Publications

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PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.Apavaloaei A, Brochu S, Dong M, Rouette A, Hardy MP, Villafano G, Murata S, Melichar HJ, Perreault CJ. Immunol. 2018-12-19.

Noncoding regions are the main source of targetable tumor-specific antigens.Laumont CM, Vincent K, Hesnard L, Audemard É, Bonneil É, Laverdure JP, Gendron P, Courcelles M, Hardy MP, Côté C, Durette C, St-Pierre C, Benhammadi M, Lanoix J, Vobecky S, Haddad E, Lemieux S, Thibault P, Perreault CSci Transl Med 2018-12-05;10(470).

FZD₅ is a Gα_q-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann CSci Signal 2018-12-04;11(559).

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SASci Signal 2018-12-04;11(559).

PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault VJ. Cell Biol. 2018-12-03;217(12):4106-4123.

Detecting short RNA sequences of pathogens.Bouilly DNat Nanotechnol 2018-12-01;13(12):1094-1096.

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.Yao C, Wang C, Li Y, Zavortink M, Archambault V, Girton J, Johansen KM, Johansen JPLoS ONE 2018-11-28;13(11):e0208022.

Expression pattern of endogenous PAR-4A & C after CRISPR/Cas9-mediated genome editing.Roy V, Gagné O, Hamiche K, Labbé JC, Narbonne PMicroPubl Biol 2018-11-13;2018.

The Impact of Post-transcriptional Control: Better Living Through RNA Regulons.Culjkovic-Kraljacic B, Borden KLBFront Genet 2018-11-05;9:512.

Structural insights into binding specificity, efficacy and bias of a β₂AR partial agonist.Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BKNat. Chem. Biol. 2018-11-01;14(11):1059-1066.

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.Hamoud N, Tran V, Aimi T, Kakegawa W, Lahaie S, Thibault MP, Pelletier A, Wong GW, Kim IS, Kania A, Yuzaki M, Bouvier M, Côté JFNat Commun 2018-10-26;9(1):4470.

Translating biased signaling in the ghrelin receptor system into differential in vivo functions.Mende F, Hundahl C, Plouffe B, Skov LJ, Sivertsen B, Madsen AN, Lückmann M, Diep TA, Offermanns S, Frimurer TM, Bouvier M, Holst BProc. Natl. Acad. Sci. U.S.A. 2018-10-23;115(43):E10255-E10264.

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EBNat Commun 2018-10-22;9(1):4385.

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer TPLoS ONE 2018-10-19;13(10):e0205585.

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick FAm. J. Med. Genet. A 2018-10-10:e40632.

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté JProc. Natl. Acad. Sci. U.S.A. 2018-10-02;115(40):10028-10033.

A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.Pfammatter S, Bonneil E, McManus FP, Prasad S, Bailey DJ, Belford M, Dunyach JJ, Thibault PMol. Cell Proteomics 2018-10-01;17(10):2051-2067.

Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A).Osborne MJ, Coutinho de Oliveira L, Volpon L, Borden KLBBiomol NMR Assign 2018-10-01;12(2):315-318.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJSci Signal 2018-09-25;11(549).

The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides.Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major FNucleic Acids Res. 2018-09-19;46(16):8181-8196.

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.Ngeow KC, Friedrichsen HJ, Li L, Zeng Z, Andrews S, Volpon L, Brunsdon H, Berridge G, Picaud S, Fischer R, Lisle R, Knapp S, Filippakopoulos P, Knowles H, Steingrímsson E, Borden KLB, Patton EE, Goding CRProc. Natl. Acad. Sci. U.S.A. 2018-09-11;115(37):E8668-E8677.

Combined Enrichment/Enzymatic Approach To Study Tightly Clustered Multisite Phosphorylation on Ser-Rich Domains.Kanshin E, Pascariu M, Tyers M, D'Amours D, Thibault PJ. Proteome Res. 2018-09-07;17(9):3050-3060.

Meet the Editors: Pierre Thibault.Thibault PRapid Commun. Mass Spectrom. 2018-08-30;32(16):1320-1321.

