Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
The Nuclear Pore Complex and mRNA Export in Cancer.Cancers (Basel) 2020-12-25;13(1).
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.Cell 2020-12-23;183(7):1813-1825.e18.
Signal Transduction Profiling of Angiotensin II Type 1 Receptor With Mutations Associated to Atrial Fibrillation in Humans.Front Pharmacol 2020-12-22;11:600132.
MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus.Blood 2020-12-10;136(24):2764-2773.
Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors.Bioorg Med Chem 2020-12-08;30:115924.
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients.Cell Death Discov 2020-12-08;6(1):141.
A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens.Front Immunol 2020-12-03;11:583287.
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.Cancer Discov 2020-12-01;10(12):1968-1987.
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis.Biochim Biophys Acta Mol Cell Res 2020-12-01;1867(12):118849.
Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors.Eur J Haematol 2020-12-01;105(6):808-811.
Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.Cell Mol Life Sci 2020-12-01;77(24):5259-5279.
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.Commun Biol 2020-11-27;3(1):719.
Proteomics of Herpes Simplex Virus Type 1 Nuclear Capsids.J Virol 2020-11-25;95(4):e01842-19.
ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species.Cell Chem Biol 2020-11-19;27(11):1452.
Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.Biochim Biophys Acta Mol Cell Res 2020-11-13;1868(2):118908.
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.ACS Med Chem Lett 2020-11-12;11(11):2261-2267.
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.bioRxiv 2020-11-06.
Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.PLoS Genet 2020-11-02;16(11):e1009184.
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.J Cell Biol 2020-11-02;219(11).
Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol 2020-11-01;16(11):1170-1178.
RAS GTPase signalling to alternative effector pathways.Biochem Soc Trans 2020-10-30;48(5):2241-2252.
The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.Proc Natl Acad Sci U S A 2020-10-27;117(43):26773-26783.
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.Sci Rep 2020-10-15;10(1):17395.
Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.Nat Prod Res 2020-10-14:1-5.
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.Sci Signal 2020-10-13;13(653).
Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study.Front Physiol 2020-10-09;11:564140.
Targeting copper metabolism to defeat KRAS-driven colorectal cancer.Mol Cell Oncol 2020-10-07;7(6):1822123.
Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age.Aging Cell 2020-10-07:e13245.
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.J. Cell Biol. 2020-10-05;219(10).
ERK signalling: a master regulator of cell behaviour, life and fate.Nat Rev Mol Cell Biol 2020-10-01;21(10):607-632.
Major multilevel molecular divergence between THP-1 cells from different biorepositories.Int. J. Cancer 2020-10-01;147(7):2000-2006.
Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only.Clin Transplant 2020-09-27:e14099.
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.Cell Rep 2020-09-22;32(12):108170.
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.EMBO J 2020-09-16:e103420.
The Origin and Immune Recognition of Tumor-Specific Antigens.Cancers (Basel) 2020-09-12;12(9).
G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase.J. Cell Biol. 2020-09-07;219(9).
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Mol Cell 2020-09-03;79(5):846-856.e8.
Agonist-induced formation of unproductive receptor-G12 complexes.Proc Natl Acad Sci U S A 2020-09-01;117(35):21723-21730.
IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells.J. Immunol. 2020-09-01;205(5):1268-1280.
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Cancer Discov 2020-09-01;10(9):1312-1329.
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.Nat Commun 2020-08-21;11(1):4205.
An ErbB2 splice variant lacking exon 16 drives lung carcinoma.Proc. Natl. Acad. Sci. U.S.A. 2020-08-18;117(33):20139-20148.
RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.RNA 2020-08-01;26(8):982-995.
BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.Development 2020-07-31;147(14).
Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-κB signaling pathway.Sci Rep 2020-07-28;10(1):12562.
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun 2020-07-24;11(1):3701.
Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.J. Biol. Chem. 2020-07-24;295(30):10153-10167.
Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells.Cells 2020-07-23;9(8).
Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma Nature Cancer 2020-07-20;1(8):840-854.
Survey Says: "COVID-19 Lockdown Hits Young Faculty and Clinical Trials".Stem Cell Reports 2020-07-14;15(1):1-5.
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.Nat Commun 2020-07-10;11(1):3464.
Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling.Anal. Chem. 2020-07-07;92(13):9194-9204.
Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors.iScience 2020-07-01;23(7):101335.
Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition.Bioinformatics 2020-07-01;36(Supplement_1):i417-i426.
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.Nat. Cell Biol. 2020-07-01;22(7):803-814.
Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice.Blood 2020-06-18;135(25):2235-2251.
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell 2020-06-11;181(6):1329-1345.e24.
The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery.RNA Biol 2020-06-04:1-13.
From transient recognition to efficient silencing: a RISCky business.Nat. Struct. Mol. Biol. 2020-06-01;27(6):519-520.
Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.Sci Rep 2020-05-29;10(1):8779.
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.Cell Rep 2020-05-19;31(7):107660.
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.Am. J. Respir. Crit. Care Med. 2020-05-15;201(10):1263-1276.
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Nat Commun 2020-05-14;11(1):2396.
Interferon, restriction factors and SUMO pathways.Cytokine Growth Factor Rev. 2020-05-08.
A targetable cue in T-cell malignancy.Blood 2020-05-07;135(19):1616-1617.
Interplay of Ubiquitin-Like Modifiers Following Arsenic Trioxide Treatment.J. Proteome Res. 2020-05-01;19(5):1999-2010.
Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.Genome Med 2020-04-28;12(1):40.
Controversies around the function of LARP1.RNA Biol 2020-04-17:1-11.
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Elife 2020-04-16;9.
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.Genetics 2020-04-15;214(4):1103-1120.
The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML.Blood 2020-04-09.
Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin.ACS Pharmacol Transl Sci 2020-04-09;2(3):148-154.
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.Leukemia 2020-04-03.
MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.J. Proteome Res. 2020-04-03;19(4):1873-1881.
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.Cancer Immunol Res 2020-04-03;8(4):544-555.
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.Hum. Mol. Genet. 2020-03-31;29(5):766-784.
Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts.Am. J. Transplant. 2020-03-20;20(3):726-738.
Cross-talk between SUMOylation and ISGylation in response to interferon.Cytokine 2020-02-17;129:155025.
Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility.Nat Commun 2020-02-14;11(1):834.
High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.Blood 2020-02-13.
Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.Front Immunol 2020-02-11;10:3118.
Editorial overview: The instability of the cancer genome: it starts at the end.Curr. Opin. Genet. Dev. 2020-02-01;60:iii-vi.
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Lancet Haematol 2020-01-31;7(2):e134-e145.
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.Dev. Cell 2020-01-29;52(2):210-222.e7.
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.Elife 2020-01-21;9.
The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy.Front Immunol 2020-01-13;10:2934.
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.JACC Basic Transl Sci 2020-01-09;4(8):905-920.
Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.Mol. Cell Proteomics 2020-01-02;19(1):50-64.
A transcriptome-based approach to identify functional modules within and across primary human immune cells.PLoS ONE 2020-01-01;15(5):e0233543.
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