Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers MCell Syst 2015-12-23;1(6):383-95.

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection.Dieudé M, Bell C, Turgeon J, Beillevaire D, Pomerleau L, Yang B, Hamelin K, Qi S, Pallet N, Béland C, Dhahri W, Cailhier JF, Rousseau M, Duchez AC, Lévesque T, Lau A, Rondeau C, Gingras D, Muruve D, Rivard A, Cardinal H, Perreault C, Desjardins M, Boilard É, Thibault P, Hébert MJSci Transl Med 2015-12-16;7(318):318ra200.

Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.Mendoza-Sanchez R, Cotnoir-White D, Kulpa J, Jutras I, Pottel J, Moitessier N, Mader S, Gleason JLBioorg. Med. Chem. 2015-12-15;23(24):7597-606.

DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.Narbonne P, Maddox PS, Labbé JCDevelopment 2015-12-15;142(24):4230-41.

The experimental power of FR900359 to study Gq-regulated biological processes.Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis ENat Commun 2015-12-14;6:10156.

The lighthouse at the end of the chromosome.Benslimane Y, Harrington LF1000Res 2015-12-11;4.

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GDCell Rep 2015-11-17;13(7):1481-92.

Association of Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and Hospital Admission Among Older Adults with Heart Failure.Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé M, Rouleau J, Tardif J, Jenna S, Haibe-Kains B, Leduc R, Deblois DValue Health 2015-11-01;18(7):A379.

Enhancement of mass spectrometry performance for proteomic analyses using high-field asymmetric waveform ion mobility spectrometry (FAIMS).Bonneil E, Pfammatter S, Thibault PJ Mass Spectrom 2015-11-01;50(11):1181-95.

Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra.Abshiru N, Caron-Lizotte O, Rajan RE, Jamai A, Pomies C, Verreault A, Thibault PNat Commun 2015-10-15;6:8648.

The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers.Légaré S, Cavallone L, Mamo A, Chabot C, Sirois I, Magliocco A, Klimowicz A, Tonin PN, Buchanan M, Keilty D, Hassan S, Laperrière D, Mader S, Aleynikova O, Basik MCancer Res. 2015-10-15;75(20):4351-63.

Cell cycle timing regulation during asynchronous divisions of the early C. elegans embryo.Tavernier N, Labbé JC, Pintard LExp. Cell Res. 2015-10-01;337(2):243-8.

β-Blockers have differential effects on the murine asthma phenotype.Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P, Bond RABr. J. Pharmacol. 2015-10-01;172(20):4833-46.

Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors.Giner XC, Cotnoir-White D, Mader S, Lévesque DFASEB J. 2015-10-01;29(10):4256-67.

Disclosure of incidental findings in cancer genomic research: investigators' perceptions on obligations and barriers.Kleiderman E, Avard D, Besso A, Ali-Khan S, Sauvageau G, Hébert JClin. Genet. 2015-10-01;88(4):320-6.

Understanding the Polo Kinase machine.Archambault V, Lépine G, Kachaner DOncogene 2015-09-10;34(37):4799-807.

Trapping cells in senescence with a lamin cage.Cordero G, D'Amours DCell Cycle 2015-09-02;14(17):2725-6.

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau GNat. Genet. 2015-09-01;47(9):1030-7.

Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4(+) T Cells after Allogeneic Stem Cell Transplantation.Gauthier SD, Leboeuf D, Manuguerra-Gagné R, Gaboury L, Guimond MBiol. Blood Marrow Transplant. 2015-09-01;21(9):1621-1632.

The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure.Bonneau E, Girard N, Lemieux S, Legault PRNA 2015-09-01;21(9):1621-32.

A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR, Bouvier M, Adjobo-Hermans MJMol. Pharmacol. 2015-09-01;88(3):589-95.

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier MProc. Natl. Acad. Sci. U.S.A. 2015-08-31.

Multiple Export Mechanisms for mRNAs.Delaleau M, Borden KLCells 2015-08-28;4(3):452-73.

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout VJ. Biol. Chem. 2015-08-21;290(34):21131-40.

MiRBooking simulates the stoichiometric mode of action of microRNAs.Weill N, Lisi V, Scott N, Dallaire P, Pelloux J, Major FNucleic Acids Res. 2015-08-18;43(14):6730-8.

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development.Frémin C, Saba-El-Leil MK, Lévesque K, Ang SL, Meloche SCell Rep 2015-08-11;12(6):913-21.

Sex hormones have pervasive effects on thymic epithelial cells.Dumont-Lagacé M, St-Pierre C, Perreault CSci Rep 2015-08-07;5:12895.

Frequency adaptation for enhanced radiation force amplitude in dynamic elastography.Ouared A, Montagnon E, Kazemirad S, Gaboury L, Robidoux A, Cloutier GIEEE Trans Ultrason Ferroelectr Freq Control 2015-08-01;62(8):1453-66.

Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.St-Pierre C, Trofimov A, Brochu S, Lemieux S, Perreault CJ. Immunol. 2015-07-15;195(2):498-506.

