Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Checkpoint adaptation: Keeping Cdc5 in the T-loop.Serrano D, D'Amours DCell Cycle 2016-12-16;15(24):3339-3340.

Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JHNucleic Acids Res. 2016-12-15;44(22):10571-10587.

Improvement of Quantitative Measurements in Multiplex Proteomics Using High-Field Asymmetric Waveform Spectrometry.Pfammatter S, Bonneil E, Thibault PJ. Proteome Res. 2016-12-02;15(12):4653-4665.

MHC class I-associated peptides derive from selective regions of the human genome.Pearson H, Daouda T, Granados DP, Durette C, Bonneil E, Courcelles M, Rodenbrock A, Laverdure JP, Côté C, Mader S, Lemieux S, Thibault P, Perreault CJ. Clin. Invest. 2016-12-01;126(12):4690-4701.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang TJ. Clin. Invest. 2016-12-01;126(12):4569-4584.

Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.Grosset AA, Poirier F, Gaboury L, St-Pierre YPLoS ONE 2016-11-30;11(11):e0166731.

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism.Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers MSci Data 2016-11-22;3:160095.

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault VSci Rep 2016-11-22;5:37581.

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GDCell Chem Biol 2016-11-17;23(11):1383-1394.

Structural dynamics control the MicroRNA maturation pathway.Dallaire P, Tan H, Szulwach K, Ma C, Jin P, Major FNucleic Acids Res. 2016-11-16;44(20):9956-9964.

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.Orr B, Talje L, Liu Z, Kwok BH, Compton DACell Rep 2016-11-08;17(7):1755-1763.

A Pluridimensional View of Biased Agonism.Costa-Neto CM, Parreiras-E-Silva LT, Bouvier MMol. Pharmacol. 2016-11-01;90(5):587-595.

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.Felfoul O, Mohammadi M, Taherkhani S, de Lanauze D, Zhong Xu Y, Loghin D, Essa S, Jancik S, Houle D, Lafleur M, Gaboury L, Tabrizian M, Kaou N, Atkin M, Vuong T, Batist G, Beauchemin N, Radzioch D, Martel SNat Nanotechnol 2016-11-01;11(11):941-947.

Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.Tsao S, Weber S, Cameron C, Nehme D, Ahmadzadeh E, Raymond MJ. Antimicrob. Chemother. 2016-11-01;71(11):3125-3134.

ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche SOncogene 2016-10-27;35(43):5692-5698.

Introduction to the HUPO 2015 Special Issue.Borchers C, Thibault PJ Proteomics 2016-10-21;149:1-2.

Data Independent Acquisition analysis in ProHits 4.0.Liu G, Knight JD, Zhang JP, Tsou CC, Wang J, Lambert JP, Larsen B, Tyers M, Raught B, Bandeira N, Nesvizhskii AI, Choi H, Gingras ACJ Proteomics 2016-10-21;149:64-68.

The RTA3 Gene, Encoding a Putative Lipid Translocase, Influences the Susceptibility of Candida albicans to Fluconazole.Whaley SG, Tsao S, Weber S, Zhang Q, Barker KS, Raymond M, Rogers PDAntimicrob. Agents Chemother. 2016-10-01;60(10):6060-6.

Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons.Drouin A, Giguère S, Déraspe M, Marchand M, Tyers M, Loo VG, Bourgault AM, Laviolette F, Corbeil JBMC Genomics 2016-09-26;17(1):754.

Exploring Alternative RNA Structure Sets Using MC-Flashfold and db2cm.Dallaire P, Major FMethods Mol. Biol. 2016-09-25;1490:237-51.

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers.Rouette A, Trofimov A, Haberl D, Boucher G, Lavallée VP, D'Angelo G, Hébert J, Sauvageau G, Lemieux S, Perreault CSci Rep 2016-09-23;6:34019.

First case report of an adrenocortical carcinoma caused by a BRCA2 mutation.El Ghorayeb N, Grunenwald S, Nolet S, Primeau V, Côté S, Maugard CM, Lacroix A, Gaboury L, Bourdeau IMedicine (Baltimore) 2016-09-01;95(36):e4756.

BioCreative V BioC track overview: collaborative biocurator assistant task for BioGRID.Kim S, Islamaj Doğan R, Chatr-Aryamontri A, Chang CS, Oughtred R, Rust J, Batista-Navarro R, Carter J, Ananiadou S, Matos S, Santos A, Campos D, Oliveira JL, Singh O, Jonnagaddala J, Dai HJ, Su EC, Chang YC, Su YC, Chu CH, Chen CC, Hsu WL, Peng Y, Arighi C, Wu CH, Vijay-Shanker K, Aydın F, Hüsünbeyi ZM, Özgür A, Shin SY, Kwon D, Dolinski K, Tyers M, Wilbur WJ, Comeau DCDatabase (Oxford) 2016-09-01;2016:baw121.

Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard KAm. J. Obstet. Gynecol. 2016-09-01;215(3):384.e1-384.e89.

