Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry.J Cell Biol 2022-06-06;221(6)::e202109065.
The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Mol Biol Cell 2022-05-01;33(5):rp2.
Functional diversity in the RAS subfamily of small GTPases.Biochem Soc Trans 2022-04-29;50(2):921-933.
SUN2 Modulates the Propagation of HSV-1.J Virol 2022-04-18:e0045322.
Dynamic Gate Control of Aryldiazonium Chemistry on Graphene Field-Effect Transistors.Nano Lett 2022-04-13;22(7):2635-2642.
Directing with restraint: Mechanisms of protrusion restriction in collective cell migrations.Semin Cell Dev Biol 2022-04-06.
The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation.PLoS Genet 2022-04-01;18(4):e1010145.
ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation.J Cell Physiol 2022-04-01;237(4):2271-2287.
Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability.Mol Cell Proteomics 2022-03-31:100228.
Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10.SLAS Discov 2022-03-25.
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.JCI Insight 2022-03-22;7(6).
Common coupling map advances GPCR-G protein selectivity.Elife 2022-03-18;11:e74107.
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.Elife 2022-03-18;11:e74101.
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.ACS Chem Biol 2022-03-18;17(3):680-700.
UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.Transplant Cell Ther 2022-03-17.
CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.Blood Adv 2022-03-14.
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.EMBO Mol Med 2022-03-07:e14990.
The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.PLoS Biol 2022-03-01;20(3):e3001548.
Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation.J Immunol 2022-03-01;208(5):1021-1033.
Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective.Transplant Cell Ther 2022-03-01;28(3):145-151.
The molecular origin of the electrostatic gating of single-molecule field-effect biosensors investigated by molecular dynamics simulations.Phys Chem Chem Phys 2022-02-16;24(7):4174-4186.
Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.EMBO J 2022-02-15;41(4):e106825.
Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes.Cell Death Dis 2022-02-11;13(2):145.
Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX.Br J Pharmacol 2022-02-01.
Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: a phase II study.Bone Marrow Transplant 2022-02-01;57(2):252-260.
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Blood Adv 2022-01-25;6(2):509-514.
Signaling by the tyrosine kinase Yes promotes liver cancer development.Sci Signal 2022-01-18;15(717):eabj4743.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.J Med Chem 2022-01-13;65(1):531-551.
Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.J Mol Biol 2022-01-10;434(5):167451.
Subcellular Fractionation Suitable for Studies of RNA and Protein Trafficking.Methods Mol Biol 2022-01-01;2502:91-104.
Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.Front Immunol 2022-01-01;13:867443.
Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time.Hypertension 2022-01-01;79(1):115-125.
Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.Haematologica 2022-01-01;107(1):86-99.
Suivez l'IRIC :