Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function.Rolef Ben-Shahar T, Castillo AG, Osborne MJ, Borden KL, Kornblatt J, Verreault AMol. Cell. Biol. 2009-12-01;29(24):6353-65.

Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.Sima A, Parisotto M, Mader S, Bhat PVBiochim. Biophys. Acta 2009-12-01;1790(12):1660-4.

A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Ploski JE, Topisirovic I, Park KW, Borden KL, Radu AMol. Cell. Biochem. 2009-12-01;332(1-2):173-81.

NanoLC-MS/MS analyses of urinary desmosine, hydroxylysylpyridinoline and lysylpyridinoline as biomarkers for chronic graft-versus-host disease.Boutin M, Ahmad I, Jauhiainen M, Lachapelle N, Rondeau C, Roy J, Thibault PAnal. Chem. 2009-11-15;81(22):9454-61.

Recognition and coupling of A-to-I edited sites are determined by the tertiary structure of the RNA.Ensterö M, Daniel C, Wahlstedt H, Major F, Ohman MNucleic Acids Res. 2009-11-01;37(20):6916-26.

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Spilker AC, Rabilotta A, Zbinden C, Labbé JC, Gotta MGenetics 2009-11-01;183(3):965-77.

Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression.Palijan A, Fernandes I, Verway M, Kourelis M, Bastien Y, Tavera-Mendoza LE, Sacheli A, Bourdeau V, Mader S, White JHJ. Biol. Chem. 2009-10-30;284(44):30275-87.

Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR.Palijan A, Fernandes I, Bastien Y, Tang L, Verway M, Kourelis M, Tavera-Mendoza LE, Li Z, Bourdeau V, Mader S, Yang XJ, White JHJ. Biol. Chem. 2009-10-30;284(44):30264-74.

Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus.Bockenhauer D, Carpentier E, Rochdi D, Van't Hoff W, Breton B, Bernier V, Bouvier M, Bichet DGNephron Physiol 2009-10-08;114(1):p1-p10.

New metrics for comparing and assessing discrepancies between RNA 3D structures and models.Parisien M, Cruz JA, Westhof E, Major FRNA 2009-10-01;15(10):1875-85.

VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist.Rihakova L, Quiniou C, Hamdan FF, Kaul R, Brault S, Hou X, Lahaie I, Sapieha P, Hamel D, Shao Z, Gobeil F, Hardy P, Joyal JS, Nedev H, Duhamel F, Beauregard K, Heveker N, Saragovi HU, Guillon G, Bouvier M, Lubell WD, Chemtob SAm. J. Physiol. Regul. Integr. Comp. Physiol. 2009-10-01;297(4):R1009-18.

Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development.Blagden SP, Gatt MK, Archambault V, Lada K, Ichihara K, Lilley KS, Inoue YH, Glover DMDev. Biol. 2009-10-01;334(1):186-97.

Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MDMol. Pharmacol. 2009-10-01;76(4):791-801.

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.Leduc M, Breton B, Galés C, Le Gouill C, Bouvier M, Chemtob S, Heveker NJ. Pharmacol. Exp. Ther. 2009-10-01;331(1):297-307.

Implementation of a Canadian external quality assurance program for breast cancer biomarkers: an initiative of Canadian Quality Control in immunohistochemistry (cIQc) and Canadian Association of Pathologists (CAP) National Standards Committee/Immunohistochemistry.Terry J, Torlakovic EE, Garratt J, Miller D, Köbel M, Cooper J, Bahzad S, Pilavdzic D, O'Malley F, O'Brien AE, SenGupta S, Alport E, Têtu B, Knight B, Pettigrew NM, Berendt R, Wolber R, Trotter MJ, Riddell RH, Gaboury L, Elms F, Magliocco A, Barnes P, Gown AM, Gilks CBAppl. Immunohistochem. Mol. Morphol. 2009-10-01;17(5):375-82.

Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.Klinger S, Turgeon B, Lévesque K, Wood GA, Aagaard-Tillery KM, Meloche SProc. Natl. Acad. Sci. U.S.A. 2009-09-29;106(39):16710-5.

A dimerization-dependent mechanism drives RAF catalytic activation.Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien MNature 2009-09-24;461(7263):542-5.

A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties.Rafei M, Hsieh J, Zehntner S, Li M, Forner K, Birman E, Boivin MN, Young YK, Perreault C, Galipeau JNat. Med. 2009-09-01;15(9):1038-45.

Control of p53 multimerization by Ubc13 is JNK-regulated.Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZAProc. Natl. Acad. Sci. U.S.A. 2009-08-04;106(31):12676-81.

