Publications

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.Gavory G, Baril C, Laberge G, Bidla G, Koonpaew S, Sonea T, Sauvageau G, Therrien MPLoS Genet 2021-08-12;17(8):e1009730.

Functional characterization of a PROTAC directed against BRAF mutant V600E.Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri FNat Chem Biol 2020-11-01;16(11):1170-1178.

ERK signalling: a master regulator of cell behaviour, life and fate.Lavoie H, Gagnon J, Therrien MNat Rev Mol Cell Biol 2020-10-01;21(10):607-632.

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EBNat Commun 2018-10-22;9(1):4385.

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick FAm. J. Med. Genet. A 2018-10-10:e40632.

MEK drives BRAF activation through allosteric control of KSR proteins.Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien MNature 2018-02-22;554(7693):549-553.

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien MNat Commun 2017-10-31;8(1):1211.

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.Kubiniok P, Lavoie H, Therrien M, Thibault PMol. Cell Proteomics 2017-04-01;16(4):663-679.

How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Ashton-Beaucage D, Therrien MMethods Mol. Biol. 2017-01-01;1487:1-21.

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila.Baril C, Gavory G, Bidla G, Knævelsrud H, Sauvageau G, Therrien MDev. Biol. 2017-01-01;421(1):16-26.

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