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At Long Last, a C-Terminal Bookend for the Ubiquitin Code.

Chatr-Aryamontri A, van der Sloot A, Tyers M

Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada.

The ubiquitin-proteasome system controls the stability of myriad protein substrates via short sequence motifs called degrons. Studies by Koren et al. (2018) and Lin et al. (2018) have uncovered a broad new class of degrons located at the extreme C terminus of substrates.

Mol. Cell 2018;70(4):568-571.

Pubmed ID: 29775575

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