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Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?

Sauvageau G, Perreault C

Laboratory of Molecular Genetics of Stem Cells, Institute for Research in Immunology and Cancer (IRIC), C.P. 6128 succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.

c-myc is a key regulator of hemopoietic stem cell (HSC) activity. In this issue of Cell Stem Cell, Laurenti et al. (2008) show that c-myc and N-myc control HSC survival and link this finding to the regulation of granzyme B expression.

Cell Stem Cell 2008;3(6):579-80.

Pubmed ID: 19041771

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