Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?Borden KL, Culjkovic-Kraljacic BLeuk. Lymphoma 2010-10-01;51(10):1805-15.

Medicine. The blood stem cell Holy Grail?Sauvageau G, Humphries RKScience 2010-09-10;329(5997):1291-2.

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.Krosl J, Mamo A, Chagraoui J, Wilhelm BT, Girard S, Louis I, Lessard J, Perreault C, Sauvageau GBlood 2010-09-09;116(10):1678-84.

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Sauvageau M, Sauvageau GCell Stem Cell 2010-09-03;7(3):299-313.

Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I Verteuil D, Muratore-Schroeder TL, Granados DP, Fortier MH, Hardy MP, Bramoullé A, Caron E, Vincent K, Mader S, Lemieux S, Thibault P, Perreault CMol. Cell Proteomics 2010-09-01;9(9):2034-47.

Three-step model for condensin activation during mitotic chromosome condensation.Bazile F, St-Pierre J, D'Amours DCell Cycle 2010-08-15;9(16):3243-55.

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway.Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SAJ. Biol. Chem. 2010-08-13;285(33):25624-36.

RNA structure determination using SAXS data.Yang S, Parisien M, Major F, Roux BJ Phys Chem B 2010-08-12;114(31):10039-48.

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg NProc. Natl. Acad. Sci. U.S.A. 2010-08-10;107(32):14134-9.

Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel.Chatel-Chaix L, Baril M, Lamarre DViruses 2010-08-01;2(8):1752-65.

T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.Giroux M, Delisle JS, O'Brien A, Hébert MJ, Perreault CJ. Immunol. 2010-08-01;185(3):1568-76.

Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis.Solinski HJ, Boekhoff I, Bouvier M, Gudermann T, Breit AMol. Pharmacol. 2010-08-01;78(2):249-59.

Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer.Audet M, Lagacé M, Silversides DW, Bouvier MFASEB J. 2010-08-01;24(8):2829-38.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola MBioinformatics 2010-07-15;26(14):1804-5.

An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau GCell Stem Cell 2010-07-02;7(1):101-13.

Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai.Oner SS, Maher EM, Breton B, Bouvier M, Blumer JBJ. Biol. Chem. 2010-07-02;285(27):20588-94.

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond MNat. Med. 2010-07-01;16(7):774-80.

Designing small multiple-target artificial RNAs.De Guire V, Caron M, Scott N, Ménard C, Gaumont-Leclerc MF, Chartrand P, Major F, Ferbeyre GNucleic Acids Res. 2010-07-01;38(13):e140.

Clinical and biochemical features of seven adult adrenal ganglioneuromas.Rondeau G, Nolet S, Latour M, Braschi S, Gaboury L, Lacroix A, Panzini B, Arjane P, Cohade C, Bourdeau IJ. Clin. Endocrinol. Metab. 2010-07-01;95(7):3118-25.

Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation during Drosophila development.Roch F, Polesello C, Roubinet C, Martin M, Roy C, Valenti P, Carreno S, Mangeat P, Payre FJ. Cell. Sci. 2010-06-15;123(Pt 12):2058-67.

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang TGenes Dev. 2010-06-01;24(11):1093-105.

Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells.Demers M, Rose AA, Grosset AA, Biron-Pain K, Gaboury L, Siegel PM, St-Pierre YAm. J. Pathol. 2010-06-01;176(6):3023-31.

Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.Voisin L, Saba-El-Leil MK, Julien C, Frémin C, Meloche SMol. Cell. Biol. 2010-06-01;30(12):2918-32.

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.Tanguay PL, Rodier G, Meloche SBiochem. J. 2010-05-15;428(1):103-11.

Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JGCell 2010-05-14;141(4):632-44.

[It takes two RAFs to tango].Lavoie H, Therrien MMed Sci (Paris) 2010-05-01;26(5):459-60.

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal SM, von Zastrow M, Bouvier MMol. Pharmacol. 2010-05-01;77(5):836-45.

Understanding the role of asymmetric cell division in cancer using C. elegans.Hyenne V, Chartier NT, Labbé JCDev. Dyn. 2010-05-01;239(5):1378-87.

Late acute renal failure due to bilateral kidney infiltration by ALL as single manifestation of relapse after allogeneic transplantation.Detrait M, Meunier C, Roy DC, Kiss T, Lachance S, Cohen S, Busque L, Sauvageau G, Roy JBone Marrow Transplant. 2010-05-01;45(5):953-4.

