At Long Last, a C-Terminal Bookend for the Ubiquitin Code.
Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC H3C 3J7, Canada.
The ubiquitin-proteasome system controls the stability of myriad protein substrates via short sequence motifs called degrons. Studies by Koren et al. (2018) and Lin et al. (2018) have uncovered a broad new class of degrons located at the extreme C terminus of substrates.
Mol. Cell 2018;70(4):568-571.
Pubmed ID: 29775575