Liver fibrosis protects mice from acute hepatocellular injury.
Laboratoire d'Hépatologie Cellulaire du Centre de Recherche du CHUM-Hôpital Saint-Luc, Montréal, Québec, Canada.
Development of fibrosis is part of the pathophysiologic process of chronic liver disease. Although it is considered deleterious, it also represents a form of tissue repair. Deposition of extracellular matrix changes the cellular environment of the liver; we investigated whether it increases resistance to noxious stimuli and the role of changes in intracellular signaling to hepatocytes in mediating this effect.
Pubmed ID: 21945831