Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno SCurr. Biol. 2011-06-21;21(12):1074-9.

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GDNat. Chem. Biol. 2011-06-01;7(6):348-50.

Cell size: chromosomes get slapped by a midzone ruler.Ladouceur AM, Ranjan R, Maddox PSCurr. Biol. 2011-05-24;21(10):R388-90.

G protein-coupled receptor modulation with pepducins: moving closer to the clinic.Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SWAnn. N. Y. Acad. Sci. 2011-05-01;1226:34-49.

Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.Pettersson F, Yau C, Dobocan MC, Culjkovic-Kraljacic B, Retrouvay H, Puckett R, Flores LM, Krop IE, Rousseau C, Cocolakis E, Borden KL, Benz CC, Miller WHClin. Cancer Res. 2011-05-01;17(9):2874-84.

Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Schubert S, Barker KS, Znaidi S, Schneider S, Dierolf F, Dunkel N, Aïd M, Boucher G, Rogers PD, Raymond M, Morschhäuser JAntimicrob. Agents Chemother. 2011-05-01;55(5):2212-23.

Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation.Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel SBiomaterials 2011-05-01;32(13):3481-6.

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema KJ. Cell Biol. 2011-04-04;193(1):155-69.

An anticlastogenic function for the Polycomb Group gene Bmi1.Chagraoui J, Hébert J, Girard S, Sauvageau GProc. Natl. Acad. Sci. U.S.A. 2011-03-29;108(13):5284-9.

Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LEJ. Biol. Chem. 2011-03-18;286(11):9360-72.

H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJPLoS Genet. 2011-03-01;7(3):e1001354.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Cargnello M, Roux PPMicrobiol. Mol. Biol. Rev. 2011-03-01;75(1):50-83.

Evolution of the repertoire of nuclear receptor binding sites in genomes.Cotnoir-White D, Laperrière D, Mader SMol. Cell. Endocrinol. 2011-03-01;334(1-2):76-82.

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche SJ. Biol. Chem. 2011-02-25;286(8):6470-8.

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Chartier NT, Salazar Ospina DP, Benkemoun L, Mayer M, Grill SW, Maddox AS, Labbé JCCurr. Biol. 2011-02-22;21(4):259-69.

Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex.Roy MA, Siddiqui N, D'Amours DCell Cycle 2011-02-15;10(4):690-700.

Fitness without exhaustion.Perreault CBlood 2011-02-10;117(6):1776.

Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.Tang Y, Holbert MA, Delgoshaie N, Wurtele H, Guillemette B, Meeth K, Yuan H, Drogaris P, Lee EH, Durette C, Thibault P, Verreault A, Cole PA, Marmorstein RStructure 2011-02-09;19(2):221-31.

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.Giroux M, Delisle JS, Gauthier SD, Heinonen KM, Hinsinger J, Houde B, Gaboury L, Brochu S, Wu J, Hébert MJ, Perreault CBlood 2011-02-03;117(5):1734-44.

A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault PMol. Cell Proteomics 2011-02-01;10(2):M110.004796.

Mechanistic principles of RAF kinase signaling.Udell CM, Rajakulendran T, Sicheri F, Therrien MCell. Mol. Life Sci. 2011-02-01;68(4):553-65.

Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JDCirc. Res. 2011-01-21;108(2):176-83.

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hébert J, Sauvageau GBlood 2011-01-13;117(2):e27-38.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PPJ. Biol. Chem. 2011-01-07;286(1):567-77.

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.Stefan E, Malleshaiah MK, Breton B, Ear PH, Bachmann V, Beyermann M, Bouvier M, Michnick SWNat Commun 2011-01-01;2:598.

Targeting the oncogene eIF4E in cancer: From the bench to clinical trials.Borden KLClin Invest Med 2011-01-01;34(6):E315.

Affinity purification of protein complexes in C. elegans.Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR, Oegema K, Desai AMethods Cell Biol. 2011-01-01;106:289-322.

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault CMol. Syst. Biol. 2011-01-01;7:533.

Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast.Wilhelm BT, Marguerat S, Aligianni S, Codlin S, Watt S, Bähler JGenome Biol. 2011-01-01;12(8):R82.

Phosphorylation network rewiring by gene duplication.Freschi L, Courcelles M, Thibault P, Michnick SW, Landry CRMol. Syst. Biol. 2011-01-01;7:504.

Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.Heinonen KM, Vanegas JR, Lew D, Krosl J, Perreault CPLoS ONE 2011-01-01;6(4):e19279.

The exon junction complex: a splicing factor for long intron containing transcripts?Ashton-Beaucage D, Therrien MFly (Austin) 2011-01-01;5(3):224-33.

Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.FitzGerald J, Moureau S, Drogaris P, O'Connell E, Abshiru N, Verreault A, Thibault P, Grenon M, Lowndes NFPLoS ONE 2011-01-01;6(2):e14714.

Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells.Volpato JP, Mayotte N, Fossati E, Guerrero V, Sauvageau G, Pelletier JNJ. Mol. Recognit. 2011-01-01;24(2):188-98.

Paving the way for targeting RSK in cancer.Romeo Y, Roux PPExpert Opin. Ther. Targets 2011-01-01;15(1):5-9.

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