Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.Chagraoui J, Lehnertz B, Girard S, Spinella JF, Fares I, Tomellini E, Mayotte N, Corneau S, MacRae T, Simon L, Sauvageau GPLoS ONE 2019-11-17;14(11):e0224900.

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot SBlood Adv 2019-11-12;3(21):3307-3321.

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JLGenes Chromosomes Cancer 2019-10-01;58(10):723-730.

The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge.Zeledon C, Sun X, Plutoni C, Emery GCell Rep 2019-09-17;28(12):3238-3248.e3.

Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Lymphoma Patients.Lemieux C, Ahmad I, Bambace NM, Bernard L, Cohen S, Delisle JS, Fleury I, Kiss T, Mollica L, Roy DC, Sauvageau G, Roy J, Lachance SBiol. Blood Marrow Transplant. 2019-09-12.

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro GNat Commun 2019-09-09;10(1):4075.

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carréno S, Emery GNat Commun 2019-09-02;10(1):3940.

Electrostatic interactions: From immune receptor assembly to signaling.Connolly A, Gagnon EImmunol. Rev. 2019-09-01;291(1):26-43.

Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.Roy DC, Lachance S, Cohen S, Delisle JS, Kiss T, Sauvageau G, Busque L, Ahmad I, Bernard L, Bambace N, Boumédine RS, Guertin MC, Rezvani K, Mielke S, Perreault C, Roy JBr. J. Haematol. 2019-09-01;186(5):754-766.

MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.Issac MSM, Yousef E, Tahir MR, Gaboury LANeoplasia 2019-08-30;21(10):1015-1035.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier AJ. Med. Chem. 2019-08-22;62(16):7400-7416.

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.Dubois EL, Guitton-Sert L, Béliveau M, Parmar K, Chagraoui J, Vignard J, Pauty J, Caron MC, Coulombe Y, Buisson R, Jacquet K, Gamblin C, Gao Y, Laprise P, Lebel M, Sauvageau G, D d'Andrea A, Masson JYNucleic Acids Res. 2019-08-22;47(14):7532-7547.

Targeted variant detection using unaligned RNA-Seq reads.Audemard EO, Gendron P, Feghaly A, Lavallée VP, Hébert J, Sauvageau G, Lemieux SLife Sci Alliance 2019-08-01;2(4).

Gene Information eXtension (GIX): effortless retrieval of gene product information on any website.Knight JDR, Samavarchi-Tehrani P, Tyers M, Gingras ACNat. Methods 2019-08-01;16(8):665-666.

The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole.Arango Duque G, Jardim A, Gagnon E, Fukuda M, Descoteaux APLoS Pathog. 2019-07-29;15(7):e1007982.

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.Pedersen MF, Wróbel TM, Märcher-Rørsted E, Pedersen DS, Møller TC, Gabriele F, Pedersen H, Matosiuk D, Foster SR, Bouvier M, Bräuner-Osborne HNeuropharmacology 2019-07-24:107718.

Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.Tomellini E, Fares I, Lehnertz B, Chagraoui J, Mayotte N, MacRae T, Bordeleau MÈ, Corneau S, Bisaillon R, Sauvageau GCell Rep 2019-07-23;28(4):1063-1073.e5.

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg JB, Barabé F, Pabst CBlood 2019-07-18;134(3):263-276.

Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.Labelle C, Marinier A, Lemieux SBioinformatics 2019-07-15;35(14):i464-i473.

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau GCancer Cell 2019-07-08;36(1):84-99.e8.

PTEN reduces endosomal PtdIns(4,5)P in a phosphatase-independent manner via a PLC pathway.Mondin VE, Ben El Kadhi K, Cauvin C, Jackson-Crawford A, Bélanger E, Decelle B, Salomon R, Lowe M, Echard A, Carréno SJ. Cell Biol. 2019-07-01;218(7):2198-2214.

Agonist-induced desensitisation of β -adrenoceptors: Where, when, and how?Okeke K, Angers S, Bouvier M, Michel MCBr. J. Pharmacol. 2019-07-01;176(14):2539-2558.

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JNACS Omega 2019-06-30;4(6):10056-10069.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GYProc. Natl. Acad. Sci. U.S.A. 2019-06-25;116(26):13006-13015.

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.Killoran RC, Smith MJJ. Biol. Chem. 2019-06-21;294(25):9937-9948.

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.Da Costa EM, Armaos G, McInnes G, Beaudry A, Moquin-Beaudry G, Bertrand-Lehouillier V, Caron M, Richer C, St-Onge P, Johnson JR, Krogan N, Sai Y, Downey M, Rafei M, Boileau M, Eppert K, Flores-Díaz E, Haman A, Hoang T, Sinnett D, Beauséjour C, McGraw S, Raynal NJJ. Exp. Clin. Cancer Res. 2019-06-13;38(1):251.

Pediatric leukemia: Moving toward more accurate models.Milan T, Canaj H, Villeneuve C, Ghosh A, Barabé F, Cellot S, Wilhelm BTExp. Hematol. 2019-06-01;74:1-12.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BAPLoS ONE 2019-05-28;14(5):e0203101.

Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias.Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner PJ. Med. Chem. 2019-05-23;62(10):5111-5131.

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.Hardy MP, Audemard É, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard É, Major F, Dieudé M, Hébert MJ, Perreault CSci Rep 2019-05-10;9(1):7203.

