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Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.

Yoon SO, Roux PP

Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.

Curr. Biol. 2013;23(19):R880-3.

Pubmed ID: 24112984

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