Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Cytokinesis: cells go back and forth about division.Dorn JF, Maddox ASCurr. Biol. 2011-10-25;21(20):R848-50.

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Ratsima H, Ladouceur AM, Pascariu M, Sauvé V, Salloum Z, Maddox PS, D'Amours DProc. Natl. Acad. Sci. U.S.A. 2011-10-25;108(43):E914-23.

Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.Capalbo L, D'Avino PP, Archambault V, Glover DMProc. Natl. Acad. Sci. U.S.A. 2011-10-18;108(42):17343-8.

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, Payre F, Carreno SJ. Cell Biol. 2011-10-03;195(1):99-112.

Genome-wide Fitness Profiles Reveal a Requirement for Autophagy During Yeast Fermentation.Piggott N, Cook MA, Tyers M, Measday VG3 (Bethesda) 2011-10-01;1(5):353-67.

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JSSci Signal 2011-09-20;4(191):ra60.

Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.Rafei M, Hardy MP, Williams P, Vanegas JR, Forner KA, Dulude G, Labrecque N, Galipeau J, Perreault CJ. Immunol. 2011-09-15;187(6):3133-44.

Next-generation leukemia immunotherapy.Vincent K, Roy DC, Perreault CBlood 2011-09-15;118(11):2951-9.

NMR structure of a 4 x 4 nucleotide RNA internal loop from an R2 retrotransposon: identification of a three purine-purine sheared pair motif and comparison to MC-SYM predictions.Lerman YV, Kennedy SD, Shankar N, Parisien M, Major F, Turner DHRNA 2011-09-01;17(9):1664-77.

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.Huber A, French SL, Tekotte H, Yerlikaya S, Stahl M, Perepelkina MP, Tyers M, Rougemont J, Beyer AL, Loewith REMBO J. 2011-08-03;30(15):3052-64.

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