Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.Possamaï D, Hanafi LA, Bellemare-Pelletier A, Hamelin K, Thébault P, Hébert MJ, Gagnon E, Leclerc D, Lapointe RPLoS One 2021-12-31;16(12):e0261987.

HLF expression defines the human hematopoietic stem cell state.Lehnertz B, Chagraoui J, MacRae T, Tomellini E, Corneau S, Mayotte N, Boivin I, Durand A, Gracias D, Sauvageau GBlood 2021-12-23;138(25):2642-2654.

The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation.Mars JC, Ghram M, Culjkovic-Kraljacic B, Borden KLBCancers (Basel) 2021-12-08;13(24).

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs.Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu FCell Res 2021-12-01;31(12):1311-1314.

Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis.Uriarte M, Sen Nkwe N, Tremblay R, Ahmed O, Messmer C, Mashtalir N, Barbour H, Masclef L, Voide M, Viallard C, Daou S, Abdelhadi D, Ronato D, Paydar M, Darracq A, Boulay K, Desjardins-Lecavalier N, Sapieha P, Masson JY, Sergeev M, Kwok BH, Hulea L, Mallette FA, Milot E, Larrivée B, Wurtele H, Affar EBNat Commun 2021-11-30;12(1):6984.

MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets.Kovalchik KA, Ma Q, Wessling L, Saab F, D Duquette J, Kubiniok P, Hamelin DJ, Faridi P, Li C, Purcell AW, Jang A, Paramithiotis E, Tognetti M, Reiter L, Bruderer R, Lanoix J, Bonneil E, Courcelles M, Thibault P, Caron E, Sirois IMol Cell Proteomics 2021-11-17;21(1):100178.

Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review.Lang M, Lemieux S, Hébert J, Sauvageau G, Zawati MHJ Med Internet Res 2021-11-11;23(11):e26450.

Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat.Barrett RRG, Nash C, Diennet M, Cotnoir-White D, Doyle C, Mader S, Thomson AA, Gleason JLBioorg Med Chem Lett 2021-11-09;55:128441.

GPCR activation mechanisms across classes and macro/microscales.Hauser AS, Kooistra AJ, Munk C, Heydenreich FM, Veprintsev DB, Bouvier M, Babu MM, Gloriam DENat Struct Mol Biol 2021-11-01;28(11):879-888.

Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis.Porras L, Ismail H, Mader SCells 2021-10-31;10(11).

Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers MSci Adv 2021-10-29;7(44):eabi5797.

CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.Daouda T, Dumont-Lagacé M, Feghaly A, Benslimane Y, Panes R, Courcelles M, Benhammadi M, Harrington L, Thibault P, Major F, Bengio Y, Gagnon E, Lemieux S, Perreault CPLoS Comput Biol 2021-10-22;17(10):e1009482.

Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sánchez-Osuna M, Coulombe-Huntington J, Huard C, Mohammed M, Lima-Fernandes E, Thériault B, Halabelian L, Chan M, Joshi D, Drecun L, Yao Z, Pathmanathan S, Wong V, Lyakisheva A, Aboualizadeh F, Niu L, Li F, Kiyota T, Subramanian R, Joseph B, Aman A, Prakesch M, Isaac M, Mamai A, Poda G, Vedadi M, Marcellus R, Uehling D, Leighl N, Sacher A, Samaržija M, Jakopović M, Arrowsmith C, Tyers M, Tsao MS, Andrews D, Al-Awar R, Stagljar IJ Mol Biol 2021-10-16;433(23):167294.

Impact of Epithelial-Mesenchymal Transition on the Immune Landscape in Breast Cancer.Khadri FZ, Issac MSM, Gaboury LACancers (Basel) 2021-10-12;13(20).

Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, Jockers R, Bouvier MACS Pharmacol Transl Sci 2021-10-08;4(5):1614-1627.

Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro GACS Pharmacol Transl Sci 2021-10-08;4(5):1483-1498.

Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.Mathien S, Tesnière C, Meloche SPharmacol Rev 2021-10-01;73(4):263-296.

1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).Osborne MJ, Rahardjo AK, Volpon L, Borden KLBBiomol NMR Assign 2021-10-01;15(2):323-328.

Ackr3-Venus knock-in mouse lights up brain vasculature.Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BLMol Brain 2021-09-28;14(1):151.

Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression.Fukano M, Park M, Deblois GCancers (Basel) 2021-09-19;13(18).

