Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Cancer: A drug-resistant duo.Lavoie H, Therrien MNature 2011-12-15;480(7377):329-30.

DNA-binding properties of Smc6, a core component of the Smc5-6 DNA repair complex.Roy MA, D'Amours DBiochem. Biophys. Res. Commun. 2011-12-09;416(1-2):80-5.

A prospective pilot study investigating the musculoskeletal pain in postmenopausal breast cancer patients receiving aromatase inhibitor therapy.Robidoux A, Rich E, Bureau NJ, Mader S, Laperrière D, Bail M, Tremblay N, Patenaude M, Turgeon JCurr Oncol 2011-12-01;18(6):285-94.

PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JPDNA Repair (Amst.) 2011-11-10;10(11):1164-73.

Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.Heinonen KM, Vanegas JR, Brochu S, Shan J, Vainio SJ, Perreault CBlood 2011-11-10;118(19):5163-73.

Structural messenger RNA contains cytokeratin polymerization and depolymerization signals.Kloc M, Dallaire P, Reunov A, Major FCell Tissue Res. 2011-11-01;346(2):209-22.

HCaRG accelerates tubular repair after ischemic kidney injury.Matsuda H, Lavoie JL, Gaboury L, Hamet P, Tremblay JJ. Am. Soc. Nephrol. 2011-11-01;22(11):2077-89.

Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production.Chatel-Chaix L, Melançon P, Racine MÈ, Baril M, Lamarre DJ. Virol. 2011-11-01;85(21):11022-37.

Incidence and prognostic value of eosinophilia in chronic graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation.Ahmad I, Labbé AC, Chagnon M, Busque L, Cohen S, Kiss T, Lachance S, Roy DC, Sauvageau G, Roy JBiol. Blood Marrow Transplant. 2011-11-01;17(11):1673-8.

C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.Bisaillon R, Wilhelm BT, Krosl J, Sauvageau GBlood 2011-10-27;118(17):4682-9.

Cytokinesis: cells go back and forth about division.Dorn JF, Maddox ASCurr. Biol. 2011-10-25;21(20):R848-50.

Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.Ratsima H, Ladouceur AM, Pascariu M, Sauvé V, Salloum Z, Maddox PS, D'Amours DProc. Natl. Acad. Sci. U.S.A. 2011-10-25;108(43):E914-23.

Rab5 GTPase controls chromosome alignment through Lamin disassembly and relocation of the NuMA-like protein Mud to the poles during mitosis.Capalbo L, D'Avino PP, Archambault V, Glover DMProc. Natl. Acad. Sci. U.S.A. 2011-10-18;108(42):17343-8.

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, Payre F, Carreno SJ. Cell Biol. 2011-10-03;195(1):99-112.

Genome-wide Fitness Profiles Reveal a Requirement for Autophagy During Yeast Fermentation.Piggott N, Cook MA, Tyers M, Measday VG3 (Bethesda) 2011-10-01;1(5):353-67.

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JSSci Signal 2011-09-20;4(191):ra60.

Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.Rafei M, Hardy MP, Williams P, Vanegas JR, Forner KA, Dulude G, Labrecque N, Galipeau J, Perreault CJ. Immunol. 2011-09-15;187(6):3133-44.

Next-generation leukemia immunotherapy.Vincent K, Roy DC, Perreault CBlood 2011-09-15;118(11):2951-9.

NMR structure of a 4 x 4 nucleotide RNA internal loop from an R2 retrotransposon: identification of a three purine-purine sheared pair motif and comparison to MC-SYM predictions.Lerman YV, Kennedy SD, Shankar N, Parisien M, Major F, Turner DHRNA 2011-09-01;17(9):1664-77.

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.Huber A, French SL, Tekotte H, Yerlikaya S, Stahl M, Perepelkina MP, Tyers M, Rougemont J, Beyer AL, Loewith REMBO J. 2011-08-03;30(15):3052-64.

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.Stallaert W, Christopoulos A, Bouvier MExpert Opin Drug Discov 2011-08-01;6(8):811-25.

PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos.Wang P, Pinson X, Archambault VPLoS Genet. 2011-08-01;7(8):e1002227.

Microcalcifications around a collagen-based breast biopsy marker: complication of biopsy with a percutaneous marking system.Trop I, David J, El Khoury M, Gautier N, Gaboury L, Lalonde LAJR Am J Roentgenol 2011-08-01;197(2):W353-7.

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MDJ. Biol. Chem. 2011-07-15;286(28):24638-48.

PSICQUIC and PSISCORE: accessing and scoring molecular interactions.Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob HNat. Methods 2011-07-01;8(7):528-9.

ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses.Courcelles M, Lemieux S, Voisin L, Meloche S, Thibault PProteomics 2011-07-01;11(13):2654-71.

Roles for MSI2 and PROX1 in hematopoietic stem cell activity.Hope KJ, Sauvageau GCurr. Opin. Hematol. 2011-07-01;18(4):203-7.

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens.Kraljacic BC, Arguello M, Amri A, Cormack G, Borden KLeukemia 2011-07-01;25(7):1197-200.

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.Hassan S, Buchanan M, Jahan K, Aguilar-Mahecha A, Gaboury L, Muller WJ, Alsawafi Y, Mourskaia AA, Siegel PM, Salvucci O, Basik MInt. J. Cancer 2011-07-01;129(1):225-32.