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.Venkatakrishnan AJ, Deupi X, Lebon G, Heydenreich FM, Flock T, Miljus T, Balaji S, Bouvier M, Veprintsev DB, Tate CG, Schertler GF, Babu MMNature 2016-08-25;536(7617):484-7.

ERAAP Shapes the Peptidome Associated with Classical and Nonclassical MHC Class I Molecules.Nagarajan NA, de Verteuil DA, Sriranganadane D, Yahyaoui W, Thibault P, Perreault C, Shastri NJ. Immunol. 2016-08-15;197(4):1035-43.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJCell 2016-08-11;166(4):907-19.

The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions.Borden KLTranslation (Austin) 2016-08-10;4(2):e1220899.

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien MPLoS Biol. 2016-08-01;14(8):e1002539.

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KWSci Signal 2016-07-26;9(438):ra75.

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura MJ. Biol. Chem. 2016-07-22;291(30):15641-52.

Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis.Mishra PK, Ciftci-Yilmaz S, Reynolds D, Au WC, Boeckmann L, Dittman LE, Jowhar Z, Pachpor T, Yeh E, Baker RE, Hoyt MA, D'Amours D, Bloom K, Basrai MAMol. Biol. Cell 2016-07-15;27(14):2286-300.

Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M, Fazel A, Bergeron JJ, Trudeau LE, Burelle Y, Gagnon E, McBride HM, Desjardins MCell 2016-07-14;166(2):314-27.

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan EProc. Natl. Acad. Sci. U.S.A. 2016-07-12;113(28):7786-91.

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET.Namkung Y, Le Gouill C, Lukashova V, Kobayashi H, Hogue M, Khoury E, Song M, Bouvier M, Laporte SANat Commun 2016-07-11;7:12178.

Unraveling Site-Specific and Combinatorial Histone Modifications Using High-Resolution Mass Spectrometry in Histone Deacetylase Mutants of Fission Yeast.Abshiru N, Rajan RE, Verreault A, Thibault PJ. Proteome Res. 2016-07-01;15(7):2132-42.

Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations.Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J, Sauvageau GLeukemia 2016-07-01;30(7):1621-4.

Redundancy in the World of MAP Kinases: All for One.Saba-El-Leil MK, Frémin C, Meloche SFront Cell Dev Biol 2016-06-27;4:67.

Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche SCell Cycle 2016-06-17;15(12):1631-42.

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau GBlood 2016-06-16;127(24):3054-61.

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.Dolma S, Selvadurai HJ, Lan X, Lee L, Kushida M, Voisin V, Whetstone H, So M, Aviv T, Park N, Zhu X, Xu C, Head R, Rowland KJ, Bernstein M, Clarke ID, Bader G, Harrington L, Brumell JH, Tyers M, Dirks PBCancer Cell 2016-06-13;29(6):859-73.

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy TSci Rep 2016-06-07;6:27379.

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets.Maiga A, Lemieux S, Pabst C, Lavallée VP, Bouvier M, Sauvageau G, Hébert JBlood Cancer J 2016-06-03;6(6):e431.

Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile.Patenaude J, Perreault CJ. Immunol. 2016-06-01;196(11):4760-70.

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers.Granados DP, Rodenbrock A, Laverdure JP, Côté C, Caron-Lizotte O, Carli C, Pearson H, Janelle V, Durette C, Bonneil E, Roy DC, Delisle JS, Lemieux S, Thibault P, Perreault CLeukemia 2016-06-01;30(6):1344-54.

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta AJ. Med. Chem. 2016-05-26;59(10):4697-710.

SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.Kota V, Sommer G, Durette C, Thibault P, van Niekerk EA, Twiss JL, Heise TPLoS ONE 2016-05-25;11(5):e0156365.

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Armstrong RN, Sauvageau G, Hébert JBlood 2016-05-19;127(20):2498-501.

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.Volpon L, Culjkovic-Kraljacic B, Osborne MJ, Ramteke A, Sun Q, Niesman A, Chook YM, Borden KLProc. Natl. Acad. Sci. U.S.A. 2016-05-10;113(19):5263-8.

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.Rentas S, Holzapfel NT, Belew MS, Pratt GA, Voisin V, Wilhelm BT, Bader GD, Yeo GW, Hope KJNature 2016-04-28;532(7600):508-11.

Myelopoiesis.Lessard JA., Hoang T.Encyclopedia of Immunobiology 2016-04-27;1:26-37.

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé FBlood 2016-04-21;127(16):2018-27.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin ABProc. Natl. Acad. Sci. U.S.A. 2016-04-19;113(16):4524-9.

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.Simoneau A, Ricard É, Weber S, Hammond-Martel I, Wong LH, Sellam A, Giaever G, Nislow C, Raymond M, Wurtele HNucleic Acids Res. 2016-04-07;44(6):2706-26.

Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets.Grosset AA, Labrie M, Vladoiu MC, Yousef EM, Gaboury L, St-Pierre YOncotarget 2016-04-05;7(14):18183-203.

