Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW, Bouvier MProc. Natl. Acad. Sci. U.S.A. 2013-12-24;110(52):E5088-97.

The Coming of Age of Phosphoproteomics--from Large Data Sets to Inference of Protein Functions.Roux PP, Thibault PMol. Cell Proteomics 2013-12-01;12(12):3453-64.

Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and Intralipid solutions and correlation to insulin levels.d'Assignies G, Fontés G, Kauffmann C, Latour M, Gaboury L, Boulanger Y, Van Beers BE, Soulez G, Poitout V, Tang AMetab. Clin. Exp. 2013-12-01;62(12):1850-7.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EKCytoskeleton (Hoboken) 2013-11-01;70(11):741-54.

A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production.Chatel-Chaix L, Germain MA, Motorina A, Bonneil É, Thibault P, Baril M, Lamarre DJ. Virol. 2013-11-01;87(21):11704-20.

Regulation of Stress-Inducible Phosphoprotein 1 Nuclear Retention by Protein Inhibitor of Activated STAT PIAS1.Soares IN, Caetano FA, Pinder J, Rodrigues BR, Beraldo FH, Ostapchenko VG, Durette C, Pereira GS, Lopes MH, Queiroz-Hazarbassanov N, Cunha IW, Sanematsu PI, Suzuki S, Bleggi-Torres LF, Schild-Poulter C, Thibault P, Dellaire G, Martins VR, Prado VF, Prado MAMol. Cell Proteomics 2013-11-01;12(11):3253-70.

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, Michaud JLJ. Med. Genet. 2013-11-01;50(11):740-4.

Funding considerations for the disclosure of genetic incidental findings in biobank research.Black L, Avard D, Zawati M, Knoppers B, Hébert J, Sauvageau G, Clin. Genet. 2013-11-01;84(5):397-406.

Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism.Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette AJ. Biol. Chem. 2013-10-25;288(43):31165-76.

Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.Yoon SO, Roux PPCurr. Biol. 2013-10-07;23(19):R880-3.

The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia.Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden KLLeukemia 2013-10-01;27(10):2047-55.

RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.Ray-David H, Romeo Y, Lavoie G, Déléris P, Tcherkezian J, Galan JA, Roux PPOncogene 2013-09-19;32(38):4480-9.

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.Dormoy-Raclet V, Cammas A, Celona B, Lian XJ, van der Giessen K, Zivojnovic M, Brunelli S, Riuzzi F, Sorci G, Wilhelm BT, Marco SD, Donato R, Bianchi ME, Gallouzi IENat Commun 2013-09-04;4:2388.

Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma.Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden KL, Inghirami G, Leonard JP, Melnick A, Cerchietti LCancer Discov 2013-09-01;3(9):1002-1019.

Harnessing virtual machines to simplify next-generation DNA sequencing analysis.Nocq J, Celton M, Gendron P, Lemieux S, Wilhelm BTBioinformatics 2013-09-01;29(17):2075-83.

Targeted Identification of SUMOylation Sites in Human Proteins Using Affinity Enrichment and Paralog-specific Reporter Ions.Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenshuk H, Thibault PMol. Cell Proteomics 2013-09-01;12(9):2536-50.

Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages.Bell C, English L, Boulais J, Chemali M, Caron-Lizotte O, Desjardins M, Thibault PMol. Cell Proteomics 2013-09-01;12(9):2394-407.

Nystatin nanosizing enhances in vitro and in vivo antifungal activity against Candida albicans.Melkoumov A, Goupil M, Louhichi F, Raymond M, de Repentigny L, Leclair GJ. Antimicrob. Chemother. 2013-09-01;68(9):2099-105.

Engineering the Pattern of Protein Glycosylation Modulates the Thermostability of a GH11 Xylanase.Fonseca-Maldonado R, Vieira DS, Alponti JS, Bonneil E, Thibault P, Ward RJJ. Biol. Chem. 2013-08-30;288(35):25522-34.

RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault E, Macrae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau GBlood 2013-08-29;122(9):1545-55.