A hydride transfer complex reprograms NAD metabolism and bypasses senescence.Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre GMol Cell 2021-09-16;81(18):3848-3865.e19.

Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).Fraszczak J, Arman KM, Lacroix M, Vadnais C, Gaboury L, Möröy TJ Immunol 2021-09-15;207(6):1599-1615.

The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis.Bauer J, Poupart V, Goupil E, Nguyen KCQ, Hall DH, Labbé JCDevelopment 2021-09-15;148(18).

The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.Ravindran S, Froy H, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Pilkington JG, Harrington L, Pemberton JM, Nussey DHMol Ecol 2021-09-12.

Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert DCommun Biol 2021-09-10;4(1):1062.

PSMB11 regulates gene expression in cortical thymic epithelial cells.Apavaloaei A, Laverdure JP, Perreault CCell Rep 2021-09-07;36(10):109546.

Beneficial autoimmunity improves cancer prognosis.Zitvogel L, Perreault C, Finn OJ, Kroemer GNat Rev Clin Oncol 2021-09-01;18(9):591-602.

Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent JChem Sci 2021-08-25;12(33):10990-11003.

Minireview: what is known about SUMOylation among NR4A family members?Dodat F, Mader S, Lévesque DJ Mol Biol 2021-08-23:167212.

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.Gavory G, Baril C, Laberge G, Bidla G, Koonpaew S, Sonea T, Sauvageau G, Therrien MPLoS Genet 2021-08-12;17(8):e1009730.

p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells.Janelle V, Neault M, Lebel ME, De Sousa DM, Boulet S, Durrieu L, Carli C, Muzac C, Lemieux S, Labrecque N, Melichar HJ, Mallette FA, Delisle JSFront Immunol 2021-08-09;12:698565.

Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission.Pará C, Bose P, Bruno L, Freemantle E, Taherzadeh M, Pan X, Han C, McPherson PS, Lacaille JC, Bonneil E, Thibault P, O'Leary C, Bigger B, Morales CR, Di Cristo G, Pshezhetsky AVJCI Insight 2021-08-09;6(15).

Identifying Plasmodium falciparum receptor activation using bioluminescence resonance energy transfer (BRET)-based biosensors in HEK293 cells.Pereira PHS, Garcia CRS, Bouvier MMethods Cell Biol 2021-08-07;166:223-233.

The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae.Bauer J, Lacroix L, Labbé JCMicroPubl Biol 2021-08-04;2021.

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SANat Commun 2021-08-03;12(1):4688.

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.García RA, Lupisella JA, Ito BR, Hsu MY, Fernando G, Carson NL, Allocco JJ, Ryan CS, Zhang R, Wang Z, Heroux M, Carrier M, St-Onge S, Bouvier M, Dudhgaonkar S, Nagar J, Bustamante-Pozo MM, Garate-Carrillo A, Chen J, Ma X, Search DJ, Dierks EA, Kick EK, Wexler RR, Gordon DA, Ostrowski J, Wurtz NR, Villarreal FJACC Basic Transl Sci 2021-08-01;6(8):676-689.

Proteomic strategies for characterizing ubiquitin-like modificationsChongyang Li, Trent G. Nelson, Alfred C. O. Vertegaal & Pierre Thibault  2021-07-29;1(53).

From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells.Barazetti JF, Jucoski TS, Carvalho TM, Veiga RN, Kohler AF, Baig J, Al Bizri H, Gradia DF, Mader S, Carvalho de Oliveira JCancers (Basel) 2021-07-22;13(15).

Integration of Segmented Ion Fractionation and Differential Ion Mobility on a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer.Pfammatter S, Wu Z, Bonneil E, Bailey DJ, Prasad S, Belford M, Rochon J, Picard P, Lacoursière J, Dunyach JJ, Thibault PAnal Chem 2021-07-20;93(28):9817-9825.

Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML.Herbrich S, Baran N, Cai T, Weng C, Aitken MJL, Post SM, Henderson J, Shi C, Richard-Carpentier G, Sauvageau G, Baggerly K, Al-Atrash G, Davis RE, Daver N, Zha D, Konopleva MJ Immunother Cancer 2021-07-01;9(7).

CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21.Possamaï D, Pagé G, Panès R, Gagnon E, Lapointe RJ Immunol 2021-07-01;207(1):77-89.

Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.Iannantuono NVG, Emery GJ Cell Sci 2021-06-15;134(12).

