Publications

Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.



PTEN reduces endosomal PtdIns(4,5)P in a phosphatase-independent manner via a PLC pathway.Mondin VE, Ben El Kadhi K, Cauvin C, Jackson-Crawford A, Bélanger E, Decelle B, Salomon R, Lowe M, Echard A, Carréno SJ. Cell Biol. 2019-07-01;218(7):2198-2214.

Agonist-induced desensitisation of β -adrenoceptors: Where, when, and how?Okeke K, Angers S, Bouvier M, Michel MCBr. J. Pharmacol. 2019-07-01;176(14):2539-2558.

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JNACS Omega 2019-06-30;4(6):10056-10069.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GYProc. Natl. Acad. Sci. U.S.A. 2019-06-25;116(26):13006-13015.

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.Killoran RC, Smith MJJ. Biol. Chem. 2019-06-21;294(25):9937-9948.

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJJ. Exp. Clin. Cancer Res. 2019-06-13;38(1):251.

Pediatric leukemia: Moving toward more accurate models.Milan T, Canaj H, Villeneuve C, Ghosh A, Barabé F, Cellot S, Wilhelm BTExp. Hematol. 2019-06-01;74:1-12.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BAPLoS ONE 2019-05-28;14(5):e0203101.

Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias.Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner PJ. Med. Chem. 2019-05-23;62(10):5111-5131.

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.Hardy MP, Audemard É, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard É, Major F, Dieudé M, Hébert MJ, Perreault CSci Rep 2019-05-10;9(1):7203.

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