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri FCell 2011-06-24;145(7):1075-87.

The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis.Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carréno SCurr. Biol. 2011-06-21;21(12):1074-9.

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GDNat. Chem. Biol. 2011-06-01;7(6):348-50.

Cell size: chromosomes get slapped by a midzone ruler.Ladouceur AM, Ranjan R, Maddox PSCurr. Biol. 2011-05-24;21(10):R388-90.

G protein-coupled receptor modulation with pepducins: moving closer to the clinic.Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SWAnn. N. Y. Acad. Sci. 2011-05-01;1226:34-49.

Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.Pettersson F, Yau C, Dobocan MC, Culjkovic-Kraljacic B, Retrouvay H, Puckett R, Flores LM, Krop IE, Rousseau C, Cocolakis E, Borden KL, Benz CC, Miller WHClin. Cancer Res. 2011-05-01;17(9):2874-84.

Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Schubert S, Barker KS, Znaidi S, Schneider S, Dierolf F, Dunkel N, Aïd M, Boucher G, Rogers PD, Raymond M, Morschhäuser JAntimicrob. Agents Chemother. 2011-05-01;55(5):2212-23.

Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation.Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel SBiomaterials 2011-05-01;32(13):3481-6.

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema KJ. Cell Biol. 2011-04-04;193(1):155-69.

An anticlastogenic function for the Polycomb Group gene Bmi1.Chagraoui J, Hébert J, Girard S, Sauvageau GProc. Natl. Acad. Sci. U.S.A. 2011-03-29;108(13):5284-9.

Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LEJ. Biol. Chem. 2011-03-18;286(11):9360-72.

H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJPLoS Genet. 2011-03-01;7(3):e1001354.

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Cargnello M, Roux PPMicrobiol. Mol. Biol. Rev. 2011-03-01;75(1):50-83.

Evolution of the repertoire of nuclear receptor binding sites in genomes.Cotnoir-White D, Laperrière D, Mader SMol. Cell. Endocrinol. 2011-03-01;334(1-2):76-82.

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche SJ. Biol. Chem. 2011-02-25;286(8):6470-8.

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Chartier NT, Salazar Ospina DP, Benkemoun L, Mayer M, Grill SW, Maddox AS, Labbé JCCurr. Biol. 2011-02-22;21(4):259-69.

Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex.Roy MA, Siddiqui N, D'Amours DCell Cycle 2011-02-15;10(4):690-700.

Fitness without exhaustion.Perreault CBlood 2011-02-10;117(6):1776.

Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.Tang Y, Holbert MA, Delgoshaie N, Wurtele H, Guillemette B, Meeth K, Yuan H, Drogaris P, Lee EH, Durette C, Thibault P, Verreault A, Cole PA, Marmorstein RStructure 2011-02-09;19(2):221-31.

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.Giroux M, Delisle JS, Gauthier SD, Heinonen KM, Hinsinger J, Houde B, Gaboury L, Brochu S, Wu J, Hébert MJ, Perreault CBlood 2011-02-03;117(5):1734-44.

A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault PMol. Cell Proteomics 2011-02-01;10(2):M110.004796.

Mechanistic principles of RAF kinase signaling.Udell CM, Rajakulendran T, Sicheri F, Therrien MCell. Mol. Life Sci. 2011-02-01;68(4):553-65.

Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JDCirc. Res. 2011-01-21;108(2):176-83.

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hébert J, Sauvageau GBlood 2011-01-13;117(2):e27-38.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PPJ. Biol. Chem. 2011-01-07;286(1):567-77.

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.Stefan E, Malleshaiah MK, Breton B, Ear PH, Bachmann V, Beyermann M, Bouvier M, Michnick SWNat Commun 2011-01-01;2:598.

Targeting the oncogene eIF4E in cancer: From the bench to clinical trials.Borden KLClin Invest Med 2011-01-01;34(6):E315.

Affinity purification of protein complexes in C. elegans.Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR, Oegema K, Desai AMethods Cell Biol. 2011-01-01;106:289-322.

The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoullé A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault CMol. Syst. Biol. 2011-01-01;7:533.

Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast.Wilhelm BT, Marguerat S, Aligianni S, Codlin S, Watt S, Bähler JGenome Biol. 2011-01-01;12(8):R82.

Phosphorylation network rewiring by gene duplication.Freschi L, Courcelles M, Thibault P, Michnick SW, Landry CRMol. Syst. Biol. 2011-01-01;7:504.

Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.Heinonen KM, Vanegas JR, Lew D, Krosl J, Perreault CPLoS ONE 2011-01-01;6(4):e19279.

The exon junction complex: a splicing factor for long intron containing transcripts?Ashton-Beaucage D, Therrien MFly (Austin) 2011-01-01;5(3):224-33.

Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.FitzGerald J, Moureau S, Drogaris P, O'Connell E, Abshiru N, Verreault A, Thibault P, Grenon M, Lowndes NFPLoS ONE 2011-01-01;6(2):e14714.

Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells.Volpato JP, Mayotte N, Fossati E, Guerrero V, Sauvageau G, Pelletier JNJ. Mol. Recognit. 2011-01-01;24(2):188-98.

Paving the way for targeting RSK in cancer.Romeo Y, Roux PPExpert Opin. Ther. Targets 2011-01-01;15(1):5-9.

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