Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists.Carr R, Du Y, Quoyer J, Panettieri RA, Janz JM, Bouvier M, Kobilka BK, Benovic JLJ. Biol. Chem. 2014-12-26;289(52):35668-84.

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells.Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang TPLoS Genet. 2014-12-18;10(12):e1004768.

When Will Resistance Be Futile?Borden KLCancer Res. 2014-12-15;74(24):7175-7180.

Bloody signals: From birth to disease and death.Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman TExp. Hematol. 2014-12-01;42(12):989-94.

The yeast polo kinase cdc5 regulates the shape of the mitotic nucleus.Walters AD, May CK, Dauster ES, Cinquin BP, Smith EA, Robellet X, D'Amours D, Larabell CA, Cohen-Fix OCurr. Biol. 2014-12-01;24(23):2861-7.

Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.Der Sarkissian S, Cailhier JF, Borie M, Stevens LM, Gaboury L, Mansour S, Hamet P, Noiseux NBr. J. Pharmacol. 2014-12-01;171(23):5265-79.

Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation.Fairlie J, Harrington LDNA Repair (Amst.) 2014-11-24;25C:54-59.

Proteomic-Coupled-Network Analysis of T877A-Androgen Receptor Interactomes Can Predict Clinical Prostate Cancer Outcomes between White (Non-Hispanic) and African-American Groups.Zaman N, Giannopoulos PN, Chowdhury S, Bonneil E, Thibault P, Wang E, Trifiro M, Paliouras MPLoS ONE 2014-11-19;9(11):e113190.

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RBNat Commun 2014-11-18;5:5413.

Targeted protein degradation as a tumor suppressor.Arat NO, Harrington LCell Cycle 2014-11-15;13(22):3473.

The nature of self for T cells-a systems-level perspective.Granados DP, Laumont CM, Thibault P, Perreault CCurr. Opin. Immunol. 2014-11-15;34C:1-8.

Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.Lamoliatte F, Caron D, Durette C, Mahrouche L, Maroui MA, Caron-Lizotte O, Bonneil E, Chelbi-Alix MK, Thibault PNat Commun 2014-11-13;5:5409.

Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.Gohard FH, St-Cyr DJ, Tyers M, Earnshaw WCOpen Biol 2014-11-12;4(11).

MicroRNAs Expression in Triple Negative vs Non Triple Negative Breast Cancer in Tunisia: Interaction with Clinical Outcome.Medimegh I, Omrane I, Privat M, Uhrhummer N, Ayari H, Belaiba F, Benayed F, Benromdhan K, Mader S, Bignon IJ, Elgaaied ABPLoS ONE 2014-11-04;9(11):e111877.

Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.Grosset AA, Labrie M, Gagné D, Vladoiu MC, Gaboury L, Doucet N, St-Pierre YBMC Cancer 2014-11-03;14:801.

Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases' occurrence.Medimegh I, Troudi W, Stambouli N, Khodjet-El-Khil H, Baroudi O, Ayari H, Omrane I, Uhrhammer N, Privat M, Mezlini A, Ayed FB, Romdhane KB, Mader S, Bignon YJ, Elgaaied ABMed. Oncol. 2014-11-01;31(11):255.

Efficient sample processing for proteomics applications-Are we there yet?Kanshin E, Thibault PMol. Syst. Biol. 2014-10-30;10(10):758.

Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.Kachaner D, Pinson X, El Kadhi KB, Normandin K, Talje L, Lavoie H, Lépine G, Carréno S, Kwok BH, Hickson GR, Archambault VJ. Cell Biol. 2014-10-27;207(2):201-11.

Defective IL-17- and IL-22-dependent mucosal host response to Candida albicans determines susceptibility to oral candidiasis in mice expressing the HIV-1 transgene.Goupil M, Cousineau-Côté V, Aumont F, Sénéchal S, Gaboury L, Hanna Z, Jolicoeur P, de Repentigny LBMC Immunol. 2014-10-26;15(1):49.

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau GBlood 2014-10-09;124(15):2362-9.

Structural Maintenance of Chromosome (SMC) Proteins Link Microtubule Stability to Genome Integrity.Laflamme G, Tremblay-Boudreault T, Roy MA, Andersen P, Bonneil E, Atchia K, Thibault P, D'Amours D, Kwok BHJ. Biol. Chem. 2014-10-03;289(40):27418-31.

Break-induced replication requires DNA damage-induced phosphorylation of pif1 and leads to telomere lengthening.Vasianovich Y, Harrington LA, Makovets SPLoS Genet. 2014-10-01;10(10):e1004679.

