Kit and Scl regulation of hematopoietic stem cells.
aInstitute of Research in Immunology and Cancer, University of Montreal bMolecular Biology Program, Faculty of Medicine, University of Montreal cInstitut de Recherches Cliniques de Montreal (IRCM) dDepartment of Biochemistry eDepartment of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
KIT tyrosine kinase receptor is essential for several tissue stem cells, especially for hematopoietic stem cells (HSCs). Moderately decreased KIT signaling is well known to cause anemia and defective HSC self-renewal, whereas gain-of-function mutations are infrequently found in leukemias. Thus, maintaining KIT signal strength is critically important for homeostasis. KIT signaling in HSCs involves effectors such as SHP2 and PTPN11. This review summarizes the recent developments on the novel mechanisms regulating or reinforcing KIT signal strength in HSCs and its perturbation in polycythemia vera.
Curr. Opin. Hematol. 2014;21(4):256-264.
Pubmed ID: 24857885