The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.Mol Biol Cell 2022-05-01;33(5):rp2.
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.ACS Chem Biol 2022-03-18;17(3):680-700.
The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.PLoS Biol 2022-03-01;20(3):e3001548.
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.Blood Adv 2022-01-25;6(2):509-514.
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.Sci Adv 2021-10-29;7(44):eabi5797.
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol 2021-10-16;433(23):167294.
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.NAR Cancer 2021-06-01;3(2):zcab019.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.Aging Cell 2021-03-04:e13331.
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.Nat Commun 2021-02-12;12(1):979.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell 2021-01-07;28(1):48-62.e6.