Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.Proc. Natl. Acad. Sci. U.S.A. 2013-12-24;110(52):E5088-97.
The Coming of Age of Phosphoproteomics--from Large Data Sets to Inference of Protein Functions.Mol. Cell Proteomics 2013-12-01;12(12):3453-64.
Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and Intralipid solutions and correlation to insulin levels.Metab. Clin. Exp. 2013-12-01;62(12):1850-7.
Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.Cytoskeleton (Hoboken) 2013-11-01;70(11):741-54.
A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production.J. Virol. 2013-11-01;87(21):11704-20.
Regulation of Stress-Inducible Phosphoprotein 1 Nuclear Retention by Protein Inhibitor of Activated STAT PIAS1.Mol. Cell Proteomics 2013-11-01;12(11):3253-70.
Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.J. Med. Genet. 2013-11-01;50(11):740-4.
Funding considerations for the disclosure of genetic incidental findings in biobank research.Clin. Genet. 2013-11-01;84(5):397-406.
Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism.J. Biol. Chem. 2013-10-25;288(43):31165-76.
Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.Curr. Biol. 2013-10-07;23(19):R880-3.
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia.Leukemia 2013-10-01;27(10):2047-55.
RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.Oncogene 2013-09-19;32(38):4480-9.
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.Nat Commun 2013-09-04;4:2388.
Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma.Cancer Discov 2013-09-01;3(9):1002-1019.
Harnessing virtual machines to simplify next-generation DNA sequencing analysis.Bioinformatics 2013-09-01;29(17):2075-83.
Targeted Identification of SUMOylation Sites in Human Proteins Using Affinity Enrichment and Paralog-specific Reporter Ions.Mol. Cell Proteomics 2013-09-01;12(9):2536-50.
Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages.Mol. Cell Proteomics 2013-09-01;12(9):2394-407.
Nystatin nanosizing enhances in vitro and in vivo antifungal activity against Candida albicans.J. Antimicrob. Chemother. 2013-09-01;68(9):2099-105.
Engineering the Pattern of Protein Glycosylation Modulates the Thermostability of a GH11 Xylanase.J. Biol. Chem. 2013-08-30;288(35):25522-34.
RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Blood 2013-08-29;122(9):1545-55.
Genetic interaction between Kit and Scl.Blood 2013-08-15;122(7):1150-61.
RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.Proc. Natl. Acad. Sci. U.S.A. 2013-08-13;110(33):13522-7.
The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex.J. Cell Biol. 2013-07-22;202(2):251-60.
Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression.J. Cell Biol. 2013-07-22;202(2):277-93.
Leishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8.Cell Host Microbe 2013-07-17;14(1):15-25.
Cell coordination of collective migration by Rab11 and Moesin.Commun Integr Biol 2013-07-01;6(4):e24587.
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.Nat. Chem. Biol. 2013-07-01;9(7):428-36.
Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.Stem Cells 2013-07-01;31(7):1434-45.
Aiding and abetting cancer: mRNA export and the nuclear pore.Trends Cell Biol. 2013-07-01;23(7):328-35.
Positive regulation of insulin signaling by neuraminidase 1.Diabetes 2013-07-01;62(7):2338-46.
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Blood 2013-06-27;121(26):5203-7.
RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.Oncogene 2013-06-13;32(24):2917-26.
Displacement of N/Q-rich Peptides on TiO2 Beads Enhances the Depth and Coverage of Yeast Phosphoproteome Analyses.J. Proteome Res. 2013-06-07;12(6):2905-13.
Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses.PLoS Pathog. 2013-06-01;9(6):e1003416.
Transcriptome sequencing of neonatal thymic epithelial cells.Sci Rep 2013-05-17;3:1860.
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.J. Cell. Sci. 2013-05-15;126(Pt 10):2285-93.
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.Biochem. Biophys. Res. Commun. 2013-05-10;434(3):614-9.
Octameric CENP-A Nucleosomes Are Present at Human Centromeres throughout the Cell Cycle.Curr. Biol. 2013-05-06;23(9):764-9.
Unraveling the structural basis of GPCR activation and inactivation.Nat. Struct. Mol. Biol. 2013-05-01;20(5):539-41.
The Oncogene eIF4E: Using Biochemical Insights to Target Cancer.J. Interferon Cytokine Res. 2013-05-01;33(5):227-38.
Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.Exp. Hematol. 2013-05-01;41(5):470-478.e4.
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.Genes Dev. 2013-04-15;27(8):900-15.
eIF4E3, a new actor in mRNA metabolism and tumor suppression.Cell Cycle 2013-04-15;12(8):1159-60.
Proteomics: From protein structures to clinical applications.J Proteomics 2013-04-09;81:1-2.
Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.J Proteomics 2013-04-09;81:80-90.
