Publications

Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.



MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.Issac MSM, Yousef E, Tahir MR, Gaboury LANeoplasia 2019-08-30;21(10):1015-1035.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier AJ. Med. Chem. 2019-08-22;62(16):7400-7416.

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.Dubois EL, Guitton-Sert L, Béliveau M, Parmar K, Chagraoui J, Vignard J, Pauty J, Caron MC, Coulombe Y, Buisson R, Jacquet K, Gamblin C, Gao Y, Laprise P, Lebel M, Sauvageau G, D d'Andrea A, Masson JYNucleic Acids Res. 2019-08-22;47(14):7532-7547.

Targeted variant detection using unaligned RNA-Seq reads.Audemard EO, Gendron P, Feghaly A, Lavallée VP, Hébert J, Sauvageau G, Lemieux SLife Sci Alliance 2019-08-01;2(4).

Gene Information eXtension (GIX): effortless retrieval of gene product information on any website.Knight JDR, Samavarchi-Tehrani P, Tyers M, Gingras ACNat. Methods 2019-08-01;16(8):665-666.

The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole.Arango Duque G, Jardim A, Gagnon E, Fukuda M, Descoteaux APLoS Pathog. 2019-07-29;15(7):e1007982.

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne HNeuropharmacology 2019-07-24:107718.

Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.Tomellini E, Fares I, Lehnertz B, Chagraoui J, Mayotte N, MacRae T, Bordeleau MÈ, Corneau S, Bisaillon R, Sauvageau GCell Rep 2019-07-23;28(4):1063-1073.e5.

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg JB, Barabé F, Pabst CBlood 2019-07-18;134(3):263-276.

Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.Labelle C, Marinier A, Lemieux SBioinformatics 2019-07-15;35(14):i464-i473.

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