Genetic interaction between Kit and Scl.Lacombe J, Krosl G, Tremblay M, Gerby B, Martin R, Aplan PD, Lemieux S, Hoang TBlood 2013-08-15;122(7):1150-61.

RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang TProc. Natl. Acad. Sci. U.S.A. 2013-08-13;110(33):13522-7.

The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.Solinet S, Mahmud K, Stewman SF, Ben El Kadhi K, Decelle B, Talje L, Ma A, Kwok BH, Carreno SJ. Cell Biol. 2013-07-22;202(2):251-60.

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.Wang P, Galan JA, Normandin K, Bonneil E, Hickson GR, Roux PP, Thibault P, Archambault VJ. Cell Biol. 2013-07-22;202(2):277-93.

Leishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8.Matheoud D, Moradin N, Bellemare-Pelletier A, Shio MT, Hong WJ, Olivier M, Gagnon E, Desjardins M, Descoteaux ACell Host Microbe 2013-07-17;14(1):15-25.

Cell coordination of collective migration by Rab11 and Moesin.Emery G, Ramel DCommun Integr Biol 2013-07-01;6(4):e24587.

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien MNat. Chem. Biol. 2013-07-01;9(7):428-36.

Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.Ramsey JM, Kettyle LM, Sharpe DJ, Mulgrew NM, Dickson GJ, Bijl JJ, Austin P, Mayotte N, Cellot S, Lappin TR, Zhang SD, Mills KI, Krosl J, Sauvageau G, Thompson AStem Cells 2013-07-01;31(7):1434-45.

Aiding and abetting cancer: mRNA export and the nuclear pore.Culjkovic-Kraljacic B, Borden KLTrends Cell Biol. 2013-07-01;23(7):328-35.

Positive regulation of insulin signaling by neuraminidase 1.Dridi L, Seyrantepe V, Fougerat A, Pan X, Bonneil E, Thibault P, Moreau A, Mitchell GA, Heveker N, Cairo CW, Issad T, Hinek A, Pshezhetsky AVDiabetes 2013-07-01;62(7):2338-46.

NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang JBlood 2013-06-27;121(26):5203-7.

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KL, Meloche S, Roux PPOncogene 2013-06-13;32(24):2917-26.

Displacement of N/Q-rich Peptides on TiO2 Beads Enhances the Depth and Coverage of Yeast Phosphoproteome Analyses.Kanshin E, Michnick SW, Thibault PJ. Proteome Res. 2013-06-07;12(6):2905-13.

Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses.Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre DPLoS Pathog. 2013-06-01;9(6):e1003416.

Transcriptome sequencing of neonatal thymic epithelial cells.St-Pierre C, Brochu S, Vanegas JR, Dumont-Lagacé M, Lemieux S, Perreault CSci Rep 2013-05-17;3:1860.

GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.Fernández-Espartero CH, Ramel D, Farago M, Malartre M, Luque CM, Limanovich S, Katzav S, Emery G, Martín-Bermudo MDJ. Cell. Sci. 2013-05-15;126(Pt 10):2285-93.

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.Volpon L, Osborne MJ, Zahreddine H, Romeo AA, Borden KLBiochem. Biophys. Res. Commun. 2013-05-10;434(3):614-9.

Octameric CENP-A Nucleosomes Are Present at Human Centromeres throughout the Cell Cycle.Padeganeh A, Ryan J, Boisvert J, Ladouceur AM, Dorn JF, Maddox PSCurr. Biol. 2013-05-06;23(9):764-9.

Unraveling the structural basis of GPCR activation and inactivation.Bouvier MNat. Struct. Mol. Biol. 2013-05-01;20(5):539-41.

The Oncogene eIF4E: Using Biochemical Insights to Target Cancer.Carroll M, Borden KLJ. Interferon Cytokine Res. 2013-05-01;33(5):227-38.

Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.Deneault E, Wilhelm BT, Bergeron A, Barabé F, Sauvageau GExp. Hematol. 2013-05-01;41(5):470-478.e4.

