Course coordinator : Martine Raymond
Terms: Fall, Winter
Number of credits : 1

During the BIM6035 course, students present the two research projects they have undertaken during their laboratory rotations (BIM6076A and BIM6076B). Lasting 20 minutes, this seminar is organized as follows: an introduction to the topic of research including a review of literature, a description of the research projects objectives, a presentation of the results, a discussion and conclusion on the results and a description of upcoming experiments. This course aims to teach students how to summarize their research, to present scientific results orally and to discuss their research project.

Course coordinators : Gregory Emery, Sylvie Mader
Term: Summer
Number of credits : 2

The BIM6064A course offers lectures in the fields of cellular and molecular biology of cancer, addressing in particular the mechanisms of gene expression and cell cycle control, their regulation by signalling pathways and deregulation in cancer. This course includes the following presentations:

• Transcriptional regulation of gene expression and cancer (by Sylvie Mader)
• Epigenetic regulation of gene expression and cancer (by Julie Lessard)
• Regulation of gene expression at the post-transcriptional level (by Katherine Borden)
• DNA replication and chromosomal integrity (by Lea Harrington)
• Biology of miRNAs (by Gerardo Ferbeyre)
• Biophysical analysis of the structure of macromolecules (by Katherine Borden)
• Signalling pathways (by Gregory Emery)
• Signalling and cell cycle progression (by Sylvain Meloche)
• Molecular genetics of cancer (by Trang Hoang)

Course coordinators: Sébastien Carréno, Philippe Roux, Sylvie Mader
Term: Summer
Number of credits : 2

The BIM6064C course offers lectures on state-of-the-art systems biology approaches for the analysis of cell signalling and molecular genetics and their contribution to research in cancer biology and molecular genetics. This course includes the following presentations:

• How to write a scholarship application (by Sylvie Mader)
• RNAi screens in Drosophila melanogaster (by Sébastien Carréno)
• Proteomics (by Pierre Thibault)
• The phosphoproteome (by Philippe Roux)
• Genetic screens (by Vincent Archambault)
• Network modeling and analysis (by Stephen Michnick)
• Synthetic biology (by Mike Tyers)

Course coordinators: Lea Harrington, Michael Tyers, Sylvie Mader
Term: Summer
Number of credits : 2

This course emphasizes hands-on training in molecular biology (e.g. site-directed mutagenesis, DNA sequencing and construction of expression vectors by conventional molecular cloning and by in vitro recombination). It familiarizes students with simple, rapid and efficient recombinant DNA techniques, This course includes bench work and use of equipment at IRIC genomics core facility, formal presentations, group discussions and written assignments.

Course coordinator: François Major, Sébastien Lemieux, Sylvie Mader
Term: Summer
Number of credits : 1

Through lectures and computer lab sessions, this course aims at familiarizing students with 1) databases, 2) network analysis, and 3) modeling of the structure of macromolecule. It includes formal presentations and leading to a variety of assignments.

Course coordinators: Benjamin Kwok, Sylvie Mader
Term: Summer
Number of credits : 1

This course offers laboratory training in protein biochemistry techniques and follows the BIM6065A course. It familiarizes students with techniques to 1) express and purify proteins (e.g. FPLC chromatography), and 2) study the chemical and biophysical properties of proteins (e.g. mass spectrometry, circular dichroism and ultracentrifugation). This course includes laboratory training, experiments making use of IRIC proteomics and biophysics core facilities, formal presentations, group discussions and written assignments.

Nombre de crédits: 1

Description

Les développements biomédicaux et l’éthique de la recherche; les grands textes régulateurs; le rapport éthique et technoscience; l’évaluation éthique d’un projet; l’intégrité scientifique du chercheur.