Dimerization-induced allostery in protein kinase regulation.Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri FTrends Biochem. Sci. 2014-10-01;39(10):475-486.

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier MFASEB J. 2014-10-01;28(10):4509-23.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau GScience 2014-09-19;345(6203):1509-12.

Expression and functions of galectin-7 in ovarian cancer.Labrie M, Vladoiu MC, Grosset AA, Gaboury L, St-Pierre YOncotarget 2014-09-15;5(17):7705-21.

The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival.Marquis M, Daudelin JF, Boulet S, Sirois J, Crain K, Mathien S, Turgeon B, Rousseau J, Meloche S, Labrecque NMol. Cell. Biol. 2014-09-15;34(18):3374-87.

LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer.Bouchekioua-Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, Bachelot T, Chabaud S, Mader S, Dayan G, Treilleux I, Corbo L, Le Romancer MInt. J. Cancer 2014-09-15;135(6):1307-18.

Computational identification of RNA functional determinants by three-dimensional quantitative structure-activity relationships.Blanchet MF, St-Onge K, Lisi V, Robitaille J, Hamel S, Major FNucleic Acids Res. 2014-09-08;42(17):11261-71.

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS.Beautrait A, Michalski KR, Lopez TS, Mannix KM, McDonald DJ, Cutter AR, Medina CB, Hebert AM, Francis CJ, Bouvier M, Tesmer JJ, Sterne-Marr RJ. Biol. Chem. 2014-09-05;289(36):25262-75.

DEAD-box helicase DP103 defines metastatic potential of human breast cancers.Shin EM, Sin Hay H, Lee MH, Goh JN, Tan TZ, Sen YP, Lim SW, Yousef EM, Ong HT, Thike AA, Kong X, Wu Z, Mendoz E, Sun W, Salto-Tellez M, Lim CT, Lobie PE, Lim YP, Yap CT, Zeng Q, Sethi G, Lee MB, Tan P, Goh BC, Miller LD, Thiery JP, Zhu T, Gaboury L, Tan PH, Hui KM, Yip GW, Miyamoto S, Kumar AP, Tergaonkar VJ. Clin. Invest. 2014-09-02;124(9):3807-24.

When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage.Serrano D, D'Amours DSyst Synth Biol 2014-09-01;8(3):195-203.

Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine.Ceraudo E, Galanth C, Carpentier E, Banegas-Font I, Schonegge AM, Alvear-Perez R, Iturrioz X, Bouvier M, Llorens-Cortes CJ. Biol. Chem. 2014-08-29;289(35):24599-610.

KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation.Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok BHJ. Mol. Biol. 2014-08-26;426(17):2997-3015.

MMP-9 expression varies according to molecular subtypes of breast cancer.Yousef EM, Tahir MR, St-Pierre Y, Gaboury LABMC Cancer 2014-08-23;14:609.

Inducible drug modification: A new form of resistance.Culjkovic-Kraljacic B, Zahreddine HA, Borden KLCell Cycle 2014-08-15;13(16):2485-6.

Self-renewal network activated by SCL-LMO1 confer aberrant stem cell properties to immature thymocytes.Veiga D, Gerby B, Hoang TExp. Hematol. 2014-08-01;42(8 Suppl):S64.

The immunopeptidome of normal and neoplastic cells.Perreault C, Granados D, Laumont C, Thibault PExp. Hematol. 2014-08-01;42(8 Suppl):S5.

Long non-coding RNA expression in normal and leukemic human blood samples: Towards the identification of novel biomarkers and hematopoietic regulators.Lehnertz B, Boucher G, Mallard W, Gendron P, Hebert J, Lemieux S, Rinn J, Sauvageau GExp. Hematol. 2014-08-01;42(8 Suppl):S45.

AML with EVI1 rearrangements are characterized by SF3B1 and IKZF1 mutations and distinct expression of MECOM isoforms.Lavallée VP, Boivin I, Armstrong RN, Lemieux S, Gendron P, Hebert J, Sauvageau GExp. Hematol. 2014-08-01;42(8 Suppl):S44.

An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation.Buscarlet M, Krasteva V, Ho L, Simon C, Hebert J, Wilhelm B, Crabtree G, Sauvageau G, Thibault P, Lessard JExp. Hematol. 2014-08-01;42(8 Suppl):S4.

Exploring small molecules to expand human stem cells for transplantation.Sauvageau GExp. Hematol. 2014-08-01;42(8 Suppl):S2.

LMO1/2 regulates DNA replication in hematopoietic cells.Humbert M, Sincennes MC, Grondin B, Haman A, Tremblay M, Verreault A, Hoang TExp. Hematol. 2014-08-01;42(8 Suppl):S19.