Enhanced protein detection using a trapping mode on a hybrid quadrupole linear ion trap (Q-Trap).Drogaris P, Le Blanc JC, Fitzgerald JE, Lowndes NF, Verreault A, Thibault PAnal. Chem. 2009-08-01;81(15):6300-9.

Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality.Sabry W, Le Blanc R, Labbé AC, Sauvageau G, Couban S, Kiss T, Busque L, Cohen S, Lachance S, Roy DC, Roy JBiol. Blood Marrow Transplant. 2009-08-01;15(8):919-29.

Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones.Kobayashi H, Ogawa K, Yao R, Lichtarge O, Bouvier MTraffic 2009-08-01;10(8):1019-33.

Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods.d'Assignies G, Ruel M, Khiat A, Lepanto L, Chagnon M, Kauffmann C, Tang A, Gaboury L, Boulanger YEur Radiol 2009-08-01;19(8):2033-40.

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.Assouline S, Culjkovic B, Cocolakis E, Rousseau C, Beslu N, Amri A, Caplan S, Leber B, Roy DC, Miller WH, Borden KLBlood 2009-07-09;114(2):257-60.

Tissue targeting in cancer: eIF4E's tale.Borden KLClin. Cancer Res. 2009-07-01;15(13):4254-5.

The influence of tumor-host interactions in the stromal cell-derived factor-1/CXCR4 ligand/receptor axis in determining metastatic risk in breast cancer.Hassan S, Ferrario C, Saragovi U, Quenneville L, Gaboury L, Baccarelli A, Salvucci O, Basik MAm. J. Pathol. 2009-07-01;175(1):66-73.

Enhanced sensitivity in proteomics experiments using FAIMS coupled with a hybrid linear ion trap/Orbitrap mass spectrometer.Saba J, Bonneil E, Pomiès C, Eng K, Thibault PJ. Proteome Res. 2009-07-01;8(7):3355-66.

Primary cultures of human hepatocytes isolated from hepatitis C virus-infected cirrhotic livers as a model to study hepatitis C infection.Raymond VA, Selliah S, Ethier C, Houle R, Jouan L, Maniere T, Lamarre D, Willems B, Bilodeau MLiver Int. 2009-07-01;29(6):942-9.

Diphyllobothriasis, a rare cause of profuse diarrhea following autologous transplantation.Detrait M, Poirier L, Roy DC, Kiss T, Busque L, Cohen S, Lachance S, Sauvageau G, Roy JBone Marrow Transplant. 2009-07-01;44(2):131-2.

Histone acetylation floods the human cell cycle and DNA damage response.Delgoshaie N, Wurtele H, Verreault ACell Cycle 2009-06-15;8(12):1820.

Identification of the Candida albicans Cap1p regulon.Znaidi S, Barker KS, Weber S, Alarco AM, Liu TT, Boucher G, Rogers PD, Raymond MEukaryotic Cell 2009-06-01;8(6):806-20.

NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells.Gionet N, Jansson D, Mader S, Pratt MAJ. Cell. Biochem. 2009-06-01;107(3):448-59.

An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures.Csaszar E, Gavigan G, Ungrin M, Thérien C, Dubé P, Féthière J, Sauvageau G, Roy DC, Zandstra PWBiotechnol. Bioeng. 2009-06-01;103(2):402-12.

Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity.St-Pierre J, Douziech M, Bazile F, Pascariu M, Bonneil E, Sauvé V, Ratsima H, D'Amours DMol. Cell 2009-05-14;34(4):416-26.

Effects of angiotensin-converting enzyme inhibitor versus valsartan on cellular signaling events in heart transplant.White M, Ross H, Levesque S, Whittom L, Pelletier GB, Racine N, Meloche S, Voisin LAnn Pharmacother 2009-05-01;43(5):831-9.

Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.Trunk K, Gendron P, Nantel A, Lemieux S, Roemer T, Raymond MEukaryotic Cell 2009-05-01;8(5):756-67.

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.Topisirovic I, Siddiqui N, Lapointe VL, Trost M, Thibault P, Bangeranye C, Piñol-Roma S, Borden KLEMBO J. 2009-04-22;28(8):1087-98.

Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors.Pardin C, Roy I, Chica RA, Bonneil E, Thibault P, Lubell WD, Pelletier JN, Keillor JWBiochemistry 2009-04-21;48(15):3346-53.

