30;377(6614):eabn7065.

From a Cone Snail Toxin to a Competitive MC4R Antagonist.Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles NJ Med Chem 2022-09-22;65(18):12084-12094.

Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.Chana CK, Maisonneuve P, Posternak G, Grinberg NGA, Poirson J, Ona SM, Ceccarelli DF, Mader P, St-Cyr DJ, Pau V, Kurinov I, Tang X, Deng D, Cui W, Su W, Kuai L, Soll R, Tyers M, Röst HL, Batey RA, Taipale M, Gingras AC, Sicheri FJ Med Chem 2022-09-18.

Two types of human TCR differentially regulate reactivity to self and non-self antigens.Trofimov A, Brouillard P, Larouche JD, Séguin J, Laverdure JP, Brasey A, Ehx G, Roy DC, Busque L, Lachance S, Lemieux S, Perreault CiScience 2022-09-16;25(9):104968.

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development.Zhao X, Bartholdy B, Yamamoto Y, Evans EK, Alberich-Jordà M, Staber PB, Benoukraf T, Zhang P, Zhang J, Trinh BQ, Crispino JD, Hoang T, Bassal MA, Tenen DGCommun Biol 2022-09-14;5(1):961.

Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.Lisi V, Blanchard E, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VPBlood Adv 2022-09-13;6(17):5160-5164.

3D chromatin remodeling potentiates transcriptional programs driving cell invasion.Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher MProc Natl Acad Sci U S A 2022-09-06;119(36):e2203452119.

Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells.Wu Z, Bonneil E, Belford M, Boeser C, Ruiz Cuevas MV, Lemieux S, Dunyach JJ, Thibault PAnal Chem 2022-09-06;94(35):12086-12094.

Structural keys unlock RAS-MAPK cellular signalling pathway.Lavoie H, Therrien MNature 2022-09-01;609(7926):248-249.

Tieing together loose ends: telomere instability in cancer and aging.Borges G, Criqui M, Harrington LMol Oncol 2022-09-01;16(18):3380-3396.

DNA barcoded competitive clone-initiating cell analysis reveals novel features of metastatic growth in a cancer xenograft model.Aalam SMM, Tang X, Song J, Ray U, Russell SJ, Weroha SJ, Bakkum-Gamez J, Shridhar V, Sherman ME, Eaves CJ, Knapp DJHF, Kalari KR, Kannan NNAR Cancer 2022-09-01;4(3):zcac022.

Michaelis-Menten Quantification of Ligand Signaling Bias Applied to the Promiscuous Vasopressin V2 Receptor.Heydenreich FM, Plouffe B, Rizk A, Milić D, Zhou J, Breton B, Le Gouill C, Inoue A, Bouvier M, Veprintsev DBMol Pharmacol 2022-09-01;102(3):139-149.

Directing with restraint: Mechanisms of protrusion restriction in collective cell migrations.Roberto GM, Emery GSemin Cell Dev Biol 2022-09-01;129:75-81.

Silicone particles in capsules around breast implants: Establishment of a new pathological methodology to assess the number of particles around breast implants.Dziubek M, Laurent R, Bonapace-Potvin M, Gaboury L, Danino MAAnn Chir Plast Esthet 2022-08-29.

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells.Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, Durland LJ, Knapp DJHF, Zandstra PWSci Adv 2022-08-26;8(34):eabn5522.

HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.Moison C, Spinella JF, Chagraoui J, Lavallée VP, Lehnertz B, Thiollier C, Boivin I, Mayotte N, MacRae T, Marinier A, Hébert J, Sauvageau GBlood Adv 2022-08-23;6(16):4793-4806.

Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome.Kadri Y, Phan M, Bambace N, Bernard L, Cohen S, Delisle JS, Kiss T, Lachance S, Roy DC, Sauvageau G, Veilleux O, Roy J, Ahmad ICurr Oncol 2022-08-22;29(8):5955-5962.

Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers.Apavaloaei A, Hesnard L, Hardy MP, Benabdallah B, Ehx G, Thériault C, Laverdure JP, Durette C, Lanoix J, Courcelles M, Noronha N, Chauhan KD, Lemieux S, Beauséjour C, Bhatia M, Thibault P, Perreault CCell Rep 2022-08-16;40(7):111241.

Proteomic analysis of the actin cortex in interphase and mitosis.Vadnjal N, Nourreddine S, Lavoie G, Serres M, Roux PP, Paluch EKJ Cell Sci 2022-08-15;135(16).

Combined IFNγ and JAK inhibition to treat hemophagocytic lymphohistiocytosis in mice.Joly JA, Vallée A, Bourdin B, Bourbonnais S, Patey N, Gaboury L, Théorêt Y, Decaluwe HJ Allergy Clin Immunol 2022-08-13.

Afadin couples RAS GTPases to the polarity rheostat Scribble.Goudreault M, Gagné V, Jo CH, Singh S, Killoran RC, Gingras AC, Smith MJNat Commun 2022-08-05;13(1):4562.

