Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
Development and Characterization of Pepducins as Gs-biased Allosteric Agonists.J. Biol. Chem. 2014-12-26;289(52):35668-84.
SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells.PLoS Genet. 2014-12-18;10(12):e1004768.
When Will Resistance Be Futile?Cancer Res. 2014-12-15;74(24):7175-7180.
Bloody signals: From birth to disease and death.Exp. Hematol. 2014-12-01;42(12):989-94.
The yeast polo kinase cdc5 regulates the shape of the mitotic nucleus.Curr. Biol. 2014-12-01;24(23):2861-7.
Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.Br. J. Pharmacol. 2014-12-01;171(23):5265-79.
Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation.DNA Repair (Amst.) 2014-11-24;25C:54-59.
Proteomic-Coupled-Network Analysis of T877A-Androgen Receptor Interactomes Can Predict Clinical Prostate Cancer Outcomes between White (Non-Hispanic) and African-American Groups.PLoS ONE 2014-11-19;9(11):e113190.
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Nat Commun 2014-11-18;5:5413.
Targeted protein degradation as a tumor suppressor.Cell Cycle 2014-11-15;13(22):3473.
The nature of self for T cells-a systems-level perspective.Curr. Opin. Immunol. 2014-11-15;34C:1-8.
Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.Nat Commun 2014-11-13;5:5409.
Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.Open Biol 2014-11-12;4(11).
MicroRNAs Expression in Triple Negative vs Non Triple Negative Breast Cancer in Tunisia: Interaction with Clinical Outcome.PLoS ONE 2014-11-04;9(11):e111877.
Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.BMC Cancer 2014-11-03;14:801.
Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases' occurrence.Med. Oncol. 2014-11-01;31(11):255.
Efficient sample processing for proteomics applications-Are we there yet?Mol. Syst. Biol. 2014-10-30;10(10):758.
Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.J. Cell Biol. 2014-10-27;207(2):201-11.
Defective IL-17- and IL-22-dependent mucosal host response to Candida albicans determines susceptibility to oral candidiasis in mice expressing the HIV-1 transgene.BMC Immunol. 2014-10-26;15(1):49.
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.Blood 2014-10-09;124(15):2362-9.
Structural Maintenance of Chromosome (SMC) Proteins Link Microtubule Stability to Genome Integrity.J. Biol. Chem. 2014-10-03;289(40):27418-31.
Break-induced replication requires DNA damage-induced phosphorylation of pif1 and leads to telomere lengthening.PLoS Genet. 2014-10-01;10(10):e1004679.
Dimerization-induced allostery in protein kinase regulation.Trends Biochem. Sci. 2014-10-01;39(10):475-486.
The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.FASEB J. 2014-10-01;28(10):4509-23.
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.Science 2014-09-19;345(6203):1509-12.
Expression and functions of galectin-7 in ovarian cancer.Oncotarget 2014-09-15;5(17):7705-21.
The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival.Mol. Cell. Biol. 2014-09-15;34(18):3374-87.
LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer.Int. J. Cancer 2014-09-15;135(6):1307-18.
Computational identification of RNA functional determinants by three-dimensional quantitative structure-activity relationships.Nucleic Acids Res. 2014-09-08;42(17):11261-71.
Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS.J. Biol. Chem. 2014-09-05;289(36):25262-75.
DEAD-box helicase DP103 defines metastatic potential of human breast cancers.J. Clin. Invest. 2014-09-02;124(9):3807-24.
When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage.Syst Synth Biol 2014-09-01;8(3):195-203.
Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine.J. Biol. Chem. 2014-08-29;289(35):24599-610.
KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation.J. Mol. Biol. 2014-08-26;426(17):2997-3015.
MMP-9 expression varies according to molecular subtypes of breast cancer.BMC Cancer 2014-08-23;14:609.
Inducible drug modification: A new form of resistance.Cell Cycle 2014-08-15;13(16):2485-6.
Self-renewal network activated by SCL-LMO1 confer aberrant stem cell properties to immature thymocytes.Exp. Hematol. 2014-08-01;42(8 Suppl):S64.
The immunopeptidome of normal and neoplastic cells.Exp. Hematol. 2014-08-01;42(8 Suppl):S5.
Long non-coding RNA expression in normal and leukemic human blood samples: Towards the identification of novel biomarkers and hematopoietic regulators.Exp. Hematol. 2014-08-01;42(8 Suppl):S45.
AML with EVI1 rearrangements are characterized by SF3B1 and IKZF1 mutations and distinct expression of MECOM isoforms.Exp. Hematol. 2014-08-01;42(8 Suppl):S44.
An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation.Exp. Hematol. 2014-08-01;42(8 Suppl):S4.
Exploring small molecules to expand human stem cells for transplantation.Exp. Hematol. 2014-08-01;42(8 Suppl):S2.
LMO1/2 regulates DNA replication in hematopoietic cells.Exp. Hematol. 2014-08-01;42(8 Suppl):S19.
Oncogenic transcription factors, from hematopoietic stem cells to thymocyte reprogramming.Exp. Hematol. 2014-08-01;42(8 Suppl):S11.
Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells.J. Immunol. 2014-08-01;193(3):1121-32.
Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.Leukemia 2014-08-01;28(8):1617-26.
TIF-90 tips the balance in rRNA synthesis.Blood 2014-07-24;124(4):467-8.
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.Proc. Natl. Acad. Sci. U.S.A. 2014-07-22;111(29):E2918-27.
Cellular control of cortical actin nucleation.Curr. Biol. 2014-07-21;24(14):1628-35.
A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.Nat Commun 2014-07-17;5:4431.
Structural basis for the recruitment of glycogen synthase by glycogenin.Proc. Natl. Acad. Sci. U.S.A. 2014-07-15;111(28):E2831-40.
Towards the development of chromone-based MEK1/2 modulators.Eur J Med Chem 2014-07-07;85C:127-138.
C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization.J. Cell Biol. 2014-07-07;206(1):129-143.
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.Nature 2014-07-03;511(7507):90-3.
Peripheral actions of GPCRs in energy homeostasis: view from the Chair.Int J Obes Suppl 2014-07-01;4(Suppl 1):S3-4.
Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function.J. Immunol. 2014-07-01;193(1):258-67.
Kit and Scl regulation of hematopoietic stem cells.Curr. Opin. Hematol. 2014-07-01;21(4):256-264.
Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1.Nucleic Acids Res. 2014-07-01;42(11):7012-27.
Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.Mol. Reprod. Dev. 2014-07-01;81(7):655-65.
Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.Pediatr. Res. 2014-07-01;76(1):24-32.
DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.FEBS Lett. 2014-06-27;588(14):2315-20.
N-Glycan-dependent and -independent Quality Control of Human δ Opioid Receptor N-terminal Variants.J. Biol. Chem. 2014-06-20;289(25):17830-17842.
Rebuttal from michel bouvier and terence e. Hébert.J. Physiol. (Lond.) 2014-06-15;592(Pt 12):2447.
CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers.J. Physiol. (Lond.) 2014-06-15;592(Pt 12):2439-41.
A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference.PLoS ONE 2014-06-05;9(6):e98431.
Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness.Am. J. Hum. Genet. 2014-06-05;94(6):891-7.
Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap1.Genetics 2014-06-03;197(4):1237-1250.
PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.J. Cell Biol. 2014-05-26;205(4):447-455.
Affinity purification of protein complexes from Drosophila embryos in cell cycle studies.Methods Mol. Biol. 2014-05-14;1170:571-88.
The Greatwall-PP2A axis in cell cycle control.Methods Mol. Biol. 2014-05-14;1170:99-111.
Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.J. Biol. Chem. 2014-05-09;289(19):13186-96.
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.Mol. Cell 2014-05-08;54(3):392-406.
In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.Dev. Cell 2014-04-28;29(2):203-16.
Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.Nat Commun 2014-04-09;5:3600.
Identification of small molecules that support human leukemia stem cell activity ex vivo.Nat. Methods 2014-04-01;11(4):436-42.
CNIH4 Interacts with Newly Synthesized GPCR and Controls Their Export from the Endoplasmic Reticulum.Traffic 2014-04-01;15(4):383-400.
Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle.FASEB J. 2014-04-01;28(4):1568-81.
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.Oncogene 2014-04-01;33(13):1690-9.
Biochemical properties of glycosylation and characterization of a histidine acid phosphatase (phytase) expressed in Pichia pastoris.Protein Expr. Purif. 2014-03-27;99C:43-49.
Ligand bias prevents class equality among beta-blockers.Curr Opin Pharmacol 2014-03-26;16C:50-57.
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.Blood 2014-03-13;123(11):1720-8.
A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.PLoS Biol. 2014-03-01;12(3):e1001809.
LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase.Cancer Res. 2014-03-01;74(5):1390-403.
Adult thymic epithelium contains nonsenescent label-retaining cells.J. Immunol. 2014-03-01;192(5):2219-26.
Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy.Mol. Pharmacol. 2014-03-01;85(3):492-509.
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.Genes Dev. 2014-02-15;28(4):357-71.
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.Genes Dev. 2014-02-15;28(4):317-27.
Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progression.Cell Cycle 2014-02-06;13(7).
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.Nat. Chem. Biol. 2014-02-01;10(2):156-63.
Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.Mol. Cell. Biol. 2014-02-01;34(3):362-73.
BoxPlotR: a web tool for generation of box plots.Nat. Methods 2014-01-30;11(2):121-2.
The Non-Classical MAP Kinase ERK3 Controls T Cell Activation.PLoS ONE 2014-01-27;9(1):e86681.
ERKs in Cancer: Friends or Foes?Cancer Res. 2014-01-15;74(2):412-9.
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.Mol. Cell Proteomics 2014-01-13;13(1):184-203.
Casein Kinase 1{varepsilon} Promotes Cell Proliferation by Regulating mRNA Translation.Cancer Res. 2014-01-01;74(1):201-11.
Rejection of leukemic cells requires antigen-specific t cells with high functional avidity.Biol. Blood Marrow Transplant. 2014-01-01;20(1):37-45.
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