Les découvertes réalisées à l’IRIC ont permis des avancées majeures à l’égard de la compréhension du développement du cancer et ouvrent la voie à la mise au point de nouvelles solutions thérapeutiques plus ciblées. Ses publications en sont le reflet. Elles rendent également compte du dynamisme et de la productivité des chercheurs de l’Institut.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis.Sundqvist M, Holdfeldt A, Wright SC, Møller TC, Siaw E, Jennbacken K, Franzyk H, Bouvier M, Dahlgren C, Forsman HBiochim Biophys Acta Mol Cell Res 2020-12-01;1867(12):118849.

The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.Avet C, Sturino C, Grastilleur S, Le Gouill C, Semache M, Gross F, Gendron L, Bennani Y, Mancini JA, Sayegh CE, Bouvier MCommun Biol 2020-11-27;3(1):719.

Proteomics of Herpes Simplex Virus Type 1 Nuclear Capsids.El Bilali N, Khadivjam B, Bonneil E, Thibault P, Lippé RJ Virol 2020-11-25.

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance.Béraud A, Sauvage M, Bazán CM, Tie M, Bencherif A, Bouilly DAnalyst 2020-11-20.

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species.Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EECell Chem Biol 2020-11-19;27(11):1452.

Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.Dodat F, Cotnoir-White D, Dianati E, Vallet A, Mader S, Lévesque DBiochim Biophys Acta Mol Cell Res 2020-11-13;1868(2):118908.

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JNACS Med Chem Lett 2020-11-12;11(11):2261-2267.

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche SOncogene 2020-11-11.

Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.Ghugari R, Tsao S, Schmidt M, Bonneil E, Brenner C, Verreault AFEBS J 2020-11-06.

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.Garrido D, Bourouh M, Bonneil E, Thibault P, Swan A, Archambault VPLoS Genet 2020-11-02;16(11):e1009184.

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carréno SJ Cell Biol 2020-11-02;219(11).

Functional characterization of a PROTAC directed against BRAF mutant V600E.Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri FNat Chem Biol 2020-11-01;16(11):1170-1178.

RAS GTPase signalling to alternative effector pathways.Singh S, Smith MJBiochem Soc Trans 2020-10-30;48(5):2241-2252.

The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.Culjkovic-Kraljacic B, Skrabanek L, Revuelta MV, Gasiorek J, Cowling VH, Cerchietti L, Borden KLBProc Natl Acad Sci U S A 2020-10-27;117(43):26773-26783.

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions.Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, Dolma S, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers MProtein Sci 2020-10-18.

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.Møller TC, Pedersen MF, van Senten JR, Seiersen SD, Mathiesen JM, Bouvier M, Bräuner-Osborne HSci Rep 2020-10-15;10(1):17395.

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith MJSci Signal 2020-10-13;13(653).

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study.Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter CFront Physiol 2020-10-09;11:564140.

Targeting copper metabolism to defeat KRAS-driven colorectal cancer.Aubert L, Nandagopal N, Roux PPMol Cell Oncol 2020-10-07;7(6):1822123.

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age.Grenier-Pleau I, Tyryshkin K, Le TD, Rudan J, Bonneil E, Thibault P, Zeng K, Lässer C, Mallinson D, Lamprou D, Hui J, Postovit LM, Chan EYW, Abraham SAAging Cell 2020-10-07:e13245.

Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.Mast FD, Navare AT, van der Sloot AM, Coulombe-Huntington J, Rout MP, Baliga NS, Kaushansky A, Chait BT, Aderem A, Rice CM, Sali A, Tyers M, Aitchison JDJ. Cell Biol. 2020-10-05;219(10).

UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections.Dumont-Lagacé M, Li Q, Tanguay M, Chagraoui J, Kientega T, Cardin GB, Brasey A, Trofimov A, Carli C, Ahmad I, Bambace NM, Bernard L, Kiss TL, Roy J, Roy DC, Lemieux S, Perreault C, Rodier F, Dufresne SF, Busque L, Lachance S, Sauvageau G, Cohen S, Delisle JSBiol Blood Marrow Transplant 2020-10-03.