The search for genetic dark matter and lessons learned from the journey.Borden KLBBiochem Cell Biol 2022-08-01;100(4):276-281.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.Wu Q, Nie DY, Ba-Alawi W, Ji Y, Zhang Z, Cruickshank J, Haight J, Ciamponi FE, Chen J, Duan S, Shen Y, Liu J, Marhon SA, Mehdipour P, Szewczyk MM, Dogan-Artun N, Chen W, Zhang LX, Deblois G, Prinos P, Massirer KB, Barsyte-Lovejoy D, Jin J, De Carvalho DD, Haibe-Kains B, Wang X, Cescon DW, Lupien M, Arrowsmith CHNat Chem Biol 2022-08-01;18(8):821-830.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier AJ Med Chem 2022-07-14;65(13):8843-8854.

Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid NNat Cell Biol 2022-07-01;24(7):1038-1048.

UM171 Expansion of Cord Blood Improves Donor Availability and HLA Matching For All Patients, Including Minorities.Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van't Hof W, Masson Frenet E, Sauvageau G, Cohen STransplant Cell Ther 2022-07-01;28(7):410.e1-410.e5.

Community guidelines for GPCR ligand bias: IUPHAR review 32.Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov KA, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DEBr J Pharmacol 2022-07-01;179(14):3651-3674.

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau GBlood Adv 2022-06-28;6(12):3626-3631.

Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.Leguay K, Decelle B, Elkholi IE, Bouvier M, Côté JF, Carréno SJ Cell Biol 2022-06-06;221(6)::e202109065.

The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode C. elegans.Voia A, Poupart V, Labbé JCMicroPubl Biol 2022-06-01;2022:10.17912/micropub.biology.000581.

Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.Cléroux P, Voisin L, Meloche SSLAS Discov 2022-06-01;27(4):266-271.

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, Gay J, Du D, Yang JJ, Hoff FW, Kaminski M, Tomczak K, Eric Davis R, Herranz D, Ferrando A, Jabbour EJ, Emilia Di Francesco M, Teachey DT, Horton TM, Kornblau S, Rezvani K, Sauvageau G, Gagea M, Andreeff M, Takahashi K, Marszalek JR, Lorenzi PL, Yu J, Tiziani S, Hoang T, Konopleva MNat Commun 2022-05-19;13(1):2801.

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.Hosfield DJ, Weber S, Li NS, Suavage M, Joiner CF, Hancock GR, Sullivan EA, Nduwke E, Han R, Cush S, Lainé M, Mader SC, Greene GL, Fanning SWElife 2022-05-16;11;e72512.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs.Lorzadeh A, Hammond C, Wang F, Knapp DJHF, Wong JC, Zhu JYA, Cao Q, Heravi-Moussavi A, Carles A, Wong M, Sharafian Z, Steif J, Moksa M, Bilenky M, Lavoie PM, Eaves CJ, Hirst MBMC Biol 2022-05-13;20(1):104.

Immunopeptidomics: Reading the Immune Signal That Defines Self From Nonself.Thibault P, Perreault CMol Cell Proteomics 2022-05-11;21(6):100234.

SUN2 Modulates the Propagation of HSV-1.Cruz-Palomar K, Hawkins J, Vandal C, Quenneville J, Gagnon E, Lippé RJ Virol 2022-05-11;96(9):e0045322.

The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites.Hedderich JB, Persechino M, Becker K, Heydenreich FM, Gutermuth T, Bouvier M, Bünemann M, Kolb PNat Commun 2022-05-10;13(1):2567.

Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides.Bouayad-Gervais S, St-Cyr DJ, Courcelles M, Bonneil E, Gohard FH, Thibault P, Earnshaw WC, Tyers MPept Sci (Hoboken) 2022-05-01;114(3):e24254.

YES, a novel therapeutic target in hepatocellular carcinoma.Lapouge M, Meloche SMol Cell Oncol 2022-05-01;9(1):2069993.

The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Litsios A, Goswami P, Terpstra HM, Coffin C, Vuillemenot LA, Rovetta M, Ghazal G, Guerra P, Buczak K, Schmidt A, Tollis S, Tyers M, Royer CA, Milias-Argeitis A, Heinemann MMol Biol Cell 2022-05-01;33(5):rp2.

Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.Cleyle J, Hardy MP, Minati R, Courcelles M, Durette C, Lanoix J, Laverdure JP, Vincent K, Perreault C, Thibault PMol Cell Proteomics 2022-05-01;21(5):100228.

Functional diversity in the RAS subfamily of small GTPases.Bernal Astrain G, Nikolova M, Smith MJBiochem Soc Trans 2022-04-29;50(2):921-933.

