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Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

Williams V, Grosset AA, Zamorano Cuervo N, St-Pierre Y, Sylvestre MP, Gaboury L, Grandvaux N

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, 900 rue Saint-Denis, Montréal, Qc H2X 0A9, Canada.

IKKε is an oncogenic kinase that was found amplified and overexpressed in a substantial percentage of human breast cancer cell lines and primary tumors using genomic and gene expression analyses. Molecular studies have provided the rational for a key implication of IKKε in breast cancer cells proliferation and invasiveness through the phosphorylation of several substrates.

BMC Cancer 2017;17(1):356.

Pubmed ID: 28532474

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