Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.PLoS One 2021-12-31;16(12):e0261987.
HLF expression defines the human hematopoietic stem cell state.Blood 2021-12-23;138(25):2642-2654.
The Cap-Binding Complex CBC and the Eukaryotic Translation Factor eIF4E: Co-Conspirators in Cap-Dependent RNA Maturation and Translation.Cancers (Basel) 2021-12-08;13(24).
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs.Cell Res 2021-12-01;31(12):1311-1314.
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis.Nat Commun 2021-11-30;12(1):6984.
MhcVizPipe: A Quality Control Software for Rapid Assessment of Small- to Large-Scale Immunopeptidome Datasets.Mol Cell Proteomics 2021-11-17;21(1):100178.
Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review.J Med Internet Res 2021-11-11;23(11):e26450.
Dual-function antiandrogen/HDACi hybrids based on enzalutamide and entinostat.Bioorg Med Chem Lett 2021-11-09;55:128441.
GPCR activation mechanisms across classes and macro/microscales.Nat Struct Mol Biol 2021-11-01;28(11):879-888.
Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis.Cells 2021-10-31;10(11).
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.Sci Adv 2021-10-29;7(44):eabi5797.
CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.PLoS Comput Biol 2021-10-22;17(10):e1009482.
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol 2021-10-16;433(23):167294.
Impact of Epithelial-Mesenchymal Transition on the Immune Landscape in Breast Cancer.Cancers (Basel) 2021-10-12;13(20).
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.ACS Pharmacol Transl Sci 2021-10-08;4(5):1614-1627.
Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation.ACS Pharmacol Transl Sci 2021-10-08;4(5):1483-1498.
Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.Pharmacol Rev 2021-10-01;73(4):263-296.
1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).Biomol NMR Assign 2021-10-01;15(2):323-328.
Ackr3-Venus knock-in mouse lights up brain vasculature.Mol Brain 2021-09-28;14(1):151.
Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression.Cancers (Basel) 2021-09-19;13(18).
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.Mol Cell 2021-09-16;81(18):3848-3865.e19.
Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).J Immunol 2021-09-15;207(6):1599-1615.
The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis.Development 2021-09-15;148(18).
The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.Mol Ecol 2021-09-12.
Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer.Commun Biol 2021-09-10;4(1):1062.
PSMB11 regulates gene expression in cortical thymic epithelial cells.Cell Rep 2021-09-07;36(10):109546.
Beneficial autoimmunity improves cancer prognosis.Nat Rev Clin Oncol 2021-09-01;18(9):591-602.
Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.Chem Sci 2021-08-25;12(33):10990-11003.
Minireview: what is known about SUMOylation among NR4A family members?J Mol Biol 2021-08-23:167212.
A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.PLoS Genet 2021-08-12;17(8):e1009730.
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells.Front Immunol 2021-08-09;12:698565.
Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission.JCI Insight 2021-08-09;6(15).
Identifying Plasmodium falciparum receptor activation using bioluminescence resonance energy transfer (BRET)-based biosensors in HEK293 cells.Methods Cell Biol 2021-08-07;166:223-233.
The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae.MicroPubl Biol 2021-08-04;2021.
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.Nat Commun 2021-08-03;12(1):4688.
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.JACC Basic Transl Sci 2021-08-01;6(8):676-689.
Proteomic strategies for characterizing ubiquitin-like modifications 2021-07-29;1(53).
From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells.Cancers (Basel) 2021-07-22;13(15).
Integration of Segmented Ion Fractionation and Differential Ion Mobility on a Q-Exactive Hybrid Quadrupole Orbitrap Mass Spectrometer.Anal Chem 2021-07-20;93(28):9817-9825.
Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML.J Immunother Cancer 2021-07-01;9(7).
CD40L-Stimulated B Lymphocytes Are Polarized toward APC Functions after Exposure to IL-4 and IL-21.J Immunol 2021-07-01;207(1):77-89.
Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.J Cell Sci 2021-06-15;134(12).
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.Cell Rep 2021-06-15;35(11):109246.
Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14.Nat Commun 2021-06-15;12(1):3637.
Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression.J Cell Biol 2021-06-07;220(6).
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.Mol Cell 2021-06-03;81(11):2332-2348.e9.
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.NAR Cancer 2021-06-01;3(2):zcab019.
RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.PLoS Genet 2021-06-01;17(6):e1009583.
Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.FEBS J 2021-06-01;288(11):3478-3506.
Bioluminescence Resonance Energy Transfer (BRET) Imaging in Living Cells: Image Acquisition and Quantification.Methods Mol Biol 2021-05-29;2274:305-314.
Illuminating the complexity of GPCR pathway selectivity - advances in biosensor development.Curr Opin Struct Biol 2021-05-25;69:142-149.
Chromatin dynamics and DNA replication roadblocks.DNA Repair (Amst) 2021-05-23;104:103140.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes.Proc Natl Acad Sci U S A 2021-05-18;118(20).
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.J Med Chem 2021-05-13;64(9):5345-5364.
NMR Detection Methods for Profiling RAS Nucleotide Cycling.Methods Mol Biol 2021-05-12;2262:169-182.
A bacterium-derived, cancer-associated immunopeptidome.Oncoimmunology 2021-05-03;10(1):1918373.
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.Nat Commun 2021-04-30;12(1):2482.
Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense.Front Cell Dev Biol 2021-04-21;9:671067.
Heritable variation in telomere length predicts mortality in Soay sheep.Proc Natl Acad Sci U S A 2021-04-13;118(15).
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.Immunity 2021-04-13;54(4):737-752.e10.
Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7.ACS Pharmacol Transl Sci 2021-04-09;4(2):813-823.
Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies.Cells 2021-04-06;10(4).
Development of conformational BRET biosensors that monitor ezrin, radixin and moesin activation in real time.J Cell Sci 2021-04-01;134(7).
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.Mol Cell Biol 2021-03-24;41(4).
Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.Front Oncol 2021-03-23;11:656004.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.Cell Rep 2021-03-23;34(12):108862.
TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.Sci Signal 2021-03-23;14(675).
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Proc Natl Acad Sci U S A 2021-03-16;118(11).
Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.Mol Metab 2021-03-09:101207.
Most non-canonical proteins uniquely populate the proteome or immunopeptidome.Cell Rep 2021-03-09;34(10):108815.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Aging Cell 2021-03-04:e13331.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.Circ Heart Fail 2021-03-01;14(3):e007351.
The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Oncogene 2021-03-01;40(12):2243-2257.
p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.JCI Insight 2021-02-22;6(4).
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.JCI Insight 2021-02-22;6(4).
Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish.Development 2021-02-17;148(4).
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Nat Commun 2021-02-12;12(1):979.
Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice.Reproduction 2021-02-01;161(2):183-193.
CentTracker: a trainable, machine learning-based tool for large-scale analyses of C. elegans germline stem cell mitosis.Mol Biol Cell 2021-01-27:mbcE20110716.
Graphene field-effect transistors as bioanalytical sensors: design, operation and performance.Analyst 2021-01-21;146(2):403-428.
Survival Impact of Aggressive Treatment and PD-L1 Expression in Oligometastatic NSCLC.Curr Oncol 2021-01-20;28(1):593-605.
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.J Med Chem 2021-01-14;64(1):602-615.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell 2021-01-07;28(1):48-62.e6.
Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.Oncogene 2021-01-01;40(2):452-464.
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.Protein Sci 2021-01-01;30(1):187-200.
UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections.Transplant Cell Ther 2021-01-01;27(1):76.e1-76.e9.
Harnessing tRNA for Processing Ability and Promoter Activity.Methods Mol Biol 2021-01-01;2162:89-114.
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