Publications

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit RMol. Cell. Biol. 2017-12-15;37(24).

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TDBioconjug. Chem. 2017-06-21;28(6):1677-1683.

Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.Mathien S, Déléris P, Soulez M, Voisin L, Meloche SMol. Cell. Biol. 2017-05-01;37(9).

Isolation of Mouse Embryonic Stem Cell Lines in the Study of ERK1/2 MAP Kinase Signaling.Saba-El-Leil MK, Frémin C, Meloche SMethods Mol. Biol. 2017-01-01;1487:243-253.

ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche SOncogene 2016-10-27;35(43):5692-5698.

Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress.Pew BK, Harris RA, Sbrana E, Guaman MC, Shope C, Chen R, Meloche S, Aagaard KAm. J. Obstet. Gynecol. 2016-09-01;215(3):384.e1-384.e89.

Redundancy in the World of MAP Kinases: All for One.Saba-El-Leil MK, Frémin C, Meloche SFront Cell Dev Biol 2016-06-27;4:67.

Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche SCell Cycle 2016-06-17;15(12):1631-42.

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau GBlood 2016-06-16;127(24):3054-61.

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau GNat. Genet. 2015-09-01;47(9):1030-7.

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