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Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.

Heinonen KM, Vanegas JR, Lew D, Krosl J, Perreault C

Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, Quebec, Canada.

While the role of canonical (β-catenin-mediated) Wnt signaling in hematolymphopoiesis has been studied extensively, little is known of the potential importance of non-canonical Wnt signals in hematopoietic cells. Wnt4 is one of the Wnt proteins that can elicit non-canonical pathways. We have previously shown that retroviral overexpression of Wnt4 by hematopoietic cells increased thymic cellularity as well as the frequency of early thymic progenitors and bone marrow hematopoietic progenitor cells (HPCs). However, the molecular pathways responsible for its effect in HPCs are not known.

PLoS ONE 2011;6(4):e19279.

Pubmed ID: 21541287

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