Publications

Signaling by the tyrosine kinase Yes promotes liver cancer development.Guégan JP, Lapouge M, Voisin L, Saba-El-Leil MK, Tanguay PL, Lévesque K, Brégeon J, Mes-Masson AM, Lamarre D, Haibe-Kains B, Trinh VQ, Soucy G, Bilodeau M, Meloche SSci Signal 2022-01-18;15(717):eabj4743.

Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential.Mathien S, Tesnière C, Meloche SPharmacol Rev 2021-10-01;73(4):263-296.

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer.Girondel C, Meloche SFront Oncol 2021-03-23;11:656004.

Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.Girondel C, Lévesque K, Langlois MJ, Pasquin S, Saba-El-Leil MK, Rivard N, Friesel R, Servant MJ, Gauchat JF, Lesage S, Meloche SOncogene 2021-01-01;40(2):452-464.

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PPNat Commun 2020-07-24;11(1):3701.

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.Soulez M, Saba-El-Leil MK, Turgeon B, Mathien S, Coulombe P, Klinger S, Rousseau J, Lévesque K, Meloche SMol. Cell. Biol. 2019-03-15;39(6).

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.Fink S, Zugelder L, Roth B, Brandt E, Meloche S, Izsvák Z, Bargou RC, Stühmer TPLoS ONE 2018-10-19;13(10):e0205585.

Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration.Pyakurel A, Balmer D, Saba-El-Leil MK, Kizilyaprak C, Daraspe J, Humbel BM, Voisin L, Le YZ, von Lintig J, Meloche S, Roduit RMol. Cell. Biol. 2017-12-15;37(24).

Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TDBioconjug. Chem. 2017-06-21;28(6):1677-1683.

Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity.Mathien S, Déléris P, Soulez M, Voisin L, Meloche SMol. Cell. Biol. 2017-05-01;37(9).

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