Publications

ERK signalling: a master regulator of cell behaviour, life and fate.Lavoie H, Gagnon J, Therrien MNat. Rev. Mol. Cell Biol. 2020-06-23.

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EBNat Commun 2018-10-22;9(1):4385.

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick FAm. J. Med. Genet. A 2018-10-10:e40632.

MEK drives BRAF activation through allosteric control of KSR proteins.Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien MNature 2018-02-22;554(7693):549-553.

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien MNat Commun 2017-10-31;8(1):1211.

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.Kubiniok P, Lavoie H, Therrien M, Thibault PMol. Cell Proteomics 2017-04-01;16(4):663-679.

How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Ashton-Beaucage D, Therrien MMethods Mol. Biol. 2017-01-01;1487:1-21.

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Baril C, Gavory G, Bidla G, Knævelsrud H, Sauvageau G, Therrien MDev. Biol. 2017-01-01;421(1):16-26.

Inhibition of RAS function through targeting an allosteric regulatory site.Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JPNat. Chem. Biol. 2017-01-01;13(1):62-68.

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien MPLoS Biol. 2016-08-01;14(8):e1002539.

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