Dynamic Gate Control of Aryldiazonium Chemistry on Graphene Field-Effect Transistors.Bazán CM, Béraud A, Nguyen M, Bencherif A, Martel R, Bouilly DNano Lett 2022-04-13;22(7):2635-2642.

The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation.Gallaud E, Richard-Parpaillon L, Bataillé L, Pascal A, Métivier M, Archambault V, Giet RPLoS Genet 2022-04-01;18(4):e1010145.

ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation.Soulez M, Tanguay PL, Dô F, Dort J, Crist C, Kotlyarov A, Gaestel M, Ferron M, Dumont NA, Meloche SJ Cell Physiol 2022-04-01;237(4):2271-2287.

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wünnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JSJCI Insight 2022-03-22;7(6).

Common coupling map advances GPCR-G protein selectivity.Hauser AS, Avet C, Normand C, Mancini A, Inoue A, Bouvier M, Gloriam DEElife 2022-03-18;11:e74107.

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier MElife 2022-03-18;11:e74101.

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.Tollis S, Rizzotto A, Pham NT, Koivukoski S, Sivakumar A, Shave S, Wildenhain J, Zuleger N, Keys JT, Culley J, Zheng Y, Lammerding J, Carragher NO, Brunton VG, Latonen L, Auer M, Tyers M, Schirmer ECACS Chem Biol 2022-03-18;17(3):680-700.

CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst CEMBO Mol Med 2022-03-07:e14990.

The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.Tollis S, Singh J, Palou R, Thattikota Y, Ghazal G, Coulombe-Huntington J, Tang X, Moore S, Blake D, Bonneil E, Royer CA, Thibault P, Tyers MPLoS Biol 2022-03-01;20(3):e3001548.

Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation.Mathé J, Benhammadi M, Kobayashi KS, Brochu S, Perreault CJ Immunol 2022-03-01;208(5):1021-1033.

Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective.Veilleux O, Claveau JS, Alaoui H, Roy J, Ahmad I, Delisle JS, Kiss T, Bambace NM, Bernard L, Cohen S, Sauvageau G, Fleury I, Mollica L, Roy DC, Serroukh Y, Lachance STransplant Cell Ther 2022-03-01;28(3):145-151.

The molecular origin of the electrostatic gating of single-molecule field-effect biosensors investigated by molecular dynamics simulations.Côté S, Bouilly D, Mousseau NPhys Chem Chem Phys 2022-02-16;24(7):4174-4186.

Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus EEMBO J 2022-02-15;41(4):e106825.

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.Plouffe B, Karamitri A, Flock T, Gallion JM, Houston S, Daly CA, Bonnefond A, Guillaume JL, Le Gouill C, Froguel P, Lichtarge O, Deupi X, Jockers R, Bouvier MACS Pharmacol Transl Sci 2022-02-11;5(2):89-101.

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes.Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard E, Dieudé M, Hébert MJCell Death Dis 2022-02-11;13(2):145.

Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: a phase II study.LeBlanc R, Ahmad I, Terra R, Boudreault JS, Ogez D, Lamore K, Delisle JS, Bambace N, Bernard L, Cohen S, Kiss T, Lachance S, Landais S, Lemieux-Blanchard E, Sauvageau G, Sebag M, Roy DC, Roy JBone Marrow Transplant 2022-02-01;57(2):252-260.

Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Krosl J, Bordeleau ME, Moison C, MacRae T, Boivin I, Mayotte N, Gracias D, Baccelli I, Lavallée VP, Bisaillon R, Lehnertz B, Mendoza-Sanchez R, Ruel R, Bertomeu T, Coulombe-Huntington J, Boucher G, Noronha N, Pabst C, Tyers M, Gendron P, Lemieux S, Barabé F, Marinier A, Hébert J, Sauvageau GBlood Adv 2022-01-25;6(2):509-514.

Signaling by the tyrosine kinase Yes promotes liver cancer development.Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche SSci Signal 2022-01-18;15(717):eabj4743.

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy E, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault E, Boudreault PL, Sarret PJ Med Chem 2022-01-13;65(1):531-551.

Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.Osborne MJ, Volpon L, Memarpoor-Yazdi M, Pillay S, Thambipillai A, Czarnota S, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Cowling VH, Borden KLBJ Mol Biol 2022-01-10;434(5):167451.

Subcellular Fractionation Suitable for Studies of RNA and Protein Trafficking.Culjkovic-Kraljacic B, Borden KLBMethods Mol Biol 2022-01-01;2502:91-104.

Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.Veiga DFT, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, Lemieux S, Zúñiga-Pflücker JC, Hébert J, Cohen JP, Hoang TFront Immunol 2022-01-01;13:867443.

Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CMHypertension 2022-01-01;79(1):115-125.

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.Milan T, Celton M, Lagacé K, Roques E, Safa-Tahar-Henni S, Bresson E, Bergeron A, Hebert J, Meshinchi S, Cellot S, Barabé F, Wilhelm BTHaematologica 2022-01-01;107(1):86-99.

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