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.Trauelsen M, Hiron TK, Lin D, Petersen JE, Breton B, Husted AS, Hjorth SA, Inoue A, Frimurer TM, Bouvier M, O'Callaghan CA, Schwartz TWCell Rep 2021-06-15;35(11):109246.

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.Benoit MPMH, Asenjo AB, Paydar M, Dhakal S, Kwok BH, Sosa HNat Commun 2021-06-15;12(1):3637.

Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression.Larouche M, Kachaner D, Wang P, Normandin K, Garrido D, Yao C, Cormier M, Johansen KM, Johansen J, Archambault VJ Cell Biol 2021-06-07;220(6).

Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KMMol Cell 2021-06-03;81(11):2332-2348.e9.

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.Sohail M, Shkreta L, Toutant J, Rabea S, Babeu JP, Huard C, Coulombe-Huntington J, Delannoy A, Placet M, Geha S, Gendron FP, Boudreau F, Tyers M, Grierson DS, Chabot BNAR Cancer 2021-06-01;3(2):zcab019.

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.Cerezo EL, Houles T, Lié O, Sarthou MK, Audoynaud C, Lavoie G, Halladjian M, Cantaloube S, Froment C, Burlet-Schiltz O, Henry Y, Roux PP, Henras AK, Romeo YPLoS Genet 2021-06-01;17(6):e1009583.

Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.Ghugari R, Tsao S, Schmidt M, Bonneil E, Brenner C, Verreault AFEBS J 2021-06-01;288(11):3478-3506.

Bioluminescence Resonance Energy Transfer (BRET) Imaging in Living Cells: Image Acquisition and Quantification.Kobayashi H, Bouvier MMethods Mol Biol 2021-05-29;2274:305-314.

Illuminating the complexity of GPCR pathway selectivity - advances in biosensor development.Wright SC, Bouvier MCurr Opin Struct Biol 2021-05-25;69:142-149.

Chromatin dynamics and DNA replication roadblocks.Hammond-Martel I, Verreault A, Wurtele HDNA Repair (Amst) 2021-05-23;104:103140.

BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.Wright SC, Lukasheva V, Le Gouill C, Kobayashi H, Breton B, Mailhot-Larouche S, Blondel-Tepaz E, Antunes Vieira N, Costa-Neto C, Héroux M, Lambert NA, Parreiras-E-Silva LT, Bouvier MProc Natl Acad Sci U S A 2021-05-18;118(20).

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault EJ Med Chem 2021-05-13;64(9):5345-5364.

NMR Detection Methods for Profiling RAS Nucleotide Cycling.Killoran RC, Smith MJMethods Mol Biol 2021-05-12;2262:169-182.

A bacterium-derived, cancer-associated immunopeptidome.Perreault C, Thibault P, Kroemer GOncoimmunology 2021-05-03;10(1):1918373.

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CCNat Commun 2021-04-30;12(1):2482.

Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense.Chelbi-Alix MK, Thibault PFront Cell Dev Biol 2021-04-21;9:671067.

Heritable variation in telomere length predicts mortality in Soay sheep.Froy H, Underwood SL, Dorrens J, Seeker LA, Watt K, Wilbourn RV, Pilkington JG, Harrington L, Pemberton JM, Nussey DHProc Natl Acad Sci U S A 2021-04-13;118(15).

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Thériault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, Hébert J, Sauvageau G, Lemieux S, Thibault P, Perreault CImmunity 2021-04-13;54(4):737-752.e10.

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7.Meyrath M, Palmer CB, Reynders N, Vanderplasschen A, Ollert M, Bouvier M, Szpakowska M, Chevigné AACS Pharmacol Transl Sci 2021-04-09;4(2):813-823.

Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies.Kuasne H, Canto LMD, Aagaard MM, Muñoz JJM, Jamblinne C, Marchi FA, Scapulatempo-Neto C, Faria EF, Lopes A, Carréno S, Rogatto SRCells 2021-04-06;10(4).

Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real time.Leguay K, Decelle B, He YY, Pagniez A, Hogue M, Kobayashi H, Le Gouill C, Bouvier M, Carréno SJ Cell Sci 2021-04-01;134(7).

SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier CMol Cell Biol 2021-03-24;41(4).

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.Girondel C, Meloche SFront Oncol 2021-03-23;11:656004.

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński JCell Rep 2021-03-23;34(12):108862.

TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.Connolly A, Panes R, Tual M, Lafortune R, Bellemare-Pelletier A, Gagnon ESci Signal 2021-03-23;14(675).

Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Moison C, Chagraoui J, Caron MC, Gagné JP, Coulombe Y, Poirier GG, Masson JY, Sauvageau GProc Natl Acad Sci U S A 2021-03-16;118(11).

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.Grunddal KV, Diep TA, Petersen N, Tough IR, Skov LJ, Liu L, Buijink JA, Mende F, Jin C, Jepsen SL, Sørensen LME, Achiam MP, Strandby RB, Bach A, Hartmann B, Frimurer TM, Hjorth SA, Bouvier M, Cox H, Holst BMol Metab 2021-03-09:101207.

Most non-canonical proteins uniquely populate the proteome or immunopeptidome.Ruiz Cuevas MV, Hardy MP, Hollý J, Bonneil E, Durette C, Courcelles M, Lanoix J, Côté C, Staudt LM, Lemieux S, Thibault P, Perreault C, Yewdell JWCell Rep 2021-03-09;34(10):108815.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil E, Thibault P, Tyers M, Harrington LAging Cell 2021-03-04:e13331.

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon DCirc Heart Fail 2021-03-01;14(3):e007351.

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGHOncogene 2021-03-01;40(12):2243-2257.

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.Cañedo EC, Totten S, Ahn R, Savage P, MacNeil D, Hudson J, Autexier C, Deblois G, Park M, Witcher M, Ursini-Siegel JJCI Insight 2021-02-22;6(4).

Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.René P, Lanfray D, Richard D, Bouvier MJCI Insight 2021-02-22;6(4).

Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish.Tschaikner PM, Regele D, Röck R, Salvenmoser W, Meyer D, Bouvier M, Geley S, Stefan E, Aanstad PDevelopment 2021-02-17;148(4).

PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, Durand M, Thibault P, Hart K, Mangos M, Veyhl J, Chen W, Tran N, Duong BC, Aman AM, Che X, Lan X, Whitley O, Zaslaver O, Barsyte-Lovejoy D, Richards LM, Restall I, Caudy A, Röst HL, Bonday ZQ, Bernstein M, Das S, Cusimano MD, Spears J, Bader GD, Pugh TJ, Tyers M, Lupien M, Haibe-Kains B, Artee Luchman H, Weiss S, Massirer KB, Prinos P, Arrowsmith CH, Dirks PBNat Commun 2021-02-12;12(1):979.

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice.Madogwe E, Schuermann Y, Siddappa D, Bordignon V, Roux PP, Duggavathi RReproduction 2021-02-01;161(2):183-193.

CentTracker: a trainable, machine learning-based tool for large-scale analyses of C. elegans germline stem cell mitosis.Zellag RM, Zhao Y, Poupart V, Singh R, Labbé JC, Gerhold ARMol Biol Cell 2021-01-27:mbcE20110716.

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance.Béraud A, Sauvage M, Bazán CM, Tie M, Bencherif A, Bouilly DAnalyst 2021-01-21;146(2):403-428.

Survival Impact of Aggressive Treatment and PD-L1 Expression in Oligometastatic NSCLC.Gauvin C, Krishnan V, Kaci I, Tran-Thanh D, Bédard K, Albadine R, Leduc C, Gaboury L, Blais N, Tehfe M, Routy B, Florescu MCurr Oncol 2021-01-20;28(1):593-605.

Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault EJ Med Chem 2021-01-14;64(1):602-615.

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau GCell Stem Cell 2021-01-07;28(1):48-62.e6.

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche SOncogene 2021-01-01;40(2):452-464.

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, Dolma S, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers MProtein Sci 2021-01-01;30(1):187-200.

UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections.Dumont-Lagacé M, Li Q, Tanguay M, Chagraoui J, Kientega T, Cardin GB, Brasey A, Trofimov A, Carli C, Ahmad I, Bambace NM, Bernard L, Kiss TL, Roy J, Roy DC, Lemieux S, Perreault C, Rodier F, Dufresne SF, Busque L, Lachance S, Sauvageau G, Cohen S, Delisle JSTransplant Cell Ther 2021-01-01;27(1):76.e1-76.e9.

Harnessing tRNA for Processing Ability and Promoter Activity.Knapp DJHF, Fulga TAMethods Mol Biol 2021-01-01;2162:89-114.

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