Type 2 diabetes-associated variants of the MT₂ melatonin receptor affect distinct modes of signaling.Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume JL, Hegron A, Boissel M, Canouil M, Langenberg C, Wareham NJ, Le Gouill C, Lukasheva V, Lichtarge O, Froguel P, Bouvier M, Jockers RSci Signal 2018-08-28;11(545).

Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.Palermo AF, Diennet M, El Ezzy M, Williams BM, Cotnoir-White D, Mader S, Gleason JLBioorg. Med. Chem. 2018-08-15;26(15):4428-4440.

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.Koszela J, Pham NT, Evans D, Mann S, Perez-Pi I, Shave S, Ceccarelli DFJ, Sicheri F, Tyers M, Auer MBMC Biol. 2018-08-10;16(1):88.

Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.Picard LP, Schönegge AM, Lohse MJ, Bouvier MCommun Biol 2018-08-07;1:106.

A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key.Pintard L, Archambault VOpen Biol 2018-08-01;8(8).

Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.El-Khoury V, Béland M, Schritz A, Kim SY, Nazarov PV, Gaboury L, Sertamo K, Bernardin F, Batutu R, Antunes L, Bennett CW, Faÿs F, Berchem G, Kim YJBr. J. Cancer 2018-08-01;119(5):580-590.

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.Marquis M, Beaubois C, Lavallée VP, Abrahamowicz M, Danieli C, Lemieux S, Ahmad I, Wei A, Ting SB, Fleming S, Schwarer A, Grimwade D, Grey W, Hills RK, Vyas P, Russell N, Sauvageau G, Hébert JBlood Cancer J 2018-07-19;8(8):68.

A TFEB nuclear export signal integrates amino acid supply and glucose availability.Li L, Friedrichsen HJ, Andrews S, Picaud S, Volpon L, Ngeow K, Berridge G, Fischer R, Borden KLB, Filippakopoulos P, Goding CRNat Commun 2018-07-11;9(1):2685.

Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.Trofimova D, Paydar M, Zara A, Talje L, Kwok BH, Allingham JSNat Commun 2018-07-06;9(1):2628.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RKMol Ther Methods Clin Dev 2018-07-05;10:156-164.

Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways.Young M, Dahoun T, Sokrat B, Arber C, Chen KM, Bouvier M, Barth PProc. Natl. Acad. Sci. U.S.A. 2018-07-03;115(27):7051-7056.

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.Chaturvedi M, Schilling J, Beautrait A, Bouvier M, Benovic JL, Shukla AKTrends Biochem. Sci. 2018-07-01;43(7):533-546.

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger ALCancer Discov 2018-07-01;8(7):866-883.

Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.Palou R, Dhanaraman T, Marrakchi R, Pascariu M, Tyers M, D'Amours DPLoS Biol. 2018-06-27;16(6):e2003980.

Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Gerhold AR, Poupart V, Labbé JC, Maddox PSMol. Biol. Cell 2018-06-15;29(12):1435-1448.

Signaling Pathways Involved in the Regulation of mRNA Translation.Roux PP, Topisirovic IMol. Cell. Biol. 2018-06-15;38(12).

Gas-Phase Enrichment of Multiply Charged Peptide Ions by Differential Ion Mobility Extend the Comprehensiveness of SUMO Proteome Analyses.Pfammatter S, Bonneil E, McManus FP, Thibault PJ. Am. Soc. Mass Spectrom. 2018-06-01;29(6):1111-1124.

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau GLeukemia 2018-06-01;32(6):1349-1357.

Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation.Maroui MA, Maarifi G, McManus FP, Lamoliatte F, Thibault P, Chelbi-Alix MKMol. Cell Proteomics 2018-06-01;17(6):1196-1208.

Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.Lanoix J, Durette C, Courcelles M, Cossette É, Comtois-Marotte S, Hardy MP, Côté C, Perreault C, Thibault PProteomics 2018-06-01;18(12):e1700251.

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot SGenes Chromosomes Cancer 2018-06-01;57(6):311-319.

