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Histone post-translational modifications and the response to DNA double-strand breaks.

Wurtele H, Verreault A

Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Pavillon Marcelle-Coutu, 2950 Chemin Polytechnique, Montreal H3T 1J4, Canada.

The packaging of DNA into chromatin creates a number of significant barriers to the detection of DNA lesions and their timely and accurate repair. Eukaryotic cells have evolved a number of enzymes that modulate chromatin structure and facilitate DNA repair. Recent research illustrates how nucleosome remodelling enzymes cooperate with both DNA-damage-inducible and constitutive histone modifications to promote many facets of the cellular response to DNA damage.

Curr. Opin. Cell Biol. 2006;18(2):137-44.

Pubmed ID: 16487697

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