Oncogenic transcription factors, from hematopoietic stem cells to thymocyte reprogramming.Hoang TExp. Hematol. 2014-08-01;42(8 Suppl):S11.

Immunoproteasomes shape the transcriptome and regulate the function of dendritic Verteuil DA, Rouette A, Hardy MP, Lavallée S, Trofimov A, Gaucher E, Perreault CJ. Immunol. 2014-08-01;193(3):1121-32.

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.Celton M, Forest A, Gosse G, Lemieux S, Hebert J, Sauvageau G, Wilhelm BTLeukemia 2014-08-01;28(8):1617-26.

TIF-90 tips the balance in rRNA synthesis.Borden KLBlood 2014-07-24;124(4):467-8.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PPProc. Natl. Acad. Sci. U.S.A. 2014-07-22;111(29):E2918-27.

Cellular control of cortical actin nucleation.Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras GCurr. Biol. 2014-07-21;24(14):1628-35.

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MGNat Commun 2014-07-17;5:4431.

Structural basis for the recruitment of glycogen synthase by glycogenin.Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri FProc. Natl. Acad. Sci. U.S.A. 2014-07-15;111(28):E2831-40.

Towards the development of chromone-based MEK1/2 modulators.Redwan IN, Dyrager C, Solano C, Fernández de Trocóniz G, Voisin L, Bliman D, Meloche S, Grøtli MEur J Med Chem 2014-07-07;85C:127-138.

C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization.Amini R, Goupil E, Labella S, Zetka M, Maddox AS, Labbé JC, Chartier NTJ. Cell Biol. 2014-07-07;206(1):129-143.

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KLNature 2014-07-03;511(7507):90-3.

Peripheral actions of GPCRs in energy homeostasis: view from the Chair.Bouvier MInt J Obes Suppl 2014-07-01;4(Suppl 1):S3-4.

Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function.Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DAJ. Immunol. 2014-07-01;193(1):258-67.

Kit and Scl regulation of hematopoietic stem cells.Rojas-Sutterlin S, Lecuyer E, Hoang TCurr. Opin. Hematol. 2014-07-01;21(4):256-264.

Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1.Calderon MR, Verway M, Benslama RO, Birlea M, Bouttier M, Dimitrov V, Mader S, White JHNucleic Acids Res. 2014-07-01;42(11):7012-27.

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi RMol. Reprod. Dev. 2014-07-01;81(7):655-65.

Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups.Cuevas Guaman M, Sbrana E, Shope C, Showalter L, Hu M, Meloche S, Aagaard KPediatr. Res. 2014-07-01;76(1):24-32.

DHTP is an allosteric inhibitor of the kinesin-13 family of microtubule depolymerases.Talje L, Ben El Kadhi K, Atchia K, Tremblay-Boudreault T, Carreno S, Kwok BHFEBS Lett. 2014-06-27;588(14):2315-20.

N-Glycan-dependent and -independent Quality Control of Human δ Opioid Receptor N-terminal Variants.Lackman JJ, Markkanen PM, Hogue M, Bouvier M, Petäjä-Repo UEJ. Biol. Chem. 2014-06-20;289(25):17830-17842.

Rebuttal from michel bouvier and terence e. Hébert.Bouvier M, Hébert TEJ. Physiol. (Lond.) 2014-06-15;592(Pt 12):2447.

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers.Bouvier M, Hébert TEJ. Physiol. (Lond.) 2014-06-15;592(Pt 12):2439-41.

A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference.Beard PM, Griffiths SJ, Gonzalez O, Haga IR, Pechenick Jowers T, Reynolds DK, Wildenhain J, Tekotte H, Auer M, Tyers M, Ghazal P, Zimmer R, Haas JPLoS ONE 2014-06-05;9(6):e98431.

Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness.Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Décarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gérard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozet JM, Michaud JLAm. J. Hum. Genet. 2014-06-05;94(6):891-7.

Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap1.Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien MGenetics 2014-06-03;197(4):1237-1250.

PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.Benkemoun L, Descoteaux C, Chartier NT, Pintard L, Labbé JCJ. Cell Biol. 2014-05-26;205(4):447-455.

Affinity purification of protein complexes from Drosophila embryos in cell cycle studies.Lipinszki Z, Wang P, Grant R, Lindon C, Dzhindzhev NS, D'Avino PP, Przewloka MR, Glover DM, Archambault VMethods Mol. Biol. 2014-05-14;1170:571-88.