High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.Sartelet H, Ohta S, Barrette S, Rougemont AL, Brevet M, Regairaz M, Harvey I, Bernard C, Fabre M, Gaboury L, Oligny LL, Bosq J, Valteau-Couanet D, Vassal GHistopathology 2010-04-01;56(5):607-16.

Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer.Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M, Gaboury L, Siegel PMClin. Cancer Res. 2010-04-01;16(7):2147-56.

Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.Volpon L, Osborne MJ, Capul AA, de la Torre JC, Borden KLProc. Natl. Acad. Sci. U.S.A. 2010-03-23;107(12):5441-6.

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein.García CC, Topisirovic I, Djavani M, Borden KL, Damonte EB, Salvato MSBiochem. Biophys. Res. Commun. 2010-03-19;393(4):625-30.

Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection.Rodrigue-Gervais IG, Rigsby H, Jouan L, Sauvé D, Sékaly RP, Willems B, Lamarre DJ. Immunol. 2010-03-15;184(6):3134-44.

Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JLJ. Biol. Chem. 2010-03-05;285(10):7805-17.

Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.Hoang TSci Transl Med 2010-03-03;2(21):21ps10.

[Mechanisms of asymmetric cell division: from model organisms to tumorigenesis]Chartier NT, Hyenne V, Labbé JCMed Sci (Paris) 2010-03-01;26(3):251-7.

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche SCell Cycle 2010-03-01;9(5):975-9.

Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.Epp E, Walther A, Lépine G, Leon Z, Mullick A, Raymond M, Wendland J, Whiteway MMol. Microbiol. 2010-03-01;75(5):1182-98.

Multimerization of Staufen1 in live cells.Martel C, Dugré-Brisson S, Boulay K, Breton B, Lapointe G, Armando S, Trépanier V, Duchaîne T, Bouvier M, Desgroseillers LRNA 2010-03-01;16(3):585-97.

Anillin.Zhang L, Maddox ASCurr. Biol. 2010-02-23;20(4):R135-6.

Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.Zakaria C, Kassahun H, Yang X, Labbé JC, Nilsen H, Ramotar DDNA Repair (Amst.) 2010-02-04;9(2):169-76.

Differential requirements for STRAD in LKB1-dependent functions in C. elegans.Narbonne P, Hyenne V, Li S, Labbé JC, Roy RDevelopment 2010-02-01;137(4):661-70.

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre DJ. Hepatol. 2010-02-01;52(2):167-75.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.Julien LA, Carriere A, Moreau J, Roux PPMol. Cell. Biol. 2010-02-01;30(4):908-21.

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang TBlood 2010-01-28;115(4):792-803.

Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.Wang TT, Dabbas B, Laperriere D, Bitton AJ, Soualhine H, Tavera-Mendoza LE, Dionne S, Servant MJ, Bitton A, Seidman EG, Mader S, Behr MA, White JHJ. Biol. Chem. 2010-01-22;285(4):2227-31.

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau GPLoS Genet. 2010-01-01;6(12):e1001241.

Subcellular phosphoproteomics.Trost M, Bridon G, Desjardins M, Thibault PMass Spectrom Rev 2010-01-01;29(6):962-90.

LRCH proteins: a novel family of cytoskeletal regulators.Foussard H, Ferrer P, Valenti P, Polesello C, Carreno S, Payre FPLoS ONE 2010-01-01;5(8):e12257.

Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia.Tremblay CS, Hoang T, Hoang TProg Mol Biol Transl Sci 2010-01-01;92:121-56.

The origin and role of MHC class I-associated self-peptides.Perreault CProg Mol Biol Transl Sci 2010-01-01;92:41-60.

Questions arising from "genome duplication and T cell immunity".Perreault CProg Mol Biol Transl Sci 2010-01-01;92:37; discussion 38-9.

RKB: a Semantic Web knowledge base for RNA.Cruz-Toledo J, Dumontier M, Parisien M, Major FJ Biomed Semantics 2010-01-01;1 Suppl 1:S2.

Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.Soucy-Faulkner A, Mukawera E, Fink K, Martel A, Jouan L, Nzengue Y, Lamarre D, Vande Velde C, Grandvaux NPLoS Pathog. 2010-01-01;6(6):e1000930.

Free centrosomes: where do they all come from?Archambault V, Pinson XFly (Austin) 2010-01-01;4(2):172-7.

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.Frémin C, Meloche SJ Hematol Oncol 2010-01-01;3:8.

[Hopes and challenges in biomedical research].Bouvier M, Chneiweiss HMed Sci (Paris) 2010-01-01;26(1):3-4.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DCJ. Biol. Chem. 2010-01-01;285(1):80-94.

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