A Mutation in the Carbohydrate Recognition Domain Drives a Phenotypic Switch in the Role of Galectin-7 in Prostate Cancer.Labrie M, Vladoiu M, Leclerc BG, Grosset AA, Gaboury L, Stagg J, St-Pierre YPLoS ONE 2015-07-13;10(7):e0131307.

Sample Collection Method Bias Effects in Quantitative Phosphoproteomics.Kanshin E, Tyers M, Thibault PJ. Proteome Res. 2015-07-02;14(7):2998-3004.

Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.Santos GA, Duarte DA, Parreiras-E-Silva LT, Teixeira FR, Silva-Rocha R, Oliveira EB, Bouvier M, Costa-Neto CMFront Pharmacol 2015-07-01;6:131.

Small molecule regulation of normal and leukemic stem cells.Fares I, Rivest-Khan L, Cohen S, Sauvageau GCurr. Opin. Hematol. 2015-07-01;22(4):309-16.

Whole genome and transcriptome analysis of a novel AML cell line with a normal karyotype.Gosse G, Celton M, Lamontagne V, Forest A, Wilhelm BTLeuk. Res. 2015-07-01;39(7):709-18.

Translational control by oncogenic signaling pathways.Gao B, Roux PPBiochim. Biophys. Acta 2015-07-01;1849(7):753-765.

Caenorhabditis elegans is a useful model for anthelmintic discovery.Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJNat Commun 2015-06-25;6:7485.

The double capsules in macro-textured breast implants.Giot JP, Paek LS, Nizard N, El-Diwany M, Gaboury LA, Nelea M, Bou-Merhi JS, Harris PG, Danino MABiomaterials 2015-06-23;67:65-72.

Undetectable Histone O-GlcNAcylation in Mammalian Cells.Gagnon J, Daou S, Zamorano N, Ianantuono NV, Hammond-Martel I, Mashtalir N, Bonneil E, Wurtele H, Thibault P, Affar EBEpigenetics 2015-06-15:0.

Phosphoproteome dynamics of Saccharomyces cerevisiae under heat shock and cold stress.Kanshin E, Kubiniok P, Thattikota Y, D'Amours D, Thibault PMol. Syst. Biol. 2015-06-03;11(6):813.

RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures.Miao Z, Adamiak RW, Blanchet MF, Boniecki M, Bujnicki JM, Chen SJ, Cheng C, Chojnowski G, Chou FC, Cordero P, Cruz JA, Ferré-D'Amaré AR, Das R, Ding F, Dokholyan NV, Dunin-Horkawicz S, Kladwang W, Krokhotin A, Lach G, Magnus M, Major F, Mann TH, Masquida B, Matelska D, Meyer M, Peselis A, Popenda M, Purzycka KJ, Serganov A, Stasiewicz J, Szachniuk M, Tandon A, Tian S, Wang J, Xiao Y, Xu X, Zhang J, Zhao P, Zok T, Westhof ERNA 2015-06-01;21(6):1066-84.

The Added Value of Statistical Modeling of Backscatter Properties in the Management of Breast Lesions at US.Trop I, Destrempes F, El Khoury M, Robidoux A, Gaboury L, Allard L, Chayer B, Cloutier GRadiology 2015-06-01;275(3):666-74.

The Smc5-Smc6 heterodimer associates with DNA through several independent binding domains.Roy MA, Dhanaraman T, D'Amours DSci Rep 2015-05-18;5:9797.

Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells.Zahreddine HA, Borden KLClin. Cancer Res. 2015-05-15;21(10):2207-10.

Investigating the regulation of stem and progenitor cell mitotic progression by in situ imaging.Gerhold AR, Ryan J, Vallée-Trudeau JN, Dorn JF, Labbé JC, Maddox PSCurr. Biol. 2015-05-04;25(9):1123-34.

The Perlecan Fragment LG3 Regulates Homing of Mesenchymal Stem Cells and Neointima Formation During Vascular Rejection.Pilon EA, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert MJAm. J. Transplant. 2015-05-01;15(5):1205-18.

Interplay between histone h3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage.Simoneau A, Delgoshaie N, Celic I, Dai J, Abshiru N, Costantino S, Thibault P, Boeke JD, Verreault A, Wurtele HGenetics 2015-05-01;200(1):185-205.

The atypical MAPK ERK3 controls positive selection of thymocytes.Sirois J, Daudelin JF, Boulet S, Marquis M, Meloche S, Labrecque NImmunology 2015-05-01;145(1):161-9.

Regulation of RAF protein kinases in ERK signalling.Lavoie H, Therrien MNat. Rev. Mol. Cell Biol. 2015-04-23;16(5):281-98.

E4F1 Is a Master Regulator of CHK1-Mediated Functions.Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau GCell Rep 2015-04-15;11(2):210-219.

Proteome dynamics in health and disease.Thibault P, Gingras ACJ Proteomics 2015-04-06;118:1.