A functional screen to identify novel effectors of hematopoietic stem cell activity.Deneault E, Cellot S, Faubert A, Laverdure JP, Fréchette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau GCell 2009-04-17;137(2):369-79.

Polo-like kinases: conservation and divergence in their functions and regulation.Archambault V, Glover DMNat. Rev. Mol. Cell Biol. 2009-04-01;10(4):265-75.

The eukaryotic translation initiation factor 4E (eIF4E) and HuR RNA operons collaboratively regulate the expression of survival and proliferative genes.Topisirovic I, Siddiqui N, Borden KLCell Cycle 2009-04-01;8(7):960-1.

Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.Tsao S, Rahkhoodaee F, Raymond MAntimicrob. Agents Chemother. 2009-04-01;53(4):1344-52.

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.Ho L, Ronan JL, Wu J, Staahl BT, Chen L, Kuo A, Lessard J, Nesvizhskii AI, Ranish J, Crabtree GRProc. Natl. Acad. Sci. U.S.A. 2009-03-31;106(13):5181-6.

Building a new conceptual framework for receptor heteromers.Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, Waldhoer M, Woods AS, Franco RNat. Chem. Biol. 2009-03-01;5(3):131-4.

High-sensitivity nanoLC-MS/MS analysis of urinary desmosine and isodesmosine.Boutin M, Berthelette C, Gervais FG, Scholand MB, Hoidal J, Leppert MF, Bateman KP, Thibault PAnal. Chem. 2009-03-01;81(5):1881-7.

Differential expression of SMAD3 transcripts is not regulated by cis-acting genetic elements but has a gender specificity.Busque L, Belisle C, Provost S, Giroux M, Perreault CGenes Immun. 2009-03-01;10(2):192-6.

Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KLMol. Cell. Biol. 2009-03-01;29(5):1152-62.

An enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture.Bendall SC, Hughes C, Campbell JL, Stewart MH, Pittock P, Liu S, Bonneil E, Thibault P, Bhatia M, Lajoie GAMol. Cell Proteomics 2009-03-01;8(3):421-32.

Artifactual sulfation of silver-stained proteins: implications for the assignment of phosphorylation and sulfation sites.Gharib M, Marcantonio M, Lehmann SG, Courcelles M, Meloche S, Verreault A, Thibault PMol. Cell Proteomics 2009-03-01;8(3):506-18.

[Histone acetylation and chromatin assembly]Wurtele H, Li Q, Zhou H, Zhang Z, Verreault AMed Sci (Paris) 2009-02-01;25(2):121-2.

Mucosal damage in the esophageal remnant after esophagectomy and gastric transposition.D'Journo XB, Martin J, Rakovich G, Brigand C, Gaboury L, Ferraro P, Duranceau AAnn. Surg. 2009-02-01;249(2):262-8.

The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila.Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien MGenetics 2009-02-01;181(2):567-79.

MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease.Baril M, Racine ME, Penin F, Lamarre DJ. Virol. 2009-02-01;83(3):1299-311.

Understanding the words of chromatin regulation.Wu JI, Lessard J, Crabtree GRCell 2009-01-23;136(2):200-6.

The phagosomal proteome in interferon-gamma-activated macrophages.Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault PImmunity 2009-01-16;30(1):143-54.

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.Culjkovic B, Borden KLJ Oncol 2009-01-01;2009:981679.

Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau GPLoS ONE 2009-01-01;4(10):e7500.

[Cdc14B/Skp2/p27 : a novel cancer axis of evil?]Coulombe P, Rodier G, Meloche SMed Sci (Paris) 2009-01-01;25(8-9):673-5.

Perspectives in PML: a unifying framework for PML function.Borden KL, Culjkovic BFront. Biosci. 2009-01-01;14:497-509.

ER stress affects processing of MHC class I-associated peptides.Granados DP, Tanguay PL, Hardy MP, Caron E, de Verteuil D, Meloche S, Perreault CBMC Immunol. 2009-01-01;10:10.

[Médecine/Sciences as time goes by].Chneiweiss H, Bouvier MMed Sci (Paris) 2009-01-01;25(1):3-4.

Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.Meunier MC, Baron C, Perreault CPLoS ONE 2009-01-01;4(1):e4116.

Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.Turgeon B, Meloche SPhysiol. Rev. 2009-01-01;89(1):1-26.

Molecular basis of TRAP-5'SL RNA interaction in the Bacillus subtilis trp operon transcription attenuation mechanism.McGraw AP, Mokdad A, Major F, Bevilacqua PC, Babitzke PRNA 2009-01-01;15(1):55-66.

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