ERK signalling: a master regulator of cell behaviour, life and fate.Lavoie H, Gagnon J, Therrien MNat Rev Mol Cell Biol 2020-10-01;21(10):607-632.

Major multilevel molecular divergence between THP-1 cells from different biorepositories.Noronha N, Ehx G, Meunier MC, Laverdure JP, Thériault C, Perreault CInt. J. Cancer 2020-10-01;147(7):2000-2006.

Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only.LeBlanc R, Claveau JS, Ahmad I, Delisle JS, Bambace N, Bernard L, Cohen S, Kiss T, Lachance S, Landais S, Roy DC, Sauvageau G, Roy JClin Transplant 2020-09-27:e14099.

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone.Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CC, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil E, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, Karamchandani J, Dickson BC, Turcotte R, Wunder JS, Thibault P, Lewis PW, Garcia BA, Mack SC, Taylor MD, Garzia L, Kleinman CL, Jabado NCancer Discov 2020-09-23.

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros PCell Rep 2020-09-22;32(12):108170.

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.Sun C, Wang K, Stock AJ, Gong Y, Demarest TG, Yang B, Giri N, Harrington L, Alter BP, Savage SA, Bohr VA, Liu YEMBO J 2020-09-16:e103420.

The Origin and Immune Recognition of Tumor-Specific Antigens.Apavaloaei A, Hardy MP, Thibault P, Perreault CCancers (Basel) 2020-09-12;12(9).

G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase.Black L, Tollis S, Fu G, Fiche JB, Dorsey S, Cheng J, Ghazal G, Notley S, Crevier B, Bigness J, Nollmann M, Tyers M, Royer CAJ. Cell Biol. 2020-09-07;219(9).

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sánchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington LMol Cell 2020-09-03;79(5):846-856.e8.

Agonist-induced formation of unproductive receptor-G12 complexes.Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NAProc Natl Acad Sci U S A 2020-09-01;117(35):21723-21730.

IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells.Benhammadi M, Mathé J, Dumont-Lagacé M, Kobayashi KS, Gaboury L, Brochu S, Perreault CJ. Immunol. 2020-09-01;205(5):1268-1280.

Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.Deblois G, Tonekaboni SAM, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien MCancer Discov 2020-09-01;10(9):1312-1329.

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer.Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, Haight J, Tonekaboni SAM, Fortier AM, Kuasne H, McKee TD, Mahmoud H, Kushida M, Cameron S, Dogan-Artun N, Chen W, Nie Y, Zhang LX, Vellanki RN, Zhou S, Prinos P, Wouters BG, Dirks PB, Done SJ, Park M, Cescon DW, Haibe-Kains B, Lupien M, Arrowsmith CHNat Commun 2020-08-21;11(1):4205.

An ErbB2 splice variant lacking exon 16 drives lung carcinoma.Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJProc. Natl. Acad. Sci. U.S.A. 2020-08-18;117(33):20139-20148.

Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors.Claveau JS, Cohen S, Ahmad I, Delisle JS, Kiss T, Lachance S, Sauvageau G, Busque L, Brito RM, Bambace N, Bernard L, Roy DC, Roy JEur J Haematol 2020-08-04.

RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.Miao Z, Adamiak RW, Antczak M, Boniecki MJ, Bujnicki J, Chen SJ, Cheng CY, Cheng Y, Chou FC, Das R, Dokholyan NV, Ding F, Geniesse C, Jiang Y, Joshi A, Krokhotin A, Magnus M, Mailhot O, Major F, Mann TH, Piątkowski P, Pluta R, Popenda M, Sarzynska J, Sun L, Szachniuk M, Tian S, Wang J, Wang J, Watkins AM, Wiedemann J, Xiao Y, Xu X, Yesselman JD, Zhang D, Zhang Y, Zhang Z, Zhao C, Zhao P, Zhou Y, Zok T, Żyła A, Ren A, Batey RT, Golden BL, Huang L, Lilley DM, Liu Y, Patel DJ, Westhof ERNA 2020-08-01;26(8):982-995.

