Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation.Proc. Natl. Acad. Sci. U.S.A. 2019-12-24;116(51):25839-25849.
Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.Elife 2019-12-23;8.
Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia.Cancers (Basel) 2019-12-21;11(12).
Genetic characterization of ABT-199 sensitivity in human AML.Leukemia 2019-12-19;34(1):63-74.
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1.Sci Rep 2019-12-09;9(1):17620.
Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.Proc. Natl. Acad. Sci. U.S.A. 2019-12-07;116(48):24056-24065.
Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia.Genes Chromosomes Cancer 2019-12-03;59(2):125-130.
Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting.Appl Health Econ Health Policy 2019-12-02;17(6):827-839.
The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia.Leukemia 2019-11-29;33(12):2830-2841.
Axillary Lymph Node Ultrasound Following Neoadjuvant Chemotherapy in Biopsy-Proven Node-Positive Breast Cancer: Results from the SN FNAC Study.Ann. Surg. Oncol. 2019-11-20;26(13):4337-4345.
UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.PLoS ONE 2019-11-17;14(11):e0224900.
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.Blood Adv 2019-11-12;3(21):3307-3321.
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.Genes Chromosomes Cancer 2019-10-01;58(10):723-730.
The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge.Cell Rep 2019-09-17;28(12):3238-3248.e3.
Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Lymphoma Patients.Biol. Blood Marrow Transplant. 2019-09-12.
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.Nat Commun 2019-09-09;10(1):4075.
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.Nat Commun 2019-09-02;10(1):3940.
Electrostatic interactions: From immune receptor assembly to signaling.Immunol. Rev. 2019-09-01;291(1):26-43.
Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.Br. J. Haematol. 2019-09-01;186(5):754-766.
MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.Neoplasia 2019-08-30;21(10):1015-1035.
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.J. Med. Chem. 2019-08-22;62(16):7400-7416.
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.Nucleic Acids Res. 2019-08-22;47(14):7532-7547.
Targeted variant detection using unaligned RNA-Seq reads.Life Sci Alliance 2019-08-01;2(4).
Gene Information eXtension (GIX): effortless retrieval of gene product information on any website.Nat. Methods 2019-08-01;16(8):665-666.
The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole.PLoS Pathog. 2019-07-29;15(7):e1007982.
Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.Neuropharmacology 2019-07-24:107718.
Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.Cell Rep 2019-07-23;28(4):1063-1073.e5.
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.Blood 2019-07-18;134(3):263-276.
Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.Bioinformatics 2019-07-15;35(14):i464-i473.
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.Cancer Cell 2019-07-08;36(1):84-99.e8.
PTEN reduces endosomal PtdIns(4,5)P in a phosphatase-independent manner via a PLC pathway.J. Cell Biol. 2019-07-01;218(7):2198-2214.
Agonist-induced desensitisation of β -adrenoceptors: Where, when, and how?Br. J. Pharmacol. 2019-07-01;176(14):2539-2558.
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.ACS Omega 2019-06-30;4(6):10056-10069.
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.Proc. Natl. Acad. Sci. U.S.A. 2019-06-25;116(26):13006-13015.
Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.J. Biol. Chem. 2019-06-21;294(25):9937-9948.
Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.J. Exp. Clin. Cancer Res. 2019-06-13;38(1):251.
Pediatric leukemia: Moving toward more accurate models.Exp. Hematol. 2019-06-01;74:1-12.
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.PLoS ONE 2019-05-28;14(5):e0203101.
Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias.J. Med. Chem. 2019-05-23;62(10):5111-5131.
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.Sci Rep 2019-05-10;9(1):7203.
Accurate Quantitative Proteomic Analyses Using Metabolic Labeling and High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS).J. Proteome Res. 2019-05-03;18(5):2129-2138.
Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.Am. J. Hum. Genet. 2019-05-02;104(5):815-834.
Chemogenetics defines receptor-mediated functions of short chain free fatty acids.Nat. Chem. Biol. 2019-05-01;15(5):489-498.
Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.Cell Rep 2019-04-30;27(5):1397-1408.e4.
Discovery and characterization of actionable tumor antigens.Genome Med 2019-04-30;11(1):29.
Rapid detection of Bacillus ionophore cereulide in food products.Sci Rep 2019-04-09;9(1):5814.
Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine.J. Steroid Biochem. Mol. Biol. 2019-04-05;191:105352.
Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.Org. Lett. 2019-04-05;21(7):2265-2268.
Identification of Allosteric Inhibitors against Active Caspase-6.Sci Rep 2019-04-02;9(1):5504.
Bioluminescence resonance energy transfer-based imaging of protein-protein interactions in living cells.Nat Protoc 2019-04-01;14(4):1084-1107.
Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer.Plant Physiol. 2019-04-01;179(4):1893-1907.
Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease.Leuk. Res. 2019-04-01;79:75-80.
Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y.Biomol NMR Assign 2019-04-01;13(1):9-13.
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans.PLoS Genet. 2019-03-28;15(3):e1008052.
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.iScience 2019-03-15;14:47-57.
GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs.ACS Chem. Biol. 2019-03-15;14(3):348-355.
Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.Mol. Cell. Biol. 2019-03-15;39(6).
CDK9 and mTOR: trading places.Blood 2019-03-14;133(11):1167-1168.
IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis.Curr. Biol. 2019-03-04;29(5):775-789.e7.
Drug combinations: a strategy to extend the life of antibiotics in the 21st century.Nat. Rev. Microbiol. 2019-03-01;17(3):141-155.
Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.Mol. Cell Proteomics 2019-03-01;18(3):408-422.
Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia.Oncogene 2019-03-01;38(13):2241-2262.
Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.Hum. Mol. Genet. 2019-03-01;28(5):778-795.
Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.Blood Adv 2019-02-26;3(4):552-563.
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.Proc. Natl. Acad. Sci. U.S.A. 2019-02-19;116(8):2967-2976.
Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.Oncogene 2019-02-01;38(7):1019-1037.
Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes.J. Mol. Biol. 2019-01-18;431(2):258-272.
The BioGRID interaction database: 2019 update.Nucleic Acids Res. 2019-01-08;47(D1):D529-D541.
Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E.Curr. Protein Pept. Sci. 2019-01-01;20(6):525-535.
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