Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.J. Immunol. 2018-12-19.
Noncoding regions are the main source of targetable tumor-specific antigens.Sci Transl Med 2018-12-05;10(470).
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.Sci Signal 2018-12-04;11(559).
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.Sci Signal 2018-12-04;11(559).
PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.J. Cell Biol. 2018-12-03;217(12):4106-4123.
Detecting short RNA sequences of pathogens.Nat Nanotechnol 2018-12-01;13(12):1094-1096.
Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.PLoS ONE 2018-11-28;13(11):e0208022.
Expression pattern of endogenous PAR-4A & C after CRISPR/Cas9-mediated genome editing.MicroPubl Biol 2018-11-13;2018.
The Impact of Post-transcriptional Control: Better Living Through RNA Regulons.Front Genet 2018-11-05;9:512.
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.Nat. Chem. Biol. 2018-11-01;14(11):1059-1066.
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.Nat Commun 2018-10-26;9(1):4470.
Translating biased signaling in the ghrelin receptor system into differential in vivo functions.Proc. Natl. Acad. Sci. U.S.A. 2018-10-23;115(43):E10255-E10264.
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.Nat Commun 2018-10-22;9(1):4385.
A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.PLoS ONE 2018-10-19;13(10):e0205585.
Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.Am. J. Med. Genet. A 2018-10-10:e40632.
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.Proc. Natl. Acad. Sci. U.S.A. 2018-10-02;115(40):10028-10033.
A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.Mol. Cell Proteomics 2018-10-01;17(10):2051-2067.
Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A).Biomol NMR Assign 2018-10-01;12(2):315-318.
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.Sci Signal 2018-09-25;11(549).
The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides.Nucleic Acids Res. 2018-09-19;46(16):8181-8196.
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.Proc. Natl. Acad. Sci. U.S.A. 2018-09-11;115(37):E8668-E8677.
Combined Enrichment/Enzymatic Approach To Study Tightly Clustered Multisite Phosphorylation on Ser-Rich Domains.J. Proteome Res. 2018-09-07;17(9):3050-3060.
Meet the Editors: Pierre Thibault.Rapid Commun. Mass Spectrom. 2018-08-30;32(16):1320-1321.
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling.Sci Signal 2018-08-28;11(545).
Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.Bioorg. Med. Chem. 2018-08-15;26(15):4428-4440.
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.BMC Biol. 2018-08-10;16(1):88.
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes.Commun Biol 2018-08-07;1:106.
A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key.Open Biol 2018-08-01;8(8).
Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.Br. J. Cancer 2018-08-01;119(5):580-590.
High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia.Blood Cancer J 2018-07-19;8(8):68.
A TFEB nuclear export signal integrates amino acid supply and glucose availability.Nat Commun 2018-07-11;9(1):2685.
Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.Nat Commun 2018-07-06;9(1):2628.
UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.Mol Ther Methods Clin Dev 2018-07-05;10:156-164.
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways.Proc. Natl. Acad. Sci. U.S.A. 2018-07-03;115(27):7051-7056.
Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.Trends Biochem. Sci. 2018-07-01;43(7):533-546.
PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.Cancer Discov 2018-07-01;8(7):866-883.
Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.PLoS Biol. 2018-06-27;16(6):e2003980.
Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Mol. Biol. Cell 2018-06-15;29(12):1435-1448.
Signaling Pathways Involved in the Regulation of mRNA Translation.Mol. Cell. Biol. 2018-06-15;38(12).
Gas-Phase Enrichment of Multiply Charged Peptide Ions by Differential Ion Mobility Extend the Comprehensiveness of SUMO Proteome Analyses.J. Am. Soc. Mass Spectrom. 2018-06-01;29(6):1111-1124.
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.Leukemia 2018-06-01;32(6):1349-1357.
Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation.Mol. Cell Proteomics 2018-06-01;17(6):1196-1208.
Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods.Proteomics 2018-06-01;18(12):e1700251.
NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.Genes Chromosomes Cancer 2018-06-01;57(6):311-319.
G1/S Transcription Factor Copy Number Is a Growth-Dependent Determinant of Cell Cycle Commitment in Yeast.Cell Syst 2018-05-23;6(5):539-554.e11.
At Long Last, a C-Terminal Bookend for the Ubiquitin Code.Mol. Cell 2018-05-17;70(4):568-571.
Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.Sci Rep 2018-05-17;8(1):7754.
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.Cell Rep 2018-05-01;23(5):1476-1490.
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.J. Clin. Invest. 2018-04-02;128(4):1597-1614.
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia.Cancer Discov 2018-04-01;8(4):478-497.
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.Brain Struct Funct 2018-04-01;223(3):1275-1296.
Monitoring ligand-dependent assembly of receptor ternary complexes in live cells by BRETFect.Proc. Natl. Acad. Sci. U.S.A. 2018-03-13;115(11):E2653-E2662.
Understanding diversity in telomere dynamics.Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2018-03-05;373(1741).
In medio stat virtus : unanticipated consequences of telomere dysequilibrium.Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2018-03-05;373(1741).
[Delivery in hypoxic tumor regions of a chemotherapeutic agent encapsulated in nanoliposomes carried by magnetoaerotactic bacteria].Med Sci (Paris) 2018-03-01;34(3):197-199.
MEK drives BRAF activation through allosteric control of KSR proteins.Nature 2018-02-22;554(7693):549-553.
CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.Oncotarget 2018-02-20;9(14):11646-11664.
Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin.Mol. Cell 2018-02-15;69(4):664-676.e5.
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.Cancer Res. 2018-02-15.
Ménière's Disease Pathophysiology: Endolymphatic Sac Immunohistochemical Study of Aquaporin-2, V2R Vasopressin Receptor, NKCC2, and TRPV4.Otolaryngol Head Neck Surg 2018-02-01:194599818756829.
Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy.Cell. Mol. Life Sci. 2018-02-01;75(4):607-621.
The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation.Cell Rep 2018-01-23;22(4):1016-1030.
The SysteMHC Atlas project.Nucleic Acids Res. 2018-01-04;46(D1):D1237-D1247.
Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase.Structure 2018-01-02;26(1):28-39.e2.
Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion.J. Virol. 2018-01-01;92(1).
A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome.Mol. Cell. Biol. 2018-01-01;38(1).
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