Modelling acute leukemias in mice: clonal evolution and the emergence of leukemic stem cells.BMC Proc 2013-04-04;7(Suppl 2 Sao Paulo Advanced School of Comparative Oncology: AbstractsClaudia Aparecida Rainho, Patricia Pintor dos Reis and Silvia Regina RogattoPublication of this supplement was funded by the Sao Paulo Research Foundation (FAPESP)):K1.
Short Telomeres in ESCs Lead to Unstable Differentiation.Cell Stem Cell 2013-04-04;12(4):479-86.
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.Chromosome Res. 2013-04-01;21(2):101-6.
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.Proteomics 2013-04-01;13(7):1108-20.
The expanding roles of Gβγ subunits in G protein-coupled receptor signaling and drug action.Pharmacol. Rev. 2013-04-01;65(2):545-77.
Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility.Mol. Cell. Biol. 2013-04-01;33(8):1657-70.
Altered immune response differentially enhances susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in mice expressing the HIV-1 transgene.Infect. Immun. 2013-04-01;81(4):1100-13.
Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma.Biol. Blood Marrow Transplant. 2013-04-01;19(4):547-51.
A yeast chemical genetic screen identifies inhibitors of human telomerase.Chem. Biol. 2013-03-21;20(3):333-40.
Cancer: Trouble upstream.Nature 2013-03-21;495(7441):320-1.
Michel j. Bertrand (1945-2012).Rapid Commun. Mass Spectrom. 2013-03-15;27(5):654.
eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.Proc. Natl. Acad. Sci. U.S.A. 2013-03-05;110(10):3877-82.
Rab11 regulates cell-cell communication during collective cell movements.Nat. Cell Biol. 2013-03-01;15(3):317-24.
Insights into the insect salivary gland proteome: diet-associated changes in caterpillar labial salivary proteins.J. Insect Physiol. 2013-03-01;59(3):351-66.
Nucleosomal composition at the centromere: a numbers game.Chromosome Res. 2013-03-01;21(1):27-36.
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.Genes Immun. 2013-03-01;14(2):115-26.
Dividing in Epithelia: Cells Let Loose during Cytokinesis.Dev. Cell 2013-02-25;24(4):336-8.
Proteomics analysis of Herpes Simplex Virus type 1-infected cells reveals dynamic changes of viral protein expression, ubiquitylation and phosphorylation.J. Proteome Res. 2013-02-18;12(4):1820-29.
Bioinactive ACTH causing glucocorticoid deficiency.J. Clin. Endocrinol. Metab. 2013-02-01;98(2):736-42.
A strategy for modulation of enzymes in the ubiquitin system.Science 2013-02-01;339(6119):590-5.
Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors.Mol. Pharmacol. 2013-02-01;83(2):416-28.
In search of immunodominant minor histocompatibility antigens.Biol. Blood Marrow Transplant. 2013-02-01;19(2):171-2.
Autism-related deficits via dysregulated eIF4E-dependent translational control.Nature 2013-01-17;493(7432):371-7.
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.Blood 2013-01-03;121(1):107-17.
A rare case of large skull base meningioma mimicking otitis media with effusion.Case Rep Med 2013-01-01;2013:396805.
Comparative xylose metabolism among the Ascomycetes C. albicans, S. stipitis and S. cerevisiae.PLoS ONE 2013-01-01;8(11):e80733.
RNA-Seq Reveals Spliceosome and Proteasome Genes as Most Consistent Transcripts in Human Cancer Cells.PLoS ONE 2013-01-01;8(9):e72884.
Technology combination to address GPCR allosteric modulator drug-discovery pitfalls.Drug Discov Today Technol 2013-01-01;10(2):e261-7.
Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy.PLoS ONE 2013-01-01;8(9):e72801.
Telomeres, a busy platform for cell signaling.Front Oncol 2013-01-01;3:146.
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions.Mol. Syst. Biol. 2013-01-01;9:669.
The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update.Database (Oxford) 2013-01-01;2013(0):bat026.
Expression and functions of galectin-7 in human and murine melanomas.PLoS ONE 2013-01-01;8(5):e63307.
Systematic curation of protein and genetic interaction data for computable biology.BMC Biol. 2013-01-01;11:43.
Correction of spatial bias in oligonucleotide array data.Adv Bioinformatics 2013-01-01;2013:167915.
Mechanisms and insights into drug resistance in cancer.Front Pharmacol 2013-01-01;4:28.
The BioGRID interaction database: 2013 update.Nucleic Acids Res. 2013-01-01;41(Database issue):D816-23.
Drosophila s2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes.Traffic 2013-01-01;14(1):82-96.
Improved antifungal activity of itraconazole-loaded PEG/PLA nanoparticles.J Microencapsul 2013-01-01;30(3):205-17.
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