Accurate Quantitative Proteomic Analyses Using Metabolic Labeling and High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS).Pfammatter S, Bonneil E, McManus FP, Thibault PJ. Proteome Res. 2019-05-03;18(5):2129-2138.

Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.Bell S, Rousseau J, Peng H, Aouabed Z, Priam P, Theroux JF, Jefri M, Tanti A, Wu H, Kolobova I, Silviera H, Manzano-Vargas K, Ehresmann S, Hamdan FF, Hettige N, Zhang X, Antonyan L, Nassif C, Ghaloul-Gonzalez L, Sebastian J, Vockley J, Begtrup AG, Wentzensen IM, Crunk A, Nicholls RD, Herman KC, Deignan JL, Al-Hertani W, Efthymiou S, Salpietro V, Miyake N, Makita Y, Matsumoto N, Østern R, Houge G, Hafström M, Fassi E, Houlden H, Klein Wassink-Ruiter JS, Nelson D, Goldstein A, Dabir T, van Gils J, Bourgeron T, Delorme R, Cooper GM, Martinez JE, Finnila CR, Carmant L, Lortie A, Oegema R, van Gassen K, Mehta SG, Huhle D, Abou Jamra R, Martin S, Brunner HG, Lindhout D, Au M, Graham JM, Coubes C, Turecki G, Gravel S, Mechawar N, Rossignol E, Michaud JL, Lessard J, Ernst C, Campeau PMAm. J. Hum. Genet. 2019-05-02;104(5):815-834.

Chemogenetics defines receptor-mediated functions of short chain free fatty acids.Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan GNat. Chem. Biol. 2019-05-01;15(5):489-498.

Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.Davis MR, Delaleau M, Borden KLBCell Rep 2019-04-30;27(5):1397-1408.e4.

Discovery and characterization of actionable tumor antigens.Ehx G, Perreault CGenome Med 2019-04-30;11(1):29.

Rapid detection of Bacillus ionophore cereulide in food products.Ducrest PJ, Pfammatter S, Stephan D, Vogel G, Thibault P, Schnyder BSci Rep 2019-04-09;9(1):5814.

Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine.Ghanbari F, Hebert-Losier A, Barry J, Poirier D, Giguere V, Mader S, Philip AJ. Steroid Biochem. Mol. Biol. 2019-04-05;191:105352.

Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.Cyr P, Flynn-Robitaille J, Boissarie P, Marinier AOrg. Lett. 2019-04-05;21(7):2265-2268.

Identification of Allosteric Inhibitors against Active Caspase-6.Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc ACSci Rep 2019-04-02;9(1):5504.

Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells.Kobayashi H, Picard LP, Schönegge AM, Bouvier MNat Protoc 2019-04-01;14(4):1084-1107.

Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer.Dong S, Lau V, Song R, Ierullo M, Esteban E, Wu Y, Sivieng T, Nahal H, Gaudinier A, Pasha A, Oughtred R, Dolinski K, Tyers M, Brady SM, Grene R, Usadel B, Provart NJPlant Physiol. 2019-04-01;179(4):1893-1907.

Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease.Lemieux C, Ahmad I, Bambace NM, Bernard L, Cohen S, Delisle JS, Fleury I, Kiss T, Mollica L, Roy DC, Sauvageau G, Roy J, Lachance SLeuk. Res. 2019-04-01;79:75-80.

Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y.Coutinho de Oliveira L, Volpon L, Osborne MJ, Borden KLBBiomol NMR Assign 2019-04-01;13(1):9-13.

The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans.Sellam A, Chaillot J, Mallick J, Tebbji F, Richard Albert J, Cook MA, Tyers MPLoS Genet. 2019-03-28;15(3):e1008052.

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BLiScience 2019-03-15;14:47-57.

GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs.Zahreddine HA, Culjkovic-Kraljacic B, Gasiorek J, Duchaine J, Borden KLBACS Chem. Biol. 2019-03-15;14(3):348-355.

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche SMol. Cell. Biol. 2019-03-15;39(6).

CDK9 and mTOR: trading places.Borden KLBBlood 2019-03-14;133(11):1167-1168.

IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis.Carim SC, Ben El Kadhi K, Yan G, Sweeney ST, Hickson GR, Carréno S, Lowe MCurr. Biol. 2019-03-04;29(5):775-789.e7.

Drug combinations: a strategy to extend the life of antibiotics in the 21st century.Tyers M, Wright GDNat. Rev. Microbiol. 2019-03-01;17(3):141-155.

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault PMol. Cell Proteomics 2019-03-01;18(3):408-422.

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CAOncogene 2019-03-01;38(13):2241-2262.

Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Gregory-Evans CY, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah AHum. Mol. Genet. 2019-03-01;28(5):778-795.

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau GBlood Adv 2019-02-26;3(4):552-563.

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SOProc. Natl. Acad. Sci. U.S.A. 2019-02-19;116(8):2967-2976.

Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader SOncogene 2019-02-01;38(7):1019-1037.

Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes.Osborne MJ, Coutinho de Oliveira L, Volpon L, Zahreddine HA, Borden KLBJ. Mol. Biol. 2019-01-18;431(2):258-272.

The BioGRID interaction database: 2019 update.Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers MNucleic Acids Res. 2019-01-08;47(D1):D529-D541.

Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E.Volpon L, Osborne MJ, Borden KLBCurr. Protein Pept. Sci. 2019-01-01;20(6):525-535.

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