Course coordinators: Jean-Claude Labbé, Sylvie Mader
Term: Summer
Number of credits : 2

The BIM6064B course offers lectures on the molecular genetics of eukaryotes and the use of biological models for the study of cell signalling and cancer. It aims at highlighting the impact of genetic research using biological models on our understanding of cancer. This course includes the following presentations:

• Thinking like a geneticist  (by Alain Verreault)
• Caenorhabditis elegans: signalling in multicellular organisms (by Jean-Claude Labbé)
• Xenopus laevis as a model organism (by Benjamin Kwok)
• The mouse: analyzing the function of genes in mammals (by Benjamin Turgeon)
• Drosophila melanogaster: genetics of higher eukaryotes (by Marc Therrien)
• Eukaryotic cells in culture: genetics of cancer (by Guy Sauvageau)
• Yeasts: genetics of unicellular eukaryotes (by Martine Raymond)
• Fundamentals in light and fluorescence microscopy  (by Étienne Gagnon)

Course coordinator: Claude Perreault, Sylvie Mader
Term: Summer
Number of credits : 2

The BIM6064D course offers lectures on therapeutic targeting, drug development, translational and clinical research in leukemia and breast cancer, the use of stem cells in cancer therapy, and immunotherapy. It reviews basic concepts in immunology and oncology and presents examples of drug development and translational cancer research. In addition to the visit of IRIC histology and high-throughput screening core facilities, this course includes the following lectures:

• Malignant hemopathies (by Jean Roy)
• Chromosomal aberrations / Laboratory tests in clinical hematology and cancer (by Josée Hébert)
• Stem cells and cancer treatment (by Guy Sauvageau)
• How to set up clinical trials in cell therapy (by Denis-Claude Roy)
• Drug development and high-throughput screening (by Benjamin Kwok)
• Pharmacological modulation of cell signalling: membrane receptors (by Michel Bouvier)
• Pharmacological modulation of cell signalling: nuclear receptors and cancer (by Sylvie Mader)
• Breast cancer, clinical tests and histology (by Louis Gaboury)
• General concepts of immunology and antigen presentation (by Claude Perreault)
• Function of T-cell and cancer immunotherapy (by Etienne Gagnon)
• Innate immunity (by John White)
• Testimony from a cancer survivor (speaker to be announced)

Course coordinator: Trang Hoang, Sylvie Mader
Term: Summer
Number of credits : 1

This course offers laboratory training on cell analysis by microscopy and flow cytometry using various models (e.g. transgenic mice, Caenorhabditis elegans, Drosophila melanogaster). It aims at familiarizing students with techniques for 1) dissection and cell analysis using model organisms, 2) mouse transgenesis, 3) flow cytometry and data analysis, and 4) confocal microscopy. This course includes visits and/or use of several IRIC core facilities (i.e. Flow cytometry, Bioimaging, Transgenesis), lectures (e.g. on bioimaging tools) and demonstrations leading to various assignments.

Course coordinator: Brian Wilhelm, Sébastien Lemieux
Term: Summer
Number of credits : 1

This module offers training in functional genomics, with a focus on the analysis of genomes and gene expression patterns by DNA microarray analysis and high-throughput sequencing. It provides hands-on training in large scale chromatin immunoprecipitation, DNA microarray hybridization and data analysis. This module includes lectures and laboratory training leading to various assignments.

Course coordinator: Sébastien Carréno
Terms: Fall, Winter
Number of credits : 16

The BIM6077A and BIM6077B courses correspond to laboratory rotations taking place in two separate research teams. During these rotations, lasting four months each, you will be working on research projects under the supervision of a principal investigator. At the end of each rotation, you will be writing an internship report in the form of a scientific manuscript.

Course coordinator: Sébastien Carréno
Terms: Fall, Winter
Number of credits : 16

The BIM6077A and BIM6077B courses correspond to laboratory rotations taking place in two separate research teams. During these rotations, lasting four months each, you will be working on research projects under the supervision of a principal investigator. At the end of each rotation, you will be writing an internship report in the form of a scientific manuscript.