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre GGenes Dev. 2013-04-15;27(8):900-15.

eIF4E3, a new actor in mRNA metabolism and tumor suppression.Volpon L, Osborne MJ, Culjkovic-Kraljacic B, Borden KLCell Cycle 2013-04-15;12(8):1159-60.

Proteomics: From protein structures to clinical applications.Thibault P, Marshall JJ Proteomics 2013-04-09;81:1-2.

Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.Abshiru N, Ippersiel K, Tang Y, Yuan H, Marmorstein R, Verreault A, Thibault PJ Proteomics 2013-04-09;81:80-90.

Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells.Gerby B, Hoang TBMC Proc 2013-04-04;7(Suppl 2 Sao Paulo Advanced School of Comparative Oncology: AbstractsClaudia Aparecida Rainho, Patricia Pintor dos Reis and Silvia Regina RogattoPublication of this supplement was funded by the Sao Paulo Research Foundation (FAPESP)):K1.

Short Telomeres in ESCs Lead to Unstable Differentiation.Pucci F, Gardano L, Harrington LCell Stem Cell 2013-04-04;12(4):479-86.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DWChromosome Res. 2013-04-01;21(2):101-6.

A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.Pallet N, Sirois I, Bell C, Hanafi LA, Hamelin K, Dieudé M, Rondeau C, Thibault P, Desjardins M, Hebert MJProteomics 2013-04-01;13(7):1108-20.

The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.Khan SM, Sleno R, Gora S, Zylbergold P, Laverdure JP, Labbé JC, Miller GJ, Hébert TEPharmacol. Rev. 2013-04-01;65(2):545-77.

Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility.Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PPMol. Cell. Biol. 2013-04-01;33(8):1657-70.

Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.Leongson K, Cousineau-Côté V, Goupil M, Aumont F, Sénéchal S, Gaboury L, Jolicoeur P, Kronstad JW, de Repentigny LInfect. Immun. 2013-04-01;81(4):1100-13.

Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma.Holbro A, Ahmad I, Cohen S, Roy J, Lachance S, Chagnon M, LeBlanc R, Bernard L, Busque L, Roy DC, Sauvageau G, Kiss TLBiol. Blood Marrow Transplant. 2013-04-01;19(4):547-51.

A yeast chemical genetic screen identifies inhibitors of human telomerase.Wong LH, Unciti-Broceta A, Spitzer M, White R, Tyers M, Harrington LChem. Biol. 2013-03-21;20(3):333-40.

Cancer: Trouble upstream.Patton EE, Harrington LNature 2013-03-21;495(7441):320-1.

Michel j. Bertrand (1945-2012).Perreault H, Thibault PRapid Commun. Mass Spectrom. 2013-03-15;27(5):654.

eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KLProc. Natl. Acad. Sci. U.S.A. 2013-03-05;110(10):3877-82.

Rab11 regulates cell-cell communication during collective cell movements.Ramel D, Wang X, Laflamme C, Montell DJ, Emery GNat. Cell Biol. 2013-03-01;15(3):317-24.

Insights into the insect salivary gland proteome: diet-associated changes in caterpillar labial salivary proteins.Afshar K, Dube FF, Najafabadi HS, Bonneil E, Thibault P, Salavati R, Bede JCJ. Insect Physiol. 2013-03-01;59(3):351-66.

Nucleosomal composition at the centromere: a numbers game.Padeganeh A, De Rop V, Maddox PSChromosome Res. 2013-03-01;21(1):27-36.

The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.Delisle JS, Giroux M, Boucher G, Landry JR, Hardy MP, Lemieux S, Jones RG, Wilhelm BT, Perreault CGenes Immun. 2013-03-01;14(2):115-26.

Dividing in Epithelia: Cells Let Loose during Cytokinesis.Bourdages KG, Maddox ASDev. Cell 2013-02-25;24(4):336-8.

Proteomics analysis of Herpes Simplex Virus type 1-infected cells reveals dynamic changes of viral protein expression, ubiquitylation and phosphorylation.Bell C, Desjardins M, Thibault P, Radtke KJ. Proteome Res. 2013-02-18;12(4):1820-29.

