Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction.Lécuyer E, Larivière S, Sincennes MC, Haman A, Lahlil R, Todorova M, Tremblay M, Wilkes BC, Hoang TJ. Biol. Chem. 2007-11-16;282(46):33649-58.

[New talk between receptor and trimeric G proteins: "an intertwined body dance"].Galés C, Bouvier MMed Sci (Paris) 2007-11-01;23(11):1031-4.

Isomer-specific retinoic acid biosynthesis in HeLa cells expressing recombinant class I aldehyde dehydrogenases.Brodeur H, Parisotto M, Chagnon S, Mader S, Bhat PVBiochim. Biophys. Acta 2007-11-01;1770(11):1548-56.

Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.Liu TT, Znaidi S, Barker KS, Xu L, Homayouni R, Saidane S, Morschhäuser J, Nantel A, Raymond M, Rogers PDEukaryotic Cell 2007-11-01;6(11):2122-38.

Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase.Castonguay R, Halim D, Morin M, Furtos A, Lherbet C, Bonneil E, Thibault P, Keillor JWBiochemistry 2007-10-30;46(43):12253-62.

Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1.Héroux M, Hogue M, Lemieux S, Bouvier MJ. Biol. Chem. 2007-10-26;282(43):31610-20.

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.Stefan E, Aquin S, Berger N, Landry CR, Nyfeler B, Bouvier M, Michnick SWProc. Natl. Acad. Sci. U.S.A. 2007-10-23;104(43):16916-21.

Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans.Couwenbergs C, Labbé JC, Goulding M, Marty T, Bowerman B, Gotta MJ. Cell Biol. 2007-10-08;179(1):15-22.

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.Hamdan FF, Rochdi MD, Breton B, Fessart D, Michaud DE, Charest PG, Laporte SA, Bouvier MJ. Biol. Chem. 2007-10-05;282(40):29089-100.

The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans.Znaidi S, De Deken X, Weber S, Rigby T, Nantel A, Raymond MMol. Microbiol. 2007-10-01;66(2):440-52.

High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantation.Labbé AC, Su SH, Laverdière M, Pépin J, Patiño C, Cohen S, Kiss T, Lachance S, Sauvageau G, Busque L, Roy DC, Roy JBiol. Blood Marrow Transplant. 2007-10-01;13(10):1192-200.

T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex.Giroux M, Yurchenko E, St-Pierre J, Piccirillo CA, Perreault CJ. Immunol. 2007-10-01;179(7):4492-502.

A comparative analysis of the triloops in all high-resolution RNA structures reveals sequence structure relationships.Lisi V, Major FRNA 2007-09-01;13(9):1537-45.

Ranking the factors that contribute to protein beta-sheet folding.Parisien M, Major FProteins 2007-09-01;68(4):824-9.

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JDProc. Natl. Acad. Sci. U.S.A. 2007-08-28;104(35):14074-9.

Updated recommendations from the Canadian National Consensus Meeting on HER2/neu testing in breast cancer.Hanna W, O'malley FP, Barnes P, Berendt R, Gaboury L, Magliocco A, Pettigrew N, Robertson S, Sengupta S, Têtu B, Thomson TCurr Oncol 2007-08-01;14(4):149-53.

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith ADevelopment 2007-08-01;134(16):2895-902.

The evasive nature of drug efficacy: implications for drug discovery.Galandrin S, Oligny-Longpré G, Bouvier MTrends Pharmacol. Sci. 2007-08-01;28(8):423-30.

Resonance energy transfer approaches in molecular pharmacology and beyond.Marullo S, Bouvier MTrends Pharmacol. Sci. 2007-08-01;28(8):362-5.

Atypical mitogen-activated protein kinases: structure, regulation and functions.Coulombe P, Meloche SBiochim. Biophys. Acta 2007-08-01;1773(8):1376-87.

The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain.Peng H, Gibson LC, Capili AD, Borden KL, Osborne MJ, Harper SL, Speicher DW, Zhao K, Marmorstein R, Rock TA, Rauscher FJJ. Mol. Biol. 2007-07-06;370(2):269-89.

A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum.Quignodon L, Grijota-Martinez C, Compe E, Guyot R, Allioli N, Laperrière D, Walker R, Meltzer P, Mader S, Samarut J, Flamant FJ. Mol. Endocrinol. 2007-07-01;39(1):17-28.

Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences.Deschênes J, Bourdeau V, White JH, Mader SJ. Biol. Chem. 2007-06-15;282(24):17335-9.

Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET.Héroux M, Breton B, Hogue M, Bouvier MBiochemistry 2007-06-12;46(23):7022-33.

Staufen1 regulates diverse classes of mammalian transcripts.Kim YK, Furic L, Parisien M, Major F, DesGroseillers L, Maquat LEEMBO J. 2007-06-06;26(11):2670-81.

Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, Davison J, Sillaots S, Trosok S, Bachewich C, Bussey H, Youngman P, Roemer TPLoS Pathog. 2007-06-01;3(6):e92.

Poly(I:C) and lipopolysaccharide innate sensing functions of circulating human myeloid dendritic cells are affected in vivo in hepatitis C virus-infected patients.Rodrigue-Gervais IG, Jouan L, Beaulé G, Sauvé D, Bruneau J, Willems B, Sékaly RP, Lamarre DJ. Virol. 2007-06-01;81(11):5537-46.

Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe.Xhemalce B, Miller KM, Driscoll R, Masumoto H, Jackson SP, Kouzarides T, Verreault A, Arcangioli BJ. Biol. Chem. 2007-05-18;282(20):15040-7.

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan FF, Wiseman PW, Bouvier M, Laporte SAJ. Cell. Sci. 2007-05-15;120(Pt 10):1723-32.

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.Meloche S, Pouysségur JOncogene 2007-05-14;26(22):3227-39.

KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.Clapéron A, Therrien MOncogene 2007-05-14;26(22):3143-58.

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis JJ. Biol. Chem. 2007-05-11;282(19):14056-64.

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions.Ohta H, Sekulovic S, Bakovic S, Eaves CJ, Pineault N, Gasparetto M, Smith C, Sauvageau G, Humphries RKExp. Hematol. 2007-05-01;35(5):817-30.

Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.Cellot S, Krosl J, Chagraoui J, Meloche S, Humphries RK, Sauvageau GExp. Hematol. 2007-05-01;35(5):802-16.

Zfx: at the crossroads of survival and self-renewal.Cellot S, Sauvageau GCell 2007-04-20;129(2):239-41.

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.Lupien M, Jeyakumar M, Hébert E, Hilmi K, Cotnoir-White D, Loch C, Auger A, Dayan G, Pinard GA, Wurtz JM, Moras D, Katzenellenbogen J, Mader SMol. Endocrinol. 2007-04-01;21(4):797-816.

c-Jun homodimers can function as a context-specific coactivator.Grondin B, Lefrancois M, Tremblay M, Saint-Denis M, Haman A, Waga K, Bédard A, Tenen DG, Hoang TMol. Cell. Biol. 2007-04-01;27(8):2919-33.

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.Boeglin D, Hamdan FF, Melendez RE, Cluzeau J, Laperriere A, Héroux M, Bouvier M, Lubell WDJ. Med. Chem. 2007-03-22;50(6):1401-8.

When an inhibitor promotes activity.Bouvier MChem. Biol. 2007-03-01;14(3):241-2.

Essential gene identification and drug target prioritization in Aspergillus fumigatus.Hu W, Sillaots S, Lemieux S, Davison J, Kauffman S, Breton A, Linteau A, Xin C, Bowman J, Becker J, Jiang B, Roemer TPLoS Pathog. 2007-03-01;3(3):e24.

[Will academic research rescue the drug discovery crisis?].Bouvier MMed Sci (Paris) 2007-03-01;23(3):227-8.

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding MPharmacol. Rev. 2007-03-01;59(1):5-13.

A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells.Bilodeau M, Girard S, Hébert J, Sauvageau GNat. Methods 2007-03-01;4(3):263-8.

Chromatin challenges during DNA replication and repair.Groth A, Rocha W, Verreault A, Almouzni GCell 2007-02-23;128(4):721-33.

An E2F/miR-20a autoregulatory feedback loop.Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand PJ. Biol. Chem. 2007-01-26;282(4):2135-43.

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.Smith CA, Lau KM, Rahmani Z, Dho SE, Brothers G, She YM, Berry DM, Bonneil E, Thibault P, Schweisguth F, Le Borgne R, McGlade CJEMBO J. 2007-01-24;26(2):468-80.

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.Poyurovsky MV, Priest C, Kentsis A, Borden KL, Pan ZQ, Pavletich N, Prives CEMBO J. 2007-01-10;26(1):90-101.

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola MBMC Bioinformatics 2007-01-01;8:177.

Rational design of an estrogen receptor mutant with altered DNA-binding specificity.Nguyen D, Bail M, Pesant G, Dupont VN, Rouault E, Deschênes J, Rocha W, Melançon G, Steinberg SV, Mader SNucleic Acids Res. 2007-01-01;35(10):3465-77.

Prediction of graft-versus-host disease in humans by donor gene-expression profiling.Baron C, Somogyi R, Greller LD, Rineau V, Wilkinson P, Cho CR, Cameron MJ, Kelvin DJ, Chagnon P, Roy DC, Busque L, Sékaly RP, Perreault CPLoS Med. 2007-01-01;4(1):e23.

Modeling RNA tertiary structure motifs by graph-grammars.St-Onge K, Thibault P, Hamel S, Major FNucleic Acids Res. 2007-01-01;35(5):1726-36.

Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E.Culjkovic B, Topisirovic I, Borden KLCell Cycle 2007-01-01;6(1):65-9.

Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution.Laperriere D, Wang TT, White JH, Mader SBMC Genomics 2007-01-01;8:23.

BRET analysis of GPCR oligomerization: newer does not mean better.Bouvier M, Heveker N, Jockers R, Marullo S, Milligan GNat. Methods 2007-01-01;4(1):3-4; author reply 4.

The V2 vasopressin receptor stimulates ERK1/2 activity independently of heterotrimeric G protein signalling.Charest PG, Oligny-Longpré G, Bonin H, Azzi M, Bouvier MCell. Signal. 2007-01-01;19(1):32-41.

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