Publications
Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.
Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration.Proc. Natl. Acad. Sci. U.S.A. 2010-12-28;107(52):22558-63.
Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes.J. Cell Biol. 2010-12-27;191(7):1351-65.
A comprehensive map of the mTOR signaling network.Mol. Syst. Biol. 2010-12-21;6:453.
When enough is enough: detrimental effects of excess histones.Cell Cycle 2010-12-15;9(24):4783.
Multiplexing of multicolor bioluminescence resonance energy transfer.Biophys. J. 2010-12-15;99(12):4037-46.
Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.Blood 2010-12-02;116(23):4859-69.
[The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network].Med Sci (Paris) 2010-12-01;26(12):1067-73.
[mTOR, the mammalian target of rapamycin].Med Sci (Paris) 2010-12-01;26(12):1056-60.
A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A.Nat. Cell Biol. 2010-12-01;12(12):1186-93.
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.EMBO J. 2010-12-01;29(23):3939-51.
Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.Mol. Cell. Biol. 2010-12-01;30(24):5752-63.
RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles.Nucleic Acids Res. 2010-12-01;38(22):8149-63.
Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity.J. Pharmacol. Exp. Ther. 2010-12-01;335(3):520-32.
The myriad roles of Anillin during cytokinesis.Semin. Cell Dev. Biol. 2010-12-01;21(9):881-91.
Combining resonance energy transfer methods reveals a complex between the alpha2A-adrenergic receptor, Galphai1beta1gamma2, and GRK2.FASEB J. 2010-12-01;24(12):4733-43.
Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.Fam. Cancer 2010-12-01;9(4):507-17.
Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.J. Cell Biol. 2010-11-29;191(5):953-66.
Cell biology. Puzzled by PML.Science 2010-11-26;330(6008):1183-4.
Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans.Curr. Biol. 2010-11-23;20(22):2046-51.
An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.Curr. Biol. 2010-11-23;20(22):2021-7.
Chromatin regulatory mechanisms in pluripotency.Annu. Rev. Cell Dev. Biol. 2010-11-10;26:503-32.
Caterpillar- and salivary-specific modification of plant proteins.J. Proteome Res. 2010-11-05;9(11):5887-95.
The T-ALL paradox in cancer.Nat. Med. 2010-11-01;16(11):1185-6.
HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells.Exp. Hematol. 2010-11-01;38(11):1074-1086.e1-5.
Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.J. Biol. Chem. 2010-10-29;285(44):33949-58.
Molecular characterization of the evolution of phagosomes.Mol. Syst. Biol. 2010-10-19;6:423.
The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.Cell 2010-10-15;143(2):251-62.
Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC.J. Biol. Chem. 2010-10-08;285(41):31233-42.
A two-locus system controls susceptibility to colitis-associated colon cancer in mice.Oncotarget 2010-10-01;1(6):436-46.
[Hepatitis C virus subverts pattern recognition receptors-mediated control of adaptative immunity orchestrated by dendritic cells].Med Sci (Paris) 2010-10-01;26(10):869-74.
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?Leuk. Lymphoma 2010-10-01;51(10):1805-15.
Medicine. The blood stem cell Holy Grail?Science 2010-09-10;329(5997):1291-2.
A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.Blood 2010-09-09;116(10):1678-84.
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.Cell Stem Cell 2010-09-03;7(3):299-313.
Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules.Mol. Cell Proteomics 2010-09-01;9(9):2034-47.
Three-step model for condensin activation during mitotic chromosome condensation.Cell Cycle 2010-08-15;9(16):3243-55.
A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway.J. Biol. Chem. 2010-08-13;285(33):25624-36.
RNA structure determination using SAXS data.J Phys Chem B 2010-08-12;114(31):10039-48.
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Proc. Natl. Acad. Sci. U.S.A. 2010-08-10;107(32):14134-9.
Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel.Viruses 2010-08-01;2(8):1752-65.
T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.J. Immunol. 2010-08-01;185(3):1568-76.
Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis.Mol. Pharmacol. 2010-08-01;78(2):249-59.
Protein-protein interactions monitored in cells from transgenic mice using bioluminescence resonance energy transfer.FASEB J. 2010-08-01;24(8):2829-38.