Econazole imprinted textiles with antifungal activity.Hossain MA, Lalloz A, Benhaddou A, Pagniez F, Raymond M, Le Pape P, Simard P, Théberge K, Leblond JEur J Pharm Biopharm 2016-04-01;101:137-44.

Cellular localisation of the kinin B1R in the pancreas of streptozotocin-treated rat and the anti-diabetic effect of the antagonist SSR240612.Tidjane N, Gaboury L, Couture RBiol. Chem. 2016-04-01;397(4):323-36.

Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation.Ahmad I, LeBlanc R, Cohen S, Lachance S, Kiss T, Sauvageau G, Roy DC, Busque L, Delisle JS, Bambace N, Bernard L, Sabry W, Roy JBone Marrow Transplant. 2016-04-01;51(4):529-35.

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SSProc. Natl. Acad. Sci. U.S.A. 2016-03-29;113(13):3527-32.

ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.Schlienger S, Campbell S, Pasquin S, Gaboury L, Claing AOncotarget 2016-03-29;7(13):15811-27.

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.Lahaie N, Kralikova M, Prézeau L, Blahos J, Bouvier MJ. Biol. Chem. 2016-03-25;291(13):7156-70.

Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.Bannwarth S, Berg-Alonso L, Augé G, Fragaki K, Kolesar JE, Lespinasse F, Lacas-Gervais S, Burel-Vandenbos F, Villa E, Belmonte F, Michiels JF, Ricci JE, Gherardi R, Harrington L, Kaufman BA, Paquis-Flucklinger VMitochondrion 2016-02-23.

SCL/TAL1 in Hematopoiesis and Cellular Reprogramming.Hoang T, Lambert JA, Martin RCurr. Top. Dev. Biol. 2016-02-18;118:163-204.

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.Culjkovic-Kraljacic B, Fernando TM, Marullo R, Calvo-Vidal N, Verma A, Yang S, Tabbò F, Gaudiano M, Zahreddine H, Goldstein RL, Patel J, Taldone T, Chiosis G, Ladetto M, Ghione P, Machiorlatti R, Elemento O, Inghirami G, Melnick A, Borden KL, Cerchietti LBlood 2016-02-18;127(7):858-68.

Centrosome-Dependent Bypass of the DNA Damage Checkpoint by the Polo Kinase Cdc5.Ratsima H, Serrano D, Pascariu M, D'Amours DCell Rep 2016-02-16;14(6):1422-1434.

Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle.Wang P, Larouche M, Normandin K, Kachaner D, Mehsen H, Emery G, Archambault VCell Cycle 2016-02-16;15(4):528-39.

Bigger Isn't Always Better: Cell Size and the Spindle Assembly Checkpoint.Gerhold AR, Labbé JC, Maddox PSDev. Cell 2016-02-08;36(3):244-6.

The LMO2 oncogene regulates DNA replication in hematopoietic cells.Sincennes MC, Humbert M, Grondin B, Lisi V, Veiga DF, Haman A, Cazaux C, Mashtalir N, Affar el B, Verreault A, Hoang TProc. Natl. Acad. Sci. U.S.A. 2016-02-02;113(5):1393-8.

In vitro assay to determine SUMOylation sites on protein substrates.McManus FP, Altamirano CD, Thibault PNat Protoc 2016-02-01;11(2):387-97.

Lifelong leukocyte telomere dynamics and survival in a free-living mammal.Fairlie J, Holland R, Pilkington JG, Pemberton JM, Harrington L, Nussey DHAging Cell 2016-02-01;15(1):140-8.

Cellular and subcellular context determine outputs from signaling biosensors.Devost D, Audet N, Zhou C, Kobayashi H, Bonin H, Lukashova V, Le Gouill C, Bouvier M, Hébert TEMethods Cell Biol. 2016-01-29;132:319-37.

Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.Lebert-Ghali CÉ, Fournier M, Kettyle L, Thompson A, Sauvageau G, Bijl JJBlood 2016-01-07;127(1):87-90.

pyGeno: A Python package for precision medicine and proteogenomics.Daouda T, Perreault C, Lemieux SF1000Res 2016-01-01;5:381.

Cascade: an RNA-seq visualization tool for cancer genomics.Shifman AR, Johnson RM, Wilhelm BTBMC Genomics 2016-01-01;17(1):75.

BioGRID: A Resource for Studying Biological Interactions in Yeast.Oughtred R, Chatr-Aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers MCold Spring Harb Protoc 2016-01-01;2016(1):pdb.top080754.

Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.Oughtred R, Chatr-Aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers MCold Spring Harb Protoc 2016-01-01;2016(1):pdb.prot088880.

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.Laumont CM, Daouda T, Laverdure JP, Bonneil É, Caron-Lizotte O, Hardy MP, Granados DP, Durette C, Lemieux S, Thibault P, Perreault CNat Commun 2016-01-01;7:10238.

Placental Underperfusion in a Rat Model of Intrauterine Growth Restriction Induced by a Reduced Plasma Volume Expansion.Bibeau K, Sicotte B, Béland M, Bhat M, Gaboury L, Couture R, St-Louis J, Brochu MPLoS ONE 2016-01-01;11(1):e0145982.

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