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Building a new conceptual framework for receptor heteromers.

Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, Waldhoer M, Woods AS, Franco R

National Institute on Drug Abuse, IRP, NIH, DHHS, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA. sferre@intra.nida.nih.gov

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

Nat. Chem. Biol. 2009;5(3):131-4.

Pubmed ID: 19219011

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