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.Bioinformatics 2010-07-15;26(14):1804-5.
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.Cell Stem Cell 2010-07-02;7(1):101-13.
Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai.J. Biol. Chem. 2010-07-02;285(27):20588-94.
Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.Nat. Med. 2010-07-01;16(7):774-80.
Designing small multiple-target artificial RNAs.Nucleic Acids Res. 2010-07-01;38(13):e140.
Clinical and biochemical features of seven adult adrenal ganglioneuromas.J. Clin. Endocrinol. Metab. 2010-07-01;95(7):3118-25.
Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation during Drosophila development.J. Cell. Sci. 2010-06-15;123(Pt 12):2058-67.
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Genes Dev. 2010-06-01;24(11):1093-105.
Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells.Am. J. Pathol. 2010-06-01;176(6):3023-31.
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation.Mol. Cell. Biol. 2010-06-01;30(12):2918-32.
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.Biochem. J. 2010-05-15;428(1):103-11.
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.Cell 2010-05-14;141(4):632-44.
[It takes two RAFs to tango].Med Sci (Paris) 2010-05-01;26(5):459-60.
Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments.Mol. Pharmacol. 2010-05-01;77(5):836-45.
Understanding the role of asymmetric cell division in cancer using C. elegans.Dev. Dyn. 2010-05-01;239(5):1378-87.
Late acute renal failure due to bilateral kidney infiltration by ALL as single manifestation of relapse after allogeneic transplantation.Bone Marrow Transplant. 2010-05-01;45(5):953-4.
High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.Histopathology 2010-04-01;56(5):607-16.
Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer.Clin. Cancer Res. 2010-04-01;16(7):2147-56.
Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.Proc. Natl. Acad. Sci. U.S.A. 2010-03-23;107(12):5441-6.
An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein.Biochem. Biophys. Res. Commun. 2010-03-19;393(4):625-30.
Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection.J. Immunol. 2010-03-15;184(6):3134-44.
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.J. Biol. Chem. 2010-03-05;285(10):7805-17.
Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia.Sci Transl Med 2010-03-03;2(21):21ps10.
[Mechanisms of asymmetric cell division: from model organisms to tumorigenesis]Med Sci (Paris) 2010-03-01;26(3):251-7.
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.Cell Cycle 2010-03-01;9(5):975-9.
Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.Mol. Microbiol. 2010-03-01;75(5):1182-98.
Multimerization of Staufen1 in live cells.RNA 2010-03-01;16(3):585-97.
Anillin.Curr. Biol. 2010-02-23;20(4):R135-6.
Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.DNA Repair (Amst.) 2010-02-04;9(2):169-76.
Differential requirements for STRAD in LKB1-dependent functions in C. elegans.Development 2010-02-01;137(4):661-70.
Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.J. Hepatol. 2010-02-01;52(2):167-75.
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.Mol. Cell. Biol. 2010-02-01;30(4):908-21.
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.Blood 2010-01-28;115(4):792-803.
Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.J. Biol. Chem. 2010-01-22;285(4):2227-31.
Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.PLoS Genet. 2010-01-01;6(12):e1001241.
Subcellular phosphoproteomics.Mass Spectrom Rev 2010-01-01;29(6):962-90.
LRCH proteins: a novel family of cytoskeletal regulators.PLoS ONE 2010-01-01;5(8):e12257.
Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia.Prog Mol Biol Transl Sci 2010-01-01;92:121-56.
The origin and role of MHC class I-associated self-peptides.Prog Mol Biol Transl Sci 2010-01-01;92:41-60.
Questions arising from "genome duplication and T cell immunity".Prog Mol Biol Transl Sci 2010-01-01;92:37; discussion 38-9.
RKB: a Semantic Web knowledge base for RNA.J Biomed Semantics 2010-01-01;1 Suppl 1:S2.
Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.PLoS Pathog. 2010-01-01;6(6):e1000930.
Free centrosomes: where do they all come from?Fly (Austin) 2010-01-01;4(2):172-7.
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.J Hematol Oncol 2010-01-01;3:8.
[Hopes and challenges in biomedical research].Med Sci (Paris) 2010-01-01;26(1):3-4.
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.J. Biol. Chem. 2010-01-01;285(1):80-94.
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