BMP signaling is essential for sustaining proximo-distal progression in regenerating axolotl limbs.Vincent E, Villiard E, Sader F, Dhakal S, Kwok BH, Roy SDevelopment 2020-07-31;147(14).

Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-κB signaling pathway.Migneault F, Dieudé M, Turgeon J, Beillevaire D, Hardy MP, Brodeur A, Thibodeau N, Perreault C, Hébert MJSci Rep 2020-07-28;10(1):12562.

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PPNat Commun 2020-07-24;11(1):3701.

Genetically encoded intrabody sensors report the interaction and trafficking of β-arrestin 1 upon activation of G-protein-coupled receptors.Baidya M, Kumari P, Dwivedi-Agnihotri H, Pandey S, Sokrat B, Sposini S, Chaturvedi M, Srivastava A, Roy D, Hanyaloglu AC, Bouvier M, Shukla AKJ. Biol. Chem. 2020-07-24;295(30):10153-10167.

Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells.Ghanbari F, Mader S, Philip ACells 2020-07-23;9(8).

Survey Says: "COVID-19 Lockdown Hits Young Faculty and Clinical Trials".Kent DG, Knapp DJHF, Kannan NStem Cell Reports 2020-07-14;15(1):1-5.

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith MJ, Côté JF, Barford DNat Commun 2020-07-10;11(1):3464.

Extending the Comprehensiveness of Immunopeptidome Analyses Using Isobaric Peptide Labeling.Pfammatter S, Bonneil E, Lanoix J, Vincent K, Hardy MP, Courcelles M, Perreault C, Thibault PAnal. Chem. 2020-07-07;92(13):9194-9204.

Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors.Wang X, Wang H, Liu L, Li S, Emery G, Chen JiScience 2020-07-01;23(7):101335.

Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition.Trofimov A, Cohen JP, Bengio Y, Perreault C, Lemieux SBioinformatics 2020-07-01;36(Supplement_1):i417-i426.

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras GNat. Cell Biol. 2020-07-01;22(7):803-814.

MYC-induced human acute myeloid leukemia requires a continuing IL3/GM-CSF co-stimulus.Bulaeva E, Pellacani D, Nakamichi N, Hammond CA, Beer P, Lorzadeh A, Moksa M, Carles A, Bilenky M, Lefort S, Shu JY, Wilhelm B, Weng A, Hirst M, Eaves CJBlood 2020-06-29.

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice.Grants JM, Wegrzyn J, Hui T, O'Neill K, Shadbolt M, Knapp DJHF, Parker J, Deng Y, Gopal A, Docking TR, Fuller M, Li J, Boldin M, Eaves CJ, Hirst M, Karsan ABlood 2020-06-18;135(25):2235-2251.

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MDCell 2020-06-11;181(6):1329-1345.e24.

The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery.Borden KLB, Volpon LRNA Biol 2020-06-04:1-13.

From transient recognition to efficient silencing: a RISCky business.Major FNat. Struct. Mol. Biol. 2020-06-01;27(6):519-520.

Signal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR.Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin RD, Longpré JM, Amraei M, Shinjo Y, Hogue M, Lagacé M, Breton B, Aoki J, Tanny JC, Laporte SA, Pineyro G, Inoue A, Bouvier M, Hébert TESci Rep 2020-05-29;10(1):8779.

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PPCell Rep 2020-05-19;31(7):107660.

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu YAm. J. Respir. Crit. Care Med. 2020-05-15;201(10):1263-1276.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy DNat Commun 2020-05-14;11(1):2396.

Interferon, restriction factors and SUMO pathways.El-Asmi F, McManus FP, Thibault P, Chelbi-Alix MKCytokine Growth Factor Rev. 2020-05-08.

A targetable cue in T-cell malignancy.Gerby B, Hoang TBlood 2020-05-07;135(19):1616-1617.

Interplay of Ubiquitin-Like Modifiers Following Arsenic Trioxide Treatment.Rinfret Robert C, McManus FP, Lamoliatte F, Thibault PJ. Proteome Res. 2020-05-01;19(5):1999-2010.

Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.Larouche JD, Trofimov A, Hesnard L, Ehx G, Zhao Q, Vincent K, Durette C, Gendron P, Laverdure JP, Bonneil E, Côté C, Lemieux S, Thibault P, Perreault CGenome Med 2020-04-28;12(1):40.

