Publications

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Baril C, Gavory G, Bidla G, Knævelsrud H, Sauvageau G, Therrien MDev. Biol. 2017-01-01;421(1):16-26.

Inhibition of RAS function through targeting an allosteric regulatory site.Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JPNat. Chem. Biol. 2017-01-01;13(1):62-68.

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien MPLoS Biol. 2016-08-01;14(8):e1002539.

Regulation of RAF protein kinases in ERK signalling.Lavoie H, Therrien MNat. Rev. Mol. Cell Biol. 2015-04-23;16(5):281-98.

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien MNat. Struct. Mol. Biol. 2015-01-01;22(1):37-43.

Dimerization-induced allostery in protein kinase regulation.Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri FTrends Biochem. Sci. 2014-10-01;39(10):475-486.

Apical Accumulation of the Sevenless Receptor Tyrosine Kinase During Drosophila Eye Development Is Promoted by the Small GTPase Rap1.Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien MGenetics 2014-06-03;197(4):1237-1250.

Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el BMol. Cell 2014-05-08;54(3):392-406.

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila.Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien MPLoS Biol. 2014-03-01;12(3):e1001809.

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien MNat. Chem. Biol. 2013-07-01;9(7):428-36.

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