G1/S Transcription Factor Copy Number Is a Growth-Dependent Determinant of Cell Cycle Commitment in Yeast.Dorsey S, Tollis S, Cheng J, Black L, Notley S, Tyers M, Royer CACell Syst 2018-05-23;6(5):539-554.e11.

At Long Last, a C-Terminal Bookend for the Ubiquitin Code.Chatr-Aryamontri A, van der Sloot A, Tyers MMol. Cell 2018-05-17;70(4):568-571.

Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.McManus FP, Bourdeau V, Acevedo M, Lopes-Paciencia S, Mignacca L, Lamoliatte F, Rojas Pino JW, Ferbeyre G, Thibault PSci Rep 2018-05-17;8(1):7754.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JFCell Rep 2018-05-01;23(5):1476-1490.

Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.Chennupati V, Veiga DF, Maslowski KM, Andina N, Tardivel A, Yu EC, Stilinovic M, Simillion C, Duchosal MA, Quadroni M, Roberts I, Sankaran VG, MacDonald HR, Fasel N, Angelillo-Scherrer A, Schneider P, Hoang T, Allam RJ. Clin. Invest. 2018-04-02;128(4):1597-1614.

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia.Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O'Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivtsov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis ACancer Discov 2018-04-01;8(4):478-497.

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BLBrain Struct Funct 2018-04-01;223(3):1275-1296.

Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect.Cotnoir-White D, El Ezzy M, Boulay PL, Rozendaal M, Bouvier M, Gagnon E, Mader SProc. Natl. Acad. Sci. U.S.A. 2018-03-13;115(11):E2653-E2662.

Understanding diversity in telomere dynamics.Monaghan P, Eisenberg DTA, Harrington L, Nussey DPhilos. Trans. R. Soc. Lond., B, Biol. Sci. 2018-03-05;373(1741).

In medio stat virtus : unanticipated consequences of telomere dysequilibrium.Harrington L, Pucci FPhilos. Trans. R. Soc. Lond., B, Biol. Sci. 2018-03-05;373(1741).

[Delivery in hypoxic tumor regions of a chemotherapeutic agent encapsulated in nanoliposomes carried by magnetoaerotactic bacteria].Felfoul O, Mohammadi M, Taherkhani S, Lanauze D, Zhong Xu Y, Lafleur M, Gaboury L, Tabrizian M, Vuong T, Batist G, Beauchemin N, Radzioch D, Martel SMed Sci (Paris) 2018-03-01;34(3):197-199.

MEK drives BRAF activation through allosteric control of KSR proteins.Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien MNature 2018-02-22;554(7693):549-553.

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.Ouadda ABD, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane NOncotarget 2018-02-20;9(14):11646-11664.

Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin.Thattikota Y, Tollis S, Palou R, Vinet J, Tyers M, D'Amours DMol. Cell 2018-02-15;69(4):664-676.e5.

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PPCancer Res. 2018-02-15.

Ménière's Disease Pathophysiology: Endolymphatic Sac Immunohistochemical Study of Aquaporin-2, V2R Vasopressin Receptor, NKCC2, and TRPV4.Asmar MH, Gaboury L, Saliba IOtolaryngol Head Neck Surg 2018-02-01:194599818756829.

Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy.Laumont CM, Perreault CCell. Mol. Life Sci. 2018-02-01;75(4):607-621.

The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation.Duhamel S, Goyette MA, Thibault MP, Filion D, Gaboury L, Côté JFCell Rep 2018-01-23;22(4):1016-1030.

The SysteMHC Atlas project.Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron ENucleic Acids Res. 2018-01-04;46(D1):D1237-D1247.

Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase.Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman-Kay JDStructure 2018-01-02;26(1):28-39.e2.

Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion.El Kasmi I, Khadivjam B, Lackman M, Duron J, Bonneil E, Thibault P, Lippé RJ. Virol. 2018-01-01;92(1).

A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome.Bertomeu T, Coulombe-Huntington J, Chatr-Aryamontri A, Bourdages KG, Coyaud E, Raught B, Xia Y, Tyers MMol. Cell. Biol. 2018-01-01;38(1).