Controversies around the function of LARP1.Berman AJ, Thoreen CC, Dedeic Z, Chettle J, Roux PP, Blagden SPRNA Biol 2020-04-17:1-11.

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington LElife 2020-04-16;9.

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers MGenetics 2020-04-15;214(4):1103-1120.

The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML.Lin H, Rothe K, Chen M, Wu A, Babaian A, Yen R, Zeng J, Ruschmann J, Petriv OI, O'Neill K, Maetzig T, Knapp DJHF, Nakamichi N, Brinkman R, Birol I, Forrest DL, Hansen C, Humphries KK, Eaves CJ, Jiang XBlood 2020-04-09.

Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin.Picard LP, Schonegge AM, Bouvier MACS Pharmacol Transl Sci 2020-04-09;2(3):148-154.

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TALeukemia 2020-04-03.

MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses.Courcelles M, Durette C, Daouda T, Laverdure JP, Vincent K, Lemieux S, Perreault C, Thibault PJ. Proteome Res. 2020-04-03;19(4):1873-1881.

Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer.Zhao Q, Laverdure JP, Lanoix J, Durette C, Côté C, Bonneil E, Laumont CM, Gendron P, Vincent K, Courcelles M, Lemieux S, Millar DG, Ohashi PS, Thibault P, Perreault CCancer Immunol Res 2020-04-03;8(4):544-555.

Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly JHum. Mol. Genet. 2020-03-31;29(5):766-784.

Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts.Dieudé M, Turgeon J, Karakeussian Rimbaud A, Beillevaire D, Qi S, Patey N, Gaboury LA, Boilard E, Hébert MJAm. J. Transplant. 2020-03-20;20(3):726-738.

Cross-talk between SUMOylation and ISGylation in response to interferon.El-Asmi F, McManus FP, Brantis-de-Carvalho CE, Valle-Casuso JC, Thibault P, Chelbi-Alix MKCytokine 2020-02-17;129:155025.

Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility.Li C, McManus FP, Plutoni C, Pascariu CM, Nelson T, Alberici Delsin LE, Emery G, Thibault PNat Commun 2020-02-14;11(1):834.

High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients.Simon L, Spinella JF, Yao CY, Lavallée VP, Boivin I, Boucher G, Audemard E, Bordeleau ME, Lemieux S, Hebert J, Sauvageau GBlood 2020-02-13.

Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.Dumont-Lagacé M, Daouda T, Depoërs L, Zumer J, Benslimane Y, Brochu S, Harrington L, Lemieux S, Perreault CFront Immunol 2020-02-11;10:3118.

Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen HCell Mol Life Sci 2020-02-10.

Editorial overview: The instability of the cancer genome: it starts at the end.Harrington L, Baird DMCurr. Opin. Genet. Dev. 2020-02-01;60:iii-vi.

Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau GLancet Haematol 2020-01-31;7(2):e134-e145.

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EKDev. Cell 2020-01-29;52(2):210-222.e7.

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok BH, Peng AElife 2020-01-21;9.

The Genomic Landscape of Antigenic Targets for T Cell-Based Leukemia Immunotherapy.Hardy MP, Vincent K, Perreault CFront Immunol 2020-01-13;10:2934.

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment.García RA, Ito BR, Lupisella JA, Carson NA, Hsu MY, Fernando G, Heroux M, Bouvier M, Dierks E, Kick EK, Gordon DA, Chen J, Mintier G, Carrier M, St-Onge S, Shah H, Towne J, Bucardo MS, Ma X, Ryan CS, Wurtz NR, Ostrowski J, Villarreal FJJACC Basic Transl Sci 2020-01-09;4(8):905-920.

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PPMol. Cell Proteomics 2020-01-02;19(1):50-64.

A transcriptome-based approach to identify functional modules within and across primary human immune cells.Mola S, Foisy S, Boucher G, Major F, Beauchamp C, Karaky M, Goyette P, Lesage S, Rioux JDPLoS ONE 2020-01-01;15(5):e0233543.

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