The Greatwall-PP2A axis in cell cycle control.Wang P, Malumbres M, Archambault VMethods Mol. Biol. 2014-05-14;1170:99-111.

Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.Delgoshaie N, Tang X, Kanshin ED, Williams EC, Rudner AD, Thibault P, Tyers M, Verreault AJ. Biol. Chem. 2014-05-09;289(19):13186-96.

Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el BMol. Cell 2014-05-08;54(3):392-406.

In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.Lacroix B, Bourdages KG, Dorn JF, Ihara S, Sherwood DR, Maddox PS, Maddox ASDev. Cell 2014-04-28;29(2):203-16.

Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.Granados DP, Sriranganadane D, Daouda T, Zieger A, Laumont CM, Caron-Lizotte O, Boucher G, Hardy MP, Gendron P, Côté C, Lemieux S, Thibault P, Perreault CNat Commun 2014-04-09;5:3600.

Identification of small molecules that support human leukemia stem cell activity ex vivo.Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau GNat. Methods 2014-04-01;11(4):436-42.

CNIH4 Interacts with Newly Synthesized GPCR and Controls Their Export from the Endoplasmic Reticulum.Sauvageau E, Rochdi MD, Oueslati M, Hamdan FF, Percherancier Y, Simpson JC, Pepperkok R, Bouvier MTraffic 2014-04-01;15(4):383-400.

Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle.Prunskaite-Hyyryläinen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJFASEB J. 2014-04-01;28(4):1568-81.

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SOOncogene 2014-04-01;33(13):1690-9.

Biochemical properties of glycosylation and characterization of a histidine acid phosphatase (phytase) expressed in Pichia pastoris.Fonseca-Maldonado R, Maller A, Bonneil E, Thibault P, Botelho-Machado C, Ward RJ, Polizeli MDProtein Expr. Purif. 2014-03-27;99C:43-49.

Ligand bias prevents class equality among beta-blockers.Thanawala VJ, Forkuo GS, Stallaert W, Leff P, Bouvier M, Bond RCurr Opin Pharmacol 2014-03-26;16C:50-57.

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JABlood 2014-03-13;123(11):1720-8.

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien MPLoS Biol. 2014-03-01;12(3):e1001809.

LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase.Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJCancer Res. 2014-03-01;74(5):1390-403.

Adult thymic epithelium contains nonsenescent label-retaining cells.Dumont-Lagacé M, Brochu S, St-Pierre C, Perreault CJ. Immunol. 2014-03-01;192(5):2219-26.

Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy.van der Westhuizen ET, Breton B, Christopoulos A, Bouvier MMol. Pharmacol. 2014-03-01;85(3):492-509.

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PPGenes Dev. 2014-02-15;28(4):357-71.

The methyltransferase G9a regulates HoxA9-dependent transcription in AML.Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FMGenes Dev. 2014-02-15;28(4):317-27.

Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progression.Simoneau A, Robellet X, Ladouceur AM, D'Amours DCell Cycle 2014-02-06;13(7).

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri FNat. Chem. Biol. 2014-02-01;10(2):156-63.

Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri FMol. Cell. Biol. 2014-02-01;34(3):362-73.

BoxPlotR: a web tool for generation of box plots.Spitzer M, Wildenhain J, Rappsilber J, Tyers MNat. Methods 2014-01-30;11(2):121-2.

The Non-Classical MAP Kinase ERK3 Controls T Cell Activation.Marquis M, Boulet S, Mathien S, Rousseau J, Thébault P, Daudelin JF, Rooney J, Turgeon B, Beauchamp C, Meloche S, Labrecque NPLoS ONE 2014-01-27;9(1):e86681.

ERKs in Cancer: Friends or Foes?Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre GCancer Res. 2014-01-15;74(2):412-9.

Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.Germain MA, Chatel-Chaix L, Gagné B, Bonneil E, Thibault P, Pradezynski F, de Chassey B, Meyniel-Schicklin L, Lotteau V, Baril M, Lamarre DMol. Cell Proteomics 2014-01-13;13(1):184-203.

Casein Kinase 1{varepsilon} Promotes Cell Proliferation by Regulating mRNA Translation.Shin S, Wolgamott L, Roux PP, Yoon SOCancer Res. 2014-01-01;74(1):201-11.

Rejection of leukemic cells requires antigen-specific t cells with high functional avidity.Vincent K, Hardy MP, Trofimov A, Laumont CM, Sriranganadane D, Hadj-Mimoune S, Salem Fourati I, Soudeyns H, Thibault P, Perreault CBiol. Blood Marrow Transplant. 2014-01-01;20(1):37-45.

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