Bioinactive ACTH causing glucocorticoid deficiency.Samuels ME, Gallo-Payet N, Pinard S, Hasselmann C, Magne F, Patry L, Chouinard L, Schwartzentruber J, René P, Sawyer N, Bouvier M, Djemli A, Delvin E, Huot C, Eugene D, Deal CL, Van Vliet G, Majewski J, Deladoëy J, J. Clin. Endocrinol. Metab. 2013-02-01;98(2):736-42.

A strategy for modulation of enzymes in the ubiquitin system.Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SSScience 2013-02-01;339(6119):590-5.

Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.Richard-Lalonde M, Nagi K, Audet N, Sleno R, Amraei M, Hogue M, Balboni G, Schiller PW, Bouvier M, Hébert TE, Pineyro GMol. Pharmacol. 2013-02-01;83(2):416-28.

In search of immunodominant minor histocompatibility antigens.Perreault CBiol. Blood Marrow Transplant. 2013-02-01;19(2):171-2.

Autism-related deficits via dysregulated eIF4E-dependent translational control.Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg NNature 2013-01-17;493(7432):371-7.

Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.Rafei M, Rouette A, Brochu S, Vanegas JR, Perreault CBlood 2013-01-03;121(1):107-17.

A rare case of large skull base meningioma mimicking otitis media with effusion.Alzahrani M, Gaboury L, Saliba ICase Rep Med 2013-01-01;2013:396805.

Comparative xylose metabolism among the Ascomycetes C. albicans, S. stipitis and S. cerevisiae.Harcus D, Dignard D, Lépine G, Askew C, Raymond M, Whiteway M, Wu CPLoS ONE 2013-01-01;8(11):e80733.

RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells.Macrae T, Sargeant T, Lemieux S, Hébert J, Deneault E, Sauvageau GPLoS ONE 2013-01-01;8(9):e72884.

Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.Schann S, Bouvier M, Neuville PDrug Discov Today Technol 2013-01-01;10(2):e261-7.

Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy.Rafei M, Dumont-Lagacé M, Rouette A, Perreault CPLoS ONE 2013-01-01;8(9):e72801.

Telomeres, a busy platform for cell signaling.Gardano L, Pucci F, Christian L, Le Bihan T, Harrington LFront Oncol 2013-01-01;3:146.

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault PMol. Syst. Biol. 2013-01-01;9:669.

The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update.Sadowski I, Breitkreutz BJ, Stark C, Su TC, Dahabieh M, Raithatha S, Bernhard W, Oughtred R, Dolinski K, Barreto K, Tyers MDatabase (Oxford) 2013-01-01;2013(0):bat026.

Expression and functions of galectin-7 in human and murine melanomas.Biron-Pain K, Grosset AA, Poirier F, Gaboury L, St-Pierre YPLoS ONE 2013-01-01;8(5):e63307.

Systematic curation of protein and genetic interaction data for computable biology.Dolinski K, Chatr-Aryamontri A, Tyers MBMC Biol. 2013-01-01;11:43.

Correction of spatial bias in oligonucleotide array data.Serhal P, Lemieux SAdv Bioinformatics 2013-01-01;2013:167915.

Mechanisms and insights into drug resistance in cancer.Zahreddine H, Borden KLFront Pharmacol 2013-01-01;4:28.

The BioGRID interaction database: 2013 update.Chatr-Aryamontri A, Breitkreutz BJ, Heinicke S, Boucher L, Winter A, Stark C, Nixon J, Ramage L, Kolas N, O'Donnell L, Reguly T, Breitkreutz A, Sellam A, Chen D, Chang C, Rust J, Livstone M, Oughtred R, Dolinski K, Tyers MNucleic Acids Res. 2013-01-01;41(Database issue):D816-23.

Drosophila s2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes.Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JPTraffic 2013-01-01;14(1):82-96.

Improved antifungal activity of itraconazole-loaded PEG/PLA nanoparticles.Essa S, Louhichi F, Raymond M, Hildgen PJ Microencapsul 2013-01-01;30(3):205-17.

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