A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.Tidjane N, Hachem A, Zaid Y, Merhi Y, Gaboury L, Girolami JP, Couture REur J Inflamm 2015-04-01;13(1):40-52.

Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice.Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi RPLoS ONE 2015-03-24;10(3):e0119387.

[The 2010 years].Bouvier M, Chneiweiss H, Jordan B, Lagrue G, Ménard J, Teillaud JL, Kroemer G, Moulin AM, Flahault A, Lafanechère L, Maréchal É, Guillemot JC, Gaille MMed Sci (Paris) 2015-03-01;31 Spec No 1:91-111.

[The 2000 years].Peschanski M, Bergeron M, Boué A, Coppens Y, Changeux JP, Corvol P, Lazar P, Kahn A, Bichet DG, Friedlander G, Epelbaum J, Kroemer G, Chneiweiss H, Munnich A, Bouvier M, Jordan B, Frydman R, Morange M, Fougereau MMed Sci (Paris) 2015-03-01;31 Spec No 1:47-90.

The expanding role of mTOR in cancer cell growth and proliferation.Cargnello M, Tcherkezian J, Roux PPMutagenesis 2015-03-01;30(2):169-176.

Defective repair of uracil causes telomere defects in mouse hematopoietic cells.Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu YJ. Biol. Chem. 2015-02-27;290(9):5502-11.

Sonic Hedgehog factor Gli1: As good as resistant.Zahreddine HA, Culjkovic-Kraljacic B, Borden KLMol Cell Oncol 2015-02-24;2(1):e961827.

A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation.Kanshin E, Bergeron-Sandoval LP, Isik SS, Thibault P, Michnick SWCell Rep 2015-02-24;10(7):1202-14.

Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.Fortier S, MacRae T, Bilodeau M, Sargeant T, Sauvageau GProc. Natl. Acad. Sci. U.S.A. 2015-02-17;112(7):2127-32.

A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division.Robellet X, Thattikota Y, Wang F, Wee TL, Pascariu M, Shankar S, Bonneil É, Brown CM, D'Amours DGenes Dev. 2015-02-15;29(4):426-39.

Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing.Castonguay E, White SA, Kagansky A, St-Cyr DJ, Castillo AG, Brugger C, White R, Bonilla C, Spitzer M, Earnshaw WC, Schalch T, Ekwall K, Tyers M, Allshire RCMol. Cell. Biol. 2015-02-15;35(4):662-74.

CDK-1 and Two B-Type Cyclins Promote PAR-6 Stabilization during Polarization of the Early C. elegans Embryo.Rabilotta A, Desrosiers M, Labbé JCPLoS ONE 2015-02-06;10(2):e0117656.

Regulation of global and specific mRNA translation by the mTOR signaling pathway.Nandagopal N, Roux PPTranslation (Austin) 2015-02-02;3(1):e983402.

Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript.Wheeler EC, Washburn MC, Major F, Rusch DB, Hundley HARNA Biol 2015-02-01;12(2):162-74.

Syncytium biogenesis: It's all about maintaining good connections.Amini R, Chartier NT, Labbé JCWorm 2015-01-28;4(1):e992665.

The BioGRID interaction database: 2015 update.Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, Reguly T, Nixon J, Ramage L, Winter A, Sellam A, Chang C, Hirschman J, Theesfeld C, Rust J, Livstone MS, Dolinski K, Tyers MNucleic Acids Res. 2015-01-28;43(Database issue):D470-8.

Sentinel Node Biopsy After Neoadjuvant Chemotherapy in Biopsy-Proven Node-Positive Breast Cancer: The SN FNAC Study.Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, Karp SE, Trop I, Lisbona A, Wright FC, Younan RJ, Provencher L, Patocskai E, Omeroglu A, Robidoux AJ. Clin. Oncol. 2015-01-20;33(3):258-64.

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor i with chromatin.Jeffery DC, Kakusho N, You Z, Gharib M, Wyse B, Drury E, Weinreich M, Thibault P, Verreault A, Masai H, Yankulov KCell Cycle 2015-01-02;14(1):74-85.

In Vitro and In Vivo Characterization of the Rab11-GAP Activity of Drosophila Evi5.Laflamme C, Emery GMethods Mol. Biol. 2015-01-01;1298:187-94.

The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.Osborne MJ, Borden KLImmunol. Rev. 2015-01-01;263(1):210-23.

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien MNat. Struct. Mol. Biol. 2015-01-01;22(1):37-43.

A phase I trial of ribavirin and low-dose cytarabine for the treatment of relapsed and refractory acute myeloid leukemia with elevated eIF4E.Assouline S, Culjkovic-Kraljacic B, Bergeron J, Caplan S, Cocolakis E, Lambert C, Lau CJ, Zahreddine HA, Miller WH, Borden KLHaematologica 2015-01-01;100(1):e7-9.

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.Lavallée VP, Gendron P, Lemieux S, D'Angelo G, Hébert J, Sauvageau GBlood 2015-01-01;125(1):140-3.

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