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Liver fibrosis protects mice from acute hepatocellular injury.

Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M

Laboratoire d'Hépatologie Cellulaire du Centre de Recherche du CHUM-Hôpital Saint-Luc, Montréal, Québec, Canada.

Development of fibrosis is part of the pathophysiologic process of chronic liver disease. Although it is considered deleterious, it also represents a form of tissue repair. Deposition of extracellular matrix changes the cellular environment of the liver; we investigated whether it increases resistance to noxious stimuli and the role of changes in intracellular signaling to hepatocytes in mediating this effect.

Gastroenterology 2012;142(1):130-139